公开(公告)号：US20200085888A1

公开(公告)日：2020-03-19

申请号：US16333770

申请日：2017-09-12

Applicant: DUPONT NUTRITION BIOSCIENCES APS

Inventor： Heli Putaala ,  Sofia Forssten ,  Sampo Lahtinen ,  Arthur Ouwehand ,  Jaana Mättö ,  Harri Mäkivuokko ,  Janne Nikkilä

IPC: A61K35/747 ,  A61K35/745 ,  A61P1/04 ,  A61P1/14 ,  A23L33/00 ,  A23L33/135 ,  A61P1/12

Abstract: The present invention relates to bacteria and metabolites thereof that are capable of binding to A, B and/or O blood type antigens or which are acid and/or bile tolerant, their use in probiotic compositions and food products, and methods for their selection. The invention also relates to the use of said bacteria and metabolites for the prevention and/or treatment of gastrointestinal disorders.

公开(公告)号：US20240245735A1

公开(公告)日：2024-07-25

申请号：US18364151

申请日：2023-08-02

Applicant: DUPONT NUTRITION BIOSCIENCES APS

Inventor： Heli Putaala ,  Sofia Forssten ,  Sampo Lahtinen ,  Arthur Ouwehand ,  Jaana Mättö ,  Harri Mäkivuokko ,  Janne Nikkilä

IPC: A61K35/747 ,  A23L33/00 ,  A23L33/135 ,  A61K35/745 ,  A61P1/04 ,  A61P1/12 ,  A61P1/14

CPC classification number: A61K35/747 ,  A23L33/135 ,  A23L33/30 ,  A61K35/745 ,  A61P1/04 ,  A61P1/12 ,  A61P1/14

Abstract: The present invention relates to bacteria and metabolites thereof that are capable of binding to A, B and/or O blood type antigens or which are acid and/or bile tolerant, their use in probiotic compositions and food products, and methods for their selection. The invention also relates to the use of said bacteria and metabolites for the prevention and/or treatment of gastrointestinal disorders.

公开(公告)号：US10543239B2

公开(公告)日：2020-01-28

申请号：US14983827

申请日：2015-12-30

Applicant: DUPONT NUTRITION BIOSCIENCES APS

Inventor： Remy Burcelin ,  Didier Carcano ,  Pierre Desreumaux ,  Sampo Lahtinen ,  Nina Rautonen ,  Heli Putaala ,  Kirsti Tiihonen ,  Rodolphe Barrangou

IPC: A61K35/747 ,  A61K35/745 ,  A61K35/74 ,  A61K35/00

Abstract: The invention relates to use of a bacterium selected from a lactic acid bacterium, a Bifidobacterium or a mixture of any thereof for treating metabolic endotoxemia, inhibiting bacterial translocation and regulating lipid absorption in a mammal.

公开(公告)号：US20220354908A1

公开(公告)日：2022-11-10

申请号：US17579006

申请日：2022-01-19

Applicant: DUPONT NUTRITION BIOSCIENCES APS

Inventor： Heli Putaala ,  Sofia Forssten ,  Sampo Lahtinen ,  Arthur Ouwehand ,  Jaana Mättö ,  Harri Mäkivuokko ,  Inger Mattsby-Baltzer ,  Björn Andersch

IPC: A61K35/747 ,  A61P31/00 ,  C12Q1/28 ,  C12N1/20 ,  A61K35/745

Abstract: The present invention relates to bacteria and metabolites thereof that are capable of binding to vaginal cells and producing hydrogen peroxide, their use in probiotic compositions and food products and methods for their selection. The invention also relates to the use of said bacteria, metabolites and probiotic compositions for the prevention and/or treatment of urogenital disorders.

公开(公告)号：US20180295858A1

公开(公告)日：2018-10-18

申请号：US15520140

申请日：2015-10-23

Applicant: DUPONT NUTRITION BIOSCIENCES APS

Inventor： Svend Haaning ,  Karsten Matthias Kragh ,  Stepan Shipovskov ,  Andrei Miasnikov ,  Maria Ma ,  Luis Fernando Romero Millan ,  Luke Barnard ,  Shukun Yu ,  Ernst Meinjohanns ,  Steffen Bak ,  Päivi Nurminen ,  Heli Putaala

IPC: A23K10/14 ,  C12N9/48 ,  A23K20/147 ,  A23K50/75 ,  A23K50/30

Abstract: A method of preparing a feed additive composition comprising: (a) admixing at least one proline tolerant tripeptidyl peptidase predominantly having exopeptidase activity wherein said proline tolerant tripeptidyl peptidase is capable of cleaving tri-peptides from the N-terminus of peptides having (i) (A) Proline at P1; and (B) An amino acid selected from alanine, arginine, asparagine, aspartic acid, cysteine, glutamine, glutamic acid, glycine, histidine, isoleucine, leucine, lysine, methionine, phenylalanine, serine, threonine, tryptophan, tyrosine, valine or synthetic amino acids at P1; or (ii) (a′) Proline at P1′; and (b′) An amino acid selected from alanine, arginine, asparagine, aspartic acid, cysteine, glutamine, glutamic acid, glycine, histidine, isoleucine, leucine, lysine, methionine, phenylalanine, serine, threonine, tryptophan, tyrosine, valine or synthetic amino acids or amines at P1′; and one or more ingredients selected from the group consisting of a salt, polyol including sorbitol and glycerol, wheat or a wheat component, sodium acetate, sodium acetate trihydrate, potassium sorbate Talc, polyvinyl alcohol (PVA), benzoate, sorbiate, 1,3-propane diol, glucose, parabens, sodium chloride, citrate, metabisulfite, formate or a combination thereof; and (b) optionally packaging as well as uses of such proline tolerant tripeptidyl peptidases, feed additive compositions, feed additive kits, feeds or feedstuffs and/or premixes.

公开(公告)号：US20160008412A1

公开(公告)日：2016-01-14

申请号：US14860836

申请日：2015-09-22

Applicant: DUPONT NUTRITION BIOSCIENCES APS

Inventor： Heli Putaala ,  Arthur Ouwehand ,  Kirsti Tihonen ,  Nina Rautonen

IPC: A61K35/741 ,  A61K35/745 ,  A61K31/205 ,  A61K35/747

CPC classification number: A61K35/741 ,  A61K31/205 ,  A61K35/744 ,  A61K35/745 ,  A61K35/747

Abstract: The present invention relates to a probiotic bacteria, and/or soluble metabolite of a probiotic bacteria and/or a cell lysate of a probiotic bacteria for use in the treatment of a disorder associated with Tight Junction function, characterised in that the probiotic bacteria, soluble metabolite of a probiotic bacteria and/or a cell lysate of a probiotic bacteria is formulated for topical administration.

Abstract translation: 本发明涉及用于治疗与紧结功能相关的病症的益生菌和/或益生菌的细胞裂解液的益生菌和/或可溶性代谢物，其特征在于益生菌，可溶性 将益生菌和/或益生菌的细胞裂解液的代谢物配制成局部给药。