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    Phosphoramidite derivatives of texaphyrins
    2.
    发明授权
    Phosphoramidite derivatives of texaphyrins 失效
    泰克萨菲瑞的亚磷酰胺衍生物

    公开(公告)号：US5633354A

    公开(公告)日：1997-05-27

    申请号：US614638

    申请日：1996-03-13

    申请人： Darren Magda ,  Jonathan L. Sessler ,  Brent L. Iverson ,  Petra I. Sansom ,  Shaun P. Crofts

    发明人： Darren Magda ,  Jonathan L. Sessler ,  Brent L. Iverson ,  Petra I. Sansom ,  Shaun P. Crofts

    IPC分类号： C07H21/00 ,  C07F7/00 ,  C07F9/6524 ,  C07D187/22

    CPC分类号： C07H21/00 ,  A61K47/48069

    摘要： The invention is directed to a method of incorporating expanded porphyrins, and particularly of incorporating a sapphyrin or a texaphyrin, before, during, or after chemical synthesis of an oligomer to form an expanded porphyrin-oligonucleotide conjugate, and particularly a sapphyrin- or texaphyrin-oligonucleotide conjugate. This method includes reacting derivatized nucleotides and a sapphyrin or a texaphyrin in a desired order in an automated or manual DNA synthesizer having a solid support to form a sapphyrin- or a texaphyrin-oligonucleotide conjugate.

    摘要翻译： 本发明涉及在低聚物的化学合成之前，期间或之后掺入膨胀的卟啉，特别是引入卟啉或特沙弗林的方法，以形成发泡的卟啉 - 寡核苷酸缀合物，特别是卟啉 - 或泰克萨菲瑞 - 寡核苷酸缀合物。 该方法包括在具有固体支持物的自动或手动DNA合成仪中以期望的顺序使衍生化的核苷酸与泰夫沙弗反应形成卟啉或泰克萨菲瑞 - 寡核苷酸缀合物。

    WATER-SOLUBLE ZINC IONOPHORES, ZINC CHELATORS, AND/OR ZINC COMPLEXES AND USE FOR TREATING CANCER
    4.
    发明申请
    WATER-SOLUBLE ZINC IONOPHORES, ZINC CHELATORS, AND/OR ZINC COMPLEXES AND USE FOR TREATING CANCER 有权
    水溶性锌离子，锌化合物和/或锌化合物复合物和用于治疗癌症

    公开(公告)号：US20110034431A1

    公开(公告)日：2011-02-10

    申请号：US12905823

    申请日：2010-10-15

    申请人： Darren Magda ,  Jonathan L. Sessler

    发明人： Darren Magda ,  Jonathan L. Sessler

    IPC分类号： A61K31/555 ,  C07F3/06 ,  A61P35/00

    CPC分类号： C07D213/89 ,  C07D491/08

    摘要： Disclosed herein are novel zinc ionophores, zinc chelators and/or zinc complexes with enhanced aqueous solubility. Methods of treating cancer using at least one zinc ionophore and/or zinc chelator are also disclosed. Also disclosed herein are compositions and methods for treating cancer with combination therapy using at least one texaphyrin metal complex and at least one zinc ionophore or the respective pharmaceutically acceptable derivatives or salts thereof.

    摘要翻译： 本文公开了具有增强的水溶性的新型锌离子载体，锌螯合剂和/或锌络合物。 还公开了使用至少一种锌离子载体和/或锌螯合剂治疗癌症的方法。 本文还公开了使用至少一种泰克萨菲瑞金属络合物和至少一种锌离子载体或其各自的药学上可接受的衍生物或盐的联合治疗来治疗癌症的组合物和方法。

    Water-soluble zinc ionophores, zinc chelators, and/or zinc complexes and use for treating cancer
    6.
    发明授权
    Water-soluble zinc ionophores, zinc chelators, and/or zinc complexes and use for treating cancer 有权
    水溶性锌离子载体，锌螯合剂和/或锌络合物，用于治疗癌症

    公开(公告)号：US07528125B2

    公开(公告)日：2009-05-05

    申请号：US11688789

    申请日：2007-03-20

    申请人： Darren Magda ,  Jonathan L. Sessler

    发明人： Darren Magda ,  Jonathan L. Sessler

    IPC分类号： A61K31/555 ,  C07F3/06

    CPC分类号： C07D213/89 ,  C07D491/08

    摘要： Disclosed herein are novel zinc ionophores, zinc chelators and/or zinc complexes with enhanced aqueous solubility. Methods of treating cancer using at least one zinc ionophore and/or zinc chelator are also disclosed. Also disclosed herein are compositions and methods for treating cancer with combination therapy using at least one texaphyrin metal complex and at least one zinc ionophore or the respective pharmaceutically acceptable derivatives or salts thereof.

    摘要翻译： 本文公开了具有增强的水溶性的新型锌离子载体，锌螯合剂和/或锌络合物。 还公开了使用至少一种锌离子载体和/或锌螯合剂治疗癌症的方法。 本文还公开了使用至少一种泰克萨菲瑞金属络合物和至少一种锌离子载体或其各自的药学上可接受的衍生物或盐的联合治疗来治疗癌症的组合物和方法。

    Membrane incorporation of texaphyrins
    7.
    发明授权
    Membrane incorporation of texaphyrins 失效
    丝裂霉素的膜结合

    公开(公告)号：US06375930B2

    公开(公告)日：2002-04-23

    申请号：US08975090

    申请日：1997-11-20

    申请人： Stuart W. Young ,  Meredith Wright ,  Jonathan L. Sessler ,  Tarak D. Mody ,  Darren Magda

    发明人： Stuart W. Young ,  Meredith Wright ,  Jonathan L. Sessler ,  Tarak D. Mody ,  Darren Magda

    IPC分类号： A61B55055

    CPC分类号： B82Y5/00 ,  A61K41/0076 ,  A61K47/554 ,  A61K47/6901 ,  A61K47/6911 ,  A61K49/085 ,  A61K49/1896

    摘要： Compositions having a texaphyrin-lipophilic molecule conjugate loaded into a biological vesicle and methods for imaging, diagnosis and treatment using the loaded vesicle are provided. For example, liposomes or red blood cells loaded with a paramagnetic texaphyrin-lipophilic molecule conjugate have utility as a blood pool contrast agent, facilitating the enhancement of normal tissues, magnetic resonance angiography, and marking areas of damaged endothelium by their egress through fenestrations or damaged portions of the blood vascular system. Liposomes or cells loaded with a photosensitive texaphyrin-lipophilic molecule conjugate can be photolysed, allowing for a photodynamic therapy effect at the site of lysis. Availability of red blood cells loaded with a photosensitive texaphyrin-lipophilic molecule conjugate provides a method for delivering a photodynamic therapeutic agent to a desired site with a high concentration of oxygen. By presenting the agent in this way, it is expected that a patient will experience less toxicity.

    摘要翻译： 提供了具有加载到生物囊泡中的泰克萨菲瑞 - 亲脂性分子缀合物的组合物以及使用加载的囊泡进行成像，诊断和治疗的方法。 例如，装载有顺磁性泰克萨菲瑞 - 亲脂性分子缀合物的脂质体或红细胞具有作为血液池造影剂的效用，有利于正常组织的增强，磁共振血管造影术，以及通过开窗口或损伤引起的出血损伤的内皮标记区域 部分血管系统。 可以光密化具有感光性泰克萨菲瑞 - 亲脂性分子缀合物的脂质体或细胞，从而在裂解部位产生光动力学治疗效果。 载有感光性泰克萨菲瑞 - 亲脂性分子缀合物的红细胞的可获得性提供了一种将光动力治疗剂递送至具有高浓度氧的所需部位的方法。 通过以这种方式呈现代理，预期患者的毒性将较低。

    Multi-mechanistic chemical cleavage using certain metal complexes
    8.
    发明授权
    Multi-mechanistic chemical cleavage using certain metal complexes 失效
    使用某些金属络合物进行多机械化学裂解

    公开(公告)号：US5798491A

    公开(公告)日：1998-08-25

    申请号：US458347

    申请日：1995-06-02

    申请人： Darren Magda ,  Jonathan L. Sessler

    发明人： Darren Magda ,  Jonathan L. Sessler

    IPC分类号： C12N15/09 ,  A61K31/40 ,  A61K31/70 ,  A61K41/00 ,  A61K47/48 ,  A61K48/00 ,  A61K49/00 ,  A61P31/12 ,  A61P35/00 ,  B01J31/18 ,  C07D487/22 ,  C07H21/00 ,  C07H21/02 ,  C07H21/04 ,  C12N15/113 ,  C07B61/00

    CPC分类号： C12N15/113 ,  A61K41/0038 ,  A61K41/0042 ,  A61K41/0076 ,  A61K47/48069 ,  A61K49/0021 ,  B01J31/1815 ,  C07D487/22 ,  C07H21/00 ,  B01J2531/025 ,  B01J2531/36 ,  C12N2310/15 ,  C12N2310/321 ,  C12N2310/3511

    摘要： The invention is directed to a particular class of metal complexes, specifically certain texaphyrin metal complexes, which both hydrolyze and photocleave RNA, and which also both hydrolyze RNA and photocleave DNA. In one embodiment, the present invention is directed to a method for both hydrolyzing and photocleaving a polymer of ribonucleic acid, the method comprising the steps of contacting the polymer of ribonucleic acid with a texaphyrin metal complex exhibiting catalytic activity for both hydrolysis and photocleavage of ribonucleic acid polymers, incubating the polymer and the metal complex under conditions and for a time sufficient to hydrolyze the phosphate ester bond of the polymer, and exposing the texaphyrin metal complex to light for a time sufficient to photocleave the polymer. In another embodiment of the present invention, the invention is directed to a method for both hydrolyzing a polymer of ribonucleic acid and photocleaving a polymer of deoxyribonucleic acid, the method comprising the steps of contacting a mixture of the ribonucleic acid polymer and the deoxyribonucleic acid polymer with a texaphyrin metal complex exhibiting catalytic activity for both hydrolysis of ribonucleic acid polymers and photocleavage of deoxyribonucleic acid polymers, incubating the polymer mixture and the metal complex under conditions and for a time sufficient to hydrolyze the phosphate ester bond of the ribonucleic acid polymer, and exposing the texaphyrin metal complex to light for a time sufficient to photocleave the deoxyribonucleic acid polymer.

    摘要翻译： 本发明涉及特定类别的金属络合物，特别是某些泰克萨菲瑞金属络合物，它们水解和脱色RNA，并且还水解RNA和光切割DNA。 在一个实施方案中，本发明涉及水解和光切割核糖核酸聚合物的方法，所述方法包括以下步骤：使核糖核酸的聚合物与表现出用于核糖核酸的水解和光切割的催化活性的泰克萨菲瑞金属络合物 酸性聚合物，在足以水解聚合物的磷酸酯键的条件和时间下孵育聚合物和金属络合物，并将泰克萨菲瑞金属络合物暴露于光下足以使聚合物光滑的时间。 在本发明的另一个实施方案中，本发明涉及水解核糖核酸聚合物和光切割脱氧核糖核酸聚合物的方法，该方法包括以下步骤：使核糖核酸聚合物和脱氧核糖核酸聚合物 具有表现出对核糖核酸聚合物的水解和脱氧核糖核酸聚合物的光切割的催化活性的特沙弗林金属络合物，在足以水解核糖核酸聚合物的磷酸酯键的条件和时间下孵育聚合物混合物和金属络合物，以及 将泰克萨菲芬金属络合物曝光一段足以使脱氧核糖核酸聚合物光滑的时间。