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1.发明授权Rapid, efficient purification of HSV-specific T-lymphocytes and HSV antigens identified via same 有权通过相同鉴定的HSV特异性T淋巴细胞和HSV抗原的快速，有效的纯化公开(公告)号：US09138473B2
公开(公告)日：2015-09-22
申请号：US13471272
申请日：2012-05-14
Applicant: David M. Koelle , Zhi Liu , Lawrence Corey
Inventor： David M. Koelle , Zhi Liu , Lawrence Corey
IPC: A61K39/245 , C07K14/005 , C12N7/01 , A61P37/04 , C07K14/035 , A61P31/22 , C12N15/38 , C07K7/06 , C12N7/00 , A61K39/00
CPC classification number: A61K39/245 , A61K39/12 , A61K2039/5158 , A61K2039/5256 , C07K14/005 , C12N7/00 , C12N2710/16622 , C12N2710/16634 , C12N2710/24143
Abstract: A method of identifying an immunologically active antigen of a virus that attacks skin, as well as a method of enriching a population of lymphocytes for T lymphocytes that are specific to a virus that attacks skin. Also provided are HSV antigens and epitopes that are useful for the prevention and treatment of HSV infection that have been identified via the methods of the invention. T-cells having specificity for antigens of the invention have demonstrated cytotoxic activity against cells loaded with virally-encoded peptide epitopes, and in many cases, against cells infected with HSV. The identification of immunogenic antigens responsible for T-cell specificity provides improved anti-viral therapeutic and prophylactic strategies. Compositions containing antigens or polynucleotides encoding antigens of the invention provide effectively targeted vaccines for prevention and treatment of HSV infection.
Abstract translation: 识别攻击皮肤的病毒的免疫活性抗原的方法，以及对侵袭皮肤的病毒特异性的T淋巴细胞的淋巴细胞群富集的方法。 还提供了可用于预防和治疗已经通过本发明的方法鉴定的HSV感染的HSV抗原和表位。 对本发明的抗原具有特异性的T细胞已经证明了对负载有病毒编码的肽表位的细胞的细胞毒性活性，并且在许多情况下，针对感染HSV的细胞。 鉴定负责T细胞特异性的免疫原性抗原提供了改进的抗病毒治疗和预防策略。 含有编码本发明抗原的抗原或多核苷酸的组合物提供有效靶向的疫苗，用于预防和治疗HSV感染。
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2.发明申请RAPID, EFFICIENT PURIFICATION OF HSV-SPECIFIC T-LYMPHOCYTES AND HSV ANTIGENS IDENTIFIED VIA SAME 有权快速，有效地纯化HSV特异性T淋巴细胞和HSV抗原鉴定公开(公告)号：US20090148468A1
公开(公告)日：2009-06-11
申请号：US12233280
申请日：2008-09-18
Applicant: David M. Koelle , Zhi Liu , Lawrence Corey
Inventor： David M. Koelle , Zhi Liu , Lawrence Corey
IPC: A61K39/245 , C07K7/06 , C07K7/08 , A61K31/7088 , C12N7/01 , A61P31/22 , C07H21/00 , C07K14/035
CPC classification number: A61K39/245 , A61K39/12 , A61K2039/5158 , A61K2039/5256 , C07K14/005 , C12N7/00 , C12N2710/16622 , C12N2710/16634 , C12N2710/24143
Abstract: Described is a method of identifying an immunologically active antigen of a virus that attacks skin, as well as a method of enriching a population of lymphocytes for T lymphocytes that are specific to a virus that attacks skin. Also provided are HSV antigens and epitopes that are useful for the prevention and treatment of HSV infection that have been identified via the methods of the invention. T-cells having specificity for antigens of the invention have demonstrated cytotoxic activity against cells loaded with virally-encoded peptide epitopes, and in many cases, against cells infected with HSV. The identification of immunogenic antigens responsible for T-cell specificity provides improved anti-viral therapeutic and prophylactic strategies. Compositions containing antigens or polynucleotides encoding antigens of the invention provide effectively targeted vaccines for prevention and treatment of HSV infection.
Abstract translation: 描述了鉴定攻击皮肤的病毒的免疫活性抗原的方法，以及对侵袭皮肤的病毒特异性的T淋巴细胞的淋巴细胞群富集的方法。 还提供了可用于预防和治疗已经通过本发明的方法鉴定的HSV感染的HSV抗原和表位。 对本发明的抗原具有特异性的T细胞已经证明了对负载有病毒编码的肽表位的细胞的细胞毒性活性，并且在许多情况下，针对感染HSV的细胞。 鉴定负责T细胞特异性的免疫原性抗原提供了改进的抗病毒治疗和预防策略。 含有编码本发明抗原的抗原或多核苷酸的组合物提供有效靶向的疫苗，用于预防和治疗HSV感染。
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3.发明申请公开(公告)号：US20130011425A1
公开(公告)日：2013-01-10
申请号：US13471272
申请日：2012-05-14
Applicant: David M. Koelle , Zhi Liu , Lawrence Corey
Inventor： David M. Koelle , Zhi Liu , Lawrence Corey
IPC: A61K39/245 , C12N7/01 , A61P37/04 , C07K14/035 , A61P31/22 , C12N15/38 , C07K7/06
CPC classification number: A61K39/245 , A61K39/12 , A61K2039/5158 , A61K2039/5256 , C07K14/005 , C12N7/00 , C12N2710/16622 , C12N2710/16634 , C12N2710/24143
Abstract: Described is a method of identifying an immunologically active antigen of a virus that attacks skin, as well as a method of enriching a population of lymphocytes for T lymphocytes that are specific to a virus that attacks skin. Also provided are HSV antigens and epitopes that are useful for the prevention and treatment of HSV infection that have been identified via the methods of the invention. T-cells having specificity for antigens of the invention have demonstrated cytotoxic activity against cells loaded with virally-encoded peptide epitopes, and in many cases, against cells infected with HSV. The identification of immunogenic antigens responsible for T-cell specificity provides improved anti-viral therapeutic and prophylactic strategies. Compositions containing antigens or polynucleotides encoding antigens of the invention provide effectively targeted vaccines for prevention and treatment of HSV infection.
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4.发明申请RAPID, EFFICIENT PURIFICATION OF HSV-SPECIFIC T-LYMPHOCYTES AND HSV ANTIGENS IDENTIFIED VIA SAME 有权快速，有效地纯化HSV特异性T淋巴细胞和HSV抗原鉴定公开(公告)号：US20110135687A1
公开(公告)日：2011-06-09
申请号：US12691309
申请日：2010-01-21
Applicant: David M. Koelle , Zhi Liu , Lawrence Corey
Inventor： David M. Koelle , Zhi Liu , Lawrence Corey
IPC: A61K39/245 , C07K14/005 , C07H21/00 , A61K31/7088 , A61K38/16 , A61P31/12
CPC classification number: A61K39/245 , A61K39/12 , A61K2039/5158 , A61K2039/5256 , C07K14/005 , C12N7/00 , C12N2710/16622 , C12N2710/16634 , C12N2710/24143
Abstract: Described is a method of identifying an immunologically active antigen of a virus that attacks skin, as well as a method of enriching a population of lymphocytes for T lymphocytes that are specific to a virus that attacks skin. Also provided are HSV antigens and epitopes that are useful for the prevention and treatment of HSV infection that have been identified via the methods of the invention. T-cells having specificity for antigens of the invention have demonstrated cytotoxic activity against cells loaded with virally-encoded peptide epitopes, and in many cases, against cells infected with HSV. The identification of immunogenic antigens responsible for T-cell specificity provides improved anti-viral therapeutic and prophylactic strategies. Compositions containing antigen or polynucleotides encoding antigens of the invention provide effectively targeted vaccines for prevention and treatment of HSV infection.
Abstract translation: 描述了鉴定攻击皮肤的病毒的免疫活性抗原的方法，以及对侵袭皮肤的病毒特异性的T淋巴细胞的淋巴细胞群富集的方法。 还提供了可用于预防和治疗已经通过本发明的方法鉴定的HSV感染的HSV抗原和表位。 对本发明的抗原具有特异性的T细胞已经证明了对负载有病毒编码的肽表位的细胞的细胞毒性活性，并且在许多情况下，针对感染HSV的细胞。 鉴定负责T细胞特异性的免疫原性抗原提供了改进的抗病毒治疗和预防策略。 含有编码本发明抗原的抗原或多核苷酸的组合物提供有效靶向的疫苗，用于预防和治疗HSV感染。
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5.发明授权Rapid, efficient purification of HSV-specific T-lymphocytes and HSV antigens identified via same 有权通过相同鉴定的HSV特异性T淋巴细胞和HSV抗原的快速，有效的纯化公开(公告)号：US08197824B2
公开(公告)日：2012-06-12
申请号：US12691309
申请日：2010-01-21
Applicant: David M. Koelle , Zhi Liu , Lawrence Corey
Inventor： David M. Koelle , Zhi Liu , Lawrence Corey
IPC: A61K39/245
CPC classification number: A61K39/245 , A61K39/12 , A61K2039/5158 , A61K2039/5256 , C07K14/005 , C12N7/00 , C12N2710/16622 , C12N2710/16634 , C12N2710/24143
Abstract: Described is a method of identifying an immunologically active antigen of a virus that attacks skin, as well as a method of enriching a population of lymphocytes for T lymphocytes that are specific to a virus that attacks skin. Also provided are HSV antigens and epitopes that are useful for the prevention and treatment of HSV infection that have been identified via the methods of the invention. T-cells having specificity for antigens of the invention have demonstrated cytotoxic activity against cells loaded with virally-encoded peptide epitopes, and in many cases, against cells infected with HSV. The identification of immunogenic antigens responsible for T-cell specificity provides improved anti-viral therapeutic and prophylactic strategies. Compositions containing antigen or polynucleotides encoding antigens of the invention provide effectively targeted vaccines for prevention and treatment of HSV infection.
Abstract translation: 描述了鉴定攻击皮肤的病毒的免疫活性抗原的方法，以及对侵袭皮肤的病毒特异性的T淋巴细胞的淋巴细胞群富集的方法。 还提供了可用于预防和治疗已经通过本发明的方法鉴定的HSV感染的HSV抗原和表位。 对本发明的抗原具有特异性的T细胞已经证明了对负载有病毒编码的肽表位的细胞的细胞毒性活性，并且在许多情况下，针对感染HSV的细胞。 鉴定负责T细胞特异性的免疫原性抗原提供了改进的抗病毒治疗和预防策略。 含有编码本发明抗原的抗原或多核苷酸的组合物提供有效靶向的疫苗，用于预防和治疗HSV感染。
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Patent Agency Ranking
6.发明授权公开(公告)号：US07078041B2
公开(公告)日：2006-07-18
申请号：US10623429
申请日：2003-07-18
Applicant: David M. Koelle , Zhi Liu , Lawrence Corey
Inventor： David M. Koelle , Zhi Liu , Lawrence Corey
IPC: A61K39/245
CPC classification number: A61K39/245 , A61K39/12 , A61K2039/5158 , A61K2039/5256 , C07K14/005 , C12N7/00 , C12N2710/16622 , C12N2710/16634 , C12N2710/24143
Abstract: Described is a method of identifying an immunologically active antigen of a virus that attacks skin, as well as a method of enriching a population of lymphocytes for T lymphocytes that are specific to a virus that attacks skin. Also provided are HSV antigens and epitopes that are useful for the prevention and treatment of HSV infection that have been identified via the methods of the invention. T-cells having specificity for antigens of the invention have demonstrated cytotoxic activity against cells loaded with virally-encoded peptide epitopes, and in many cases, against cells infected with HSV. The identification of immunogenic antigens responsible for T-cell specificity provides improved anti-viral therapeutic and prophylactic strategies. Compositions containing antigens or polynucleotides encoding antigens of the invention provide effectively targeted vaccines for prevention and treatment of HSV infection.
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7.发明授权Rapid, efficient purification of HSV-specific T-lymphocytes and HSV antigens identified via same 有权通过相同鉴定的HSV特异性T淋巴细胞和HSV抗原的快速，有效的纯化公开(公告)号：US07666434B2
公开(公告)日：2010-02-23
申请号：US12233280
申请日：2008-09-18
Applicant: David M. Koelle , Zhi Liu , Lawrence Corey
Inventor： David M. Koelle , Zhi Liu , Lawrence Corey
IPC: A61K39/245
CPC classification number: A61K39/245 , A61K39/12 , A61K2039/5158 , A61K2039/5256 , C07K14/005 , C12N7/00 , C12N2710/16622 , C12N2710/16634 , C12N2710/24143
Abstract: Described is a method of identifying an immunologically active antigen of a virus that attacks skin, as well as a method of enriching a population of lymphocytes for T lymphocytes that are specific to a virus that attacks skin. Also provided are HSV antigens and epitopes that are useful for the prevention and treatment of HSV infection that have been identified via the methods of the invention. T-cells having specificity for antigens of the invention have demonstrated cytotoxic activity against cells loaded with virally-encoded peptide epitopes, and in many cases, against cells infected with HSV. The identification of immunogenic antigens responsible for T-cell specificity provides improved anti-viral therapeutic and prophylactic strategies. Compositions containing antigens or polynucleotides encoding antigens of the invention provide effectively targeted vaccines for prevention and treatment of HSV infection.
Abstract translation: 描述了鉴定攻击皮肤的病毒的免疫活性抗原的方法，以及对侵袭皮肤的病毒特异性的T淋巴细胞的淋巴细胞群富集的方法。 还提供了可用于预防和治疗已经通过本发明的方法鉴定的HSV感染的HSV抗原和表位。 对本发明的抗原具有特异性的T细胞已经证明了对负载有病毒编码的肽表位的细胞的细胞毒性活性，并且在许多情况下，针对感染HSV的细胞。 鉴定负责T细胞特异性的免疫原性抗原提供了改进的抗病毒治疗和预防策略。 含有编码本发明抗原的抗原或多核苷酸的组合物提供有效靶向的疫苗，用于预防和治疗HSV感染。
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8.发明授权Rapid, efficient purification of HSV-specific T-lymphocytes and HSV antigens identified via same 有权通过相同鉴定的HSV特异性T淋巴细胞和HSV抗原的快速，有效的纯化公开(公告)号：US07431934B2
公开(公告)日：2008-10-07
申请号：US11364438
申请日：2006-02-28
Applicant: David M. Koelle , Zhi Liu , Lawrence Corey
Inventor： David M. Koelle , Zhi Liu , Lawrence Corey
IPC: A61K39/12
CPC classification number: A61K39/245 , A61K39/12 , A61K2039/5158 , A61K2039/5256 , C07K14/005 , C12N7/00 , C12N2710/16622 , C12N2710/16634 , C12N2710/24143
Abstract: Described is a method of identifying an immunologically active antigen of a virus that attacks skin, as well as a method of enriching a population of lymphocytes for T lymphocytes that are specific to a virus that attacks skin. Also provided are HSV antigens and epitopes that are useful for the prevention and treatment of HSV infection that have been identified via the methods of the invention. T-cells having specificity for antigens of the invention have demonstrated cytotoxic activity against cells loaded with virally-encoded peptide epitopes, and in many cases, against cells infected with HSV. The identification of immunogenic antigens responsible for T-cell specificity provides improved anti-viral therapeutic and prophylactic strategies. Compositions containing antigens or polynucleotides encoding antigens of the invention provide effectively targeted vaccines for prevention and treatment of HSV infection.
Abstract translation: 描述了鉴定攻击皮肤的病毒的免疫活性抗原的方法，以及对侵袭皮肤的病毒特异性的T淋巴细胞的淋巴细胞群富集的方法。 还提供了可用于预防和治疗已经通过本发明的方法鉴定的HSV感染的HSV抗原和表位。 对本发明的抗原具有特异性的T细胞已经证明了对负载有病毒编码的肽表位的细胞的细胞毒性活性，并且在许多情况下，针对感染HSV的细胞。 鉴定负责T细胞特异性的免疫原性抗原提供了改进的抗病毒治疗和预防策略。 含有编码本发明抗原的抗原或多核苷酸的组合物提供有效靶向的疫苗，用于预防和治疗HSV感染。
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9.发明授权Immunologically significant herpes simplex virus antigens and methods for identifying and using same 失效免疫学上显着的单纯疱疹病毒抗原及其鉴定和使用方法公开(公告)号：US06962709B2
公开(公告)日：2005-11-08
申请号：US10117476
申请日：2002-04-05
Applicant: David M. Koelle , Hongbo Chen , Lawrence Corey , Nancy Ann Hosken , Patrick McGowan , Steven P. Fling , Christine M. Posavad
Inventor： David M. Koelle , Hongbo Chen , Lawrence Corey , Nancy Ann Hosken , Patrick McGowan , Steven P. Fling , Christine M. Posavad
IPC: G01N33/50 , A61K35/12 , A61K39/00 , A61K39/245 , A61K39/25 , A61K39/39 , A61P31/22 , C07K14/035 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N7/00 , C12N15/09 , C12N15/38 , C12P21/02 , G01N33/15 , G01N33/569 , C12P21/00 , C12P15/33 , C12P15/34 , C12P15/36
CPC classification number: C07K14/005 , A61K35/12 , A61K39/00 , A61K39/12 , A61K39/245 , A61K2039/5154 , A61K2039/53 , C12N2710/16622 , C12N2710/16634 , C12N2710/24143
Abstract: The invention provides HSV antigens that are useful for the prevention and treatment of HSV infection. Disclosed herein are epitopes confirmed to be recognized by T-cells derived from herpetic lesions. T-cells having specificity for antigens of the invention have demonstrated cytotoxic activity against cells loaded with virally-encoded peptide epitopes, and in many cases, against cells infected with HSV. The identification of immunogenic antigens responsible for T-cell specificity provides improved anti-viral therapeutic and prophylactic strategies. Compositions containing antigens or polynucleotides encoding antigens of the invention provide effectively targeted vaccines for prevention and treatment of HSV infection.
Abstract translation: 本发明提供可用于预防和治疗HSV感染的HSV抗原。 本文公开了证实由来自疱疹病变的T细胞识别的表位。 对本发明的抗原具有特异性的T细胞已经证明了对负载有病毒编码的肽表位的细胞的细胞毒性活性，并且在许多情况下，针对感染HSV的细胞。 鉴定负责T细胞特异性的免疫原性抗原提供了改进的抗病毒治疗和预防策略。 含有编码本发明抗原的抗原或多核苷酸的组合物提供有效靶向的疫苗，用于预防和治疗HSV感染。
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10.发明授权公开(公告)号：US06855317B2
公开(公告)日：2005-02-15
申请号：US10073834
申请日：2002-02-11
Applicant: David M. Koelle , Lawrence Corey
Inventor： David M. Koelle , Lawrence Corey
IPC: C12N15/09 , A61K31/711 , A61K35/76 , A61K38/00 , A61K39/00 , A61P31/22 , C07K14/035 , C07K19/00 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N7/00 , C12N7/01 , C12N15/34 , C12N15/38 , C12P21/02 , C12R1/91 , C12R1/93 , C12N15/86
CPC classification number: C07K14/005 , A61K39/00 , A61K2039/55572 , A61K2039/57 , C07K2319/00 , C12N2710/16622 , C12N2710/16634
Abstract: The invention provides HSV antigens that are useful for the prevention and treatment of HSV infection. Disclosed herein are antigens and/or their constituent epitopes confirmed to be recognized by T-cells derived from herpetic lesions or from uterine cervix. T-cells having specificity for antigens of the invention have demonstrated cytotoxic activity against cells loaded with virally-encoded peptide epitopes, and in many cases, against cells infected with HSV. The identification of immunogenic antigens responsible for T-cell specificity provides improved anti-viral therapeutic and prophylactic strategies. Compositions containing antigens or polynucleotides encoding antigens of the invention provide effectively targeted vaccines for prevention and treatment of HSV infection.
Abstract translation: 本发明提供可用于预防和治疗HSV感染的HSV抗原。 本文公开了抗原和/或其组成表位，其被证实被来自疱疹病变或子宫颈的T细胞识别。 对本发明的抗原具有特异性的T细胞已经证明了对负载有病毒编码的肽表位的细胞的细胞毒性活性，并且在许多情况下，针对感染HSV的细胞。 鉴定负责T细胞特异性的免疫原性抗原提供了改进的抗病毒治疗和预防策略。 含有编码本发明抗原的抗原或多核苷酸的组合物提供有效靶向的疫苗，用于预防和治疗HSV感染。
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