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公开(公告)号：US20140056961A1
公开(公告)日：2014-02-27
申请号：US14051544
申请日：2013-10-11
Applicant: Karl Malcolm , David Woolfson , Joseph Romano
Inventor： Karl Malcolm , David Woolfson , Joseph Romano
IPC: A61K9/00 , A61K31/505
CPC classification number: A61K9/0036 , A61K31/444 , A61K31/505
Abstract: The present invention provides improved intravaginal drug delivery devices, i.e., intravaginal rings, useful for the prophylactic administration of an antimicrobial compound, e.g., Dapivirine, to a human. The intravaginal rings of the invention address previous stability issues by utilizing a platinum catalyst (e.g., in the form of a platinum-siloxane complex) for the cross-linking reaction. The vaginal rings surprisingly achieve relatively high and steady release rates in vivo with a matrix ring containing a relatively small loading dose. While the matrix rings of the present invention have in vivo the steady release rates associated with reservoir rings, they are easier and less expensive to manufacture. The present invention also provides methods of blocking DNA polymerization by an HIV reverse transcriptase enzyme, methods of preventing HIV infection in a female human, methods of treating HIV infection in a female human, and methods of preparing platinum-catalyzed intravaginal rings.
Abstract translation: 本发明提供改进的阴道内药物递送装置，即阴道内环，其可用于向人类预防性施用抗微生物化合物例如达匹维林。 本发明的阴道内环通过利用铂催化剂（例如铂 - 硅氧烷复合物的形式）来解决先前的稳定性问题，用于交联反应。 使用含有相对小的负荷剂量的基质环，阴道环令人惊讶地在体内达到相对高且稳定的释放速率。 尽管本发明的基质环体内具有与储库环相关联的稳定释放速率，但它们制造更容易且成本更低。 本发明还提供了通过HIV逆转录酶阻断DNA聚合的方法，在女性人体中预防HIV感染的方法，在女性人体中治疗HIV感染的方法，以及制备铂催化的阴道内环的方法。
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公开(公告)号：US20070004694A1
公开(公告)日：2007-01-04
申请号：US11454697
申请日：2006-06-16
Applicant: David Woolfson , Karl Malcolm
Inventor： David Woolfson , Karl Malcolm
CPC classification number: A61K31/565 , A61K9/0034 , A61K31/56 , A61K47/10 , A61K47/32
Abstract: Pharmaceutical gel compositions containing estrogen for vaginal administration, as well as a method of making the same, are disclosed.
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公开(公告)号：US08580294B2
公开(公告)日：2013-11-12
申请号：US13276454
申请日：2011-10-19
Applicant: Karl Malcolm , David Woolfson , Joseph Romano
Inventor： Karl Malcolm , David Woolfson , Joseph Romano
CPC classification number: A61K9/0036 , A61K31/444 , A61K31/505
Abstract: The present invention provides improved intravaginal drug delivery devices, i.e., intravaginal rings, useful for the prophylactic administration of an antimicrobial compound, e.g., Dapivirine, to a human. The intravaginal rings of the invention address previous stability issues by utilizing a platinum catalyst (e.g., in the form of a platinum-siloxane complex) for the cross-linking reaction. The vaginal rings surprisingly achieve relatively high and steady release rates in vivo with a matrix ring containing a relatively small loading dose. While the matrix rings of the present invention have in vivo the steady release rates associated with reservoir rings, they are easier and less expensive to manufacture. The present invention also provides methods of blocking DNA polymerization by an HIV reverse transcriptase enzyme, methods of preventing HIV infection in a female human, methods of treating HIV infection in a female human, and methods of preparing platinum-catalyzed intravaginal rings.
Abstract translation: 本发明提供改进的阴道内药物递送装置，即阴道内环，其可用于向人类预防性施用抗微生物化合物例如达匹维林。 本发明的阴道内环通过利用铂催化剂（例如铂 - 硅氧烷复合物的形式）来解决先前的稳定性问题，用于交联反应。 使用含有相对小的负荷剂量的基质环，阴道环令人惊讶地在体内达到相对高且稳定的释放速率。 尽管本发明的基质环体内具有与储库环相关联的稳定释放速率，但它们制造更容易且成本更低。 本发明还提供了通过HIV逆转录酶阻断DNA聚合的方法，在女性人体中预防HIV感染的方法，在女性人体中治疗HIV感染的方法，以及制备铂催化的阴道内环的方法。
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公开(公告)号：US20120093911A1
公开(公告)日：2012-04-19
申请号：US13276454
申请日：2011-10-19
Applicant: Karl Malcolm , David Woolfson , Joseph Romano
Inventor： Karl Malcolm , David Woolfson , Joseph Romano
IPC: A61K31/444 , A61P31/00 , A61P31/18 , A61K9/00
CPC classification number: A61K9/0036 , A61K31/444 , A61K31/505
Abstract: The present invention provides improved intravaginal drug delivery devices, i.e., intravaginal rings, useful for the prophylactic administration of an antimicrobial compound, e.g., Dapivirine, to a human. The intravaginal rings of the invention address previous stability issues by utilizing a platinum catalyst (e.g., in the form of a platinum-siloxane complex) for the cross-linking reaction. The vaginal rings surprisingly achieve relatively high and steady release rates in vivo with a matrix ring containing a relatively small loading dose. While the matrix rings of the present invention have in vivo the steady release rates associated with reservoir rings, they are easier and less expensive to manufacture. The present invention also provides methods of blocking DNA polymerization by an HIV reverse transcriptase enzyme, methods of preventing HIV infection in a female human, methods of treating HIV infection in a female human, and methods of preparing platinum-catalyzed intravaginal rings.
Abstract translation: 本发明提供改进的阴道内药物递送装置，即阴道内环，其可用于向人类预防性施用抗微生物化合物例如达匹维林。 本发明的阴道内环通过利用铂催化剂（例如铂 - 硅氧烷复合物的形式）来解决先前的稳定性问题，用于交联反应。 使用含有相对小的负荷剂量的基质环，阴道环令人惊讶地在体内达到相对高且稳定的释放速率。 尽管本发明的基质环体内具有与储库环相关联的稳定释放速率，但它们制造更容易且成本更低。 本发明还提供了通过HIV逆转录酶阻断DNA聚合的方法，在女性人体中预防HIV感染的方法，在女性人体中治疗HIV感染的方法，以及制备铂催化的阴道内环的方法。
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5.发明授权Intravaginal drug delivery devices for the administration of an antimicrobial agent 有权用于给予抗微生物剂的阴道内药物递送装置公开(公告)号：US06951654B2
公开(公告)日：2005-10-04
申请号：US10107997
申请日：2002-03-27
Applicant: Karl Malcolm , David Woolfson , Grant Elliott , Martin Shephard
Inventor： Karl Malcolm , David Woolfson , Grant Elliott , Martin Shephard
IPC: A61K9/02 , A61K9/00 , A61K31/40 , A61K31/4164 , A61K31/522 , A61K31/65 , A61K31/7036 , A61K47/32 , A61K47/36 , A61K47/38 , A61P15/02 , A61P31/04 , A61F6/06 , A61F6/14
CPC classification number: A61K9/0036
Abstract: An intravaginal antimicrobial drug delivery device is disclosed having an antimicrobial agent dispersed throughout a biocompatible elastomeric system. Also disclosed is a method of making the antimicrobial drug delivery device.
Abstract translation: 公开了一种阴道内抗微生物药物递送装置，其具有分散在整个生物相容弹性系统中的抗微生物剂。 还公开了制备抗微生物药物递送装置的方法。
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Patent Agency Ranking
公开(公告)号：US10016442B2
公开(公告)日：2018-07-10
申请号：US11454697
申请日：2006-06-16
Applicant: David Woolfson , Karl Malcolm
Inventor： David Woolfson , Karl Malcolm
IPC: A61K31/56 , A61K47/32 , A61K31/565 , A61K9/00 , A61K47/10
CPC classification number: A61K31/565 , A61K9/0034 , A61K31/56 , A61K47/10 , A61K47/32
Abstract: Pharmaceutical gel compositions containing estrogen for vaginal administration, as well as a method of making the same, are disclosed.
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7.发明授权公开(公告)号：US09033901B2
公开(公告)日：2015-05-19
申请号：US12885707
申请日：2010-09-20
Applicant: David Woolfson , Duncan Bain , Lee Hubbard
Inventor： David Woolfson , Duncan Bain , Lee Hubbard
CPC classification number: A61B5/1077 , A47C31/123 , A61B5/1073 , A61B5/1079 , A61B5/4561 , G01B11/28 , G01F17/00
Abstract: A measuring device to aid mattress selection has an upstanding frame with a plurality of vertically space-apart horizontal illuminated strips. A camera mounted in front of the frame takes front view and side view images of a person standing in front of the illuminated strips. These images are delivered to an associated computer having means to determine the body mass distribution and the spine curvature of the person based on the images of the strips taken by the camera and in particular based on those portions of the image of the illuminated strips blocked by the person standing in front of the illuminated strips. This information can then be used to aid in appropriate mattress selection for the person.
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公开(公告)号：US20070271705A1
公开(公告)日：2007-11-29
申请号：US10579196
申请日：2004-11-12
Applicant: David Woolfson , Padraig Hackett
Inventor： David Woolfson , Padraig Hackett
CPC classification number: B32B5/18 , A47C27/001 , A47C27/006 , A47C27/22 , A47C31/006 , B32B5/026 , B32B5/08 , B32B5/245 , B32B27/12 , B32B2262/0253 , B32B2307/724 , Y10T428/233 , Y10T442/3179 , Y10T442/3325 , Y10T442/45 , Y10T442/469
Abstract: A mattress, cushion or the like has an outer cover enclosing a resilient core. The resilient core is formed by a viscoelastic foam layer with a vapour permeable reinforcing layer of stretchable material laminated onto a top surface of the viscoelastic foam layer. The reinforcing layer prevents cracking in the top surface of the viscoelastic foam layer and provides improved heat and moisture dissipation during use. The reinforcing layer is preferably formed by a spaced knitted fabric.
Abstract translation: 床垫，衬垫等具有包围弹性芯的外盖。 弹性芯由粘弹性泡沫层形成，粘弹性泡沫层具有层压在粘弹性泡沫层的顶表面上的可膨胀材料的透气增强层。 增强层可防止粘弹性泡沫层顶表面的破裂，并在使用过程中提供改善的热量和湿度。 增强层优选由间隔开的针织物形成。
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公开(公告)号：US08561233B2
公开(公告)日：2013-10-22
申请号：US12678124
申请日：2008-09-15
Applicant: William Navan , David Woolfson
Inventor： William Navan , David Woolfson
CPC classification number: A47G9/0207 , A47C21/046 , A47G9/10 , A47G2009/001 , B32B37/12 , B32B37/18 , Y10S5/939 , Y10T156/10
Abstract: A hermetically sealed infection control bedding product such as a pillow, duvet, mattress, cushion or such like having a sealed cover and having a resiliently deformable filling material, comprising a vent means in the cover, characterized in that the vent means comprises a filter medium including a filter membrane for the removal of particles of microbial size and wherein the filter medium also comprises a strengthening layer of material for providing mechanical strength to the filter medium whereby the filter medium allows air flow therethrough but is substantially impermeable to liquid while maintaining a barrier to particles of microbial size.
Abstract translation: 一种气密密封的感染控制床上用品，例如具有密封盖并具有可弹性变形的填充材料的枕头，羽绒被，床垫，衬垫等，其包括在盖中的通气装置，其特征在于，排气装置包括过滤介质 包括用于去除微生物尺寸的微粒的过滤膜，并且其中过滤介质还包括用于向过滤介质提供机械强度的强化层，由此过滤介质允许空气流过其中，但是在保持屏障的同时基本上不透液体 到微生物大小的颗粒。
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公开(公告)号：US20070004693A1
公开(公告)日：2007-01-04
申请号：US11454473
申请日：2006-06-16
Applicant: David Woolfson , Claire Gilligan
Inventor： David Woolfson , Claire Gilligan
CPC classification number: A61K31/565 , A61K9/0034 , A61K31/56 , A61K47/38
Abstract: Pharmaceutical gel compositions containing estrogen for vaginal administration, as well as a method of making the same, are disclosed.
Abstract translation: 公开了含有雌激素用于阴道给药的药物凝胶组合物及其制备方法。
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