公开(公告)号：US20180362428A1

公开(公告)日：2018-12-20

申请号：US16062463

申请日：2016-12-14

申请人： DSM IP ASSETS B.V.

发明人： Igor BENDIK ,  Piero GEOTTI-BIANCHINI ,  Marc HEIDL ,  Eileen JACKSON ,  Alexander SCHLIFKE-POSCHALKO

IPC分类号： C07C33/48 ,  A61K8/34 ,  A61Q19/08 ,  C07F5/02 ,  C07C29/64

CPC分类号： C07C33/486 ,  A61K8/34 ,  A61K8/345 ,  A61K8/67 ,  A61Q19/08 ,  C07C29/64 ,  C07F5/027

摘要： Novel biaromatic compounds, which are vitamin D analogs, processes for their preparation and cosmetic, dermatological and pharmaceutical preparations containing one or more of these compounds.

公开(公告)号：US20180208576A1

公开(公告)日：2018-07-26

申请号：US15745754

申请日：2016-07-07

申请人： DSM IP ASSETS B.V.

发明人： Stéphanie BOUDON ,  Piero GEOTTI-BIANCHINI ,  Marc HEIDL ,  Eileen JACKSON ,  Alexander SCHLIFKE-POSCHALKO

IPC分类号： C07D401/10 ,  C07D265/30 ,  C07D223/04 ,  C07D211/16 ,  A61K8/49 ,  A61Q19/08

CPC分类号： C07D401/10 ,  A61K8/49 ,  A61K8/4906 ,  A61K8/4926 ,  A61Q19/08 ,  C07D211/16 ,  C07D223/04 ,  C07D265/30

摘要： The present invention relates to novel selective 11-beta-hydroxysteroid dehydrogenase type 1 (11β-HSD1) inhibitors and the use thereof to prevent age-induced skin structure and function defects.

公开(公告)号：US20200308222A1

公开(公告)日：2020-10-01

申请号：US16759851

申请日：2018-10-29

申请人： DSM IP ASSETS B.V.

发明人： Marc HEIDL ,  Eileen JACKSON

IPC分类号： C07K5/117 ,  A61K8/64 ,  A61Q5/00 ,  A61Q19/00

摘要： The present invention relates to novel tetrapeptides as well as the use thereof as antimicrobial agents.

公开(公告)号：US20180344604A1

公开(公告)日：2018-12-06

申请号：US15777987

申请日：2016-12-09

申请人： DSM IP ASSETS B.V.

发明人： Stephanie BOUDON ,  Marc HEIDL ,  Eileen JACKSON

IPC分类号： A61K8/49 ,  A61K8/42

CPC分类号： A61K8/4913 ,  A61K8/42 ,  A61K8/492 ,  A61Q19/08 ,  C07D207/16

摘要： The present invention relates to novel selective 11-beta-hydroxysteroid dehydrogenase type 1 (11ß-HSD1) inhibitors and the use thereof to prevent age-induced skin structure and function defects.

公开(公告)号：US20240239839A1

公开(公告)日：2024-07-18

申请号：US18559242

申请日：2022-05-03

申请人： DSM IP Assets B.V.

发明人： Marc HEIDL ,  Thomas SCHAERER ,  Alexander SCHLIFKE-POSCHALKO

IPC分类号： C07K1/30 ,  A61K8/64 ,  A61K38/00 ,  A61Q19/00 ,  C07K1/34

CPC分类号： C07K1/30 ,  A61K8/64 ,  A61Q19/00 ,  C07K1/34 ,  A61K38/00

摘要： The present invention relates to purification of a tripeptide of formula (I). By using said method, the tripeptide of formula (I) is obtained in a very pure form and due to this effect the purified tripeptide can be used in a variety of cosmetic and pharmaceutic compositions which are not accessible for the respective unpurified tripeptide.

公开(公告)号：US20210230220A1

公开(公告)日：2021-07-29

申请号：US15734751

申请日：2019-06-05

申请人： DSM IP Assets B.V.

发明人： Marc HEIDL ,  Piero GEOTTI-BIANCHINI

IPC分类号： C07K5/11 ,  C07K1/06 ,  C07K5/078 ,  C07K5/107 ,  C07K5/09 ,  C07K5/10

摘要： Methods for the synthesis of arginine-containing peptides are provided. The methods include a deprotection step that minimizes the transfer of by-products deriving from cleaved sulfonyl-5 based side chain protecting groups from arginine to amino acids carrying electron rich side chains.

公开(公告)号：US20190263858A1

公开(公告)日：2019-08-29

申请号：US16332506

申请日：2017-09-13

申请人： DSM IP ASSETS B.V.

发明人： Marc HEIDL ,  Eileen JACKSON

IPC分类号： C07K5/083 ,  C07K5/097

摘要： The present invention relates to novel compounds which effectively inhibit the melanin synthesis in human melanocytes and are thus suitable for the treatment of senile lentigines, for smoothening skin color irregularities and/or for lightening natural skin color.

公开(公告)号：US20240254164A1

公开(公告)日：2024-08-01

申请号：US18559251

申请日：2022-05-03

申请人： DSM IP Assets B.V.

发明人： Marc HEIDL ,  Thomas SCHAERER ,  Alexander SCHLIFKE-POSCHALKO

IPC分类号： C07K5/083 ,  A61K8/64 ,  A61K38/00 ,  A61Q19/08

CPC分类号： C07K5/081 ,  A61K8/64 ,  A61Q19/08 ,  A61K38/00 ,  A61K2800/805

摘要： The present invention relates to purification of a tripeptide of formula (I). By using said method, the tripeptide of formula (I) is obtained in a very pure form and due to this effect the purified tripeptide can be used in a variety of cosmetic and pharmaceutic compositions which are not accessible for the respective unpurified tripeptide.

公开(公告)号：US20210277058A1

公开(公告)日：2021-09-09

申请号：US16338758

申请日：2017-10-02

申请人： DSM IP ASSETS B.V.

发明人： Marc HEIDL ,  Eileen JACKSON

IPC分类号： C07K7/06 ,  A61Q19/04 ,  A61K8/64 ,  A61K8/25 ,  A61K8/29 ,  A61K8/23 ,  A61K8/27 ,  A61K8/34

摘要： The present invention relates to novel selective melanocortin-1 receptor (MC1R) agonists as well as the use thereof as skin tanning agents.

公开(公告)号：US20200290960A1

公开(公告)日：2020-09-17

申请号：US16061418

申请日：2016-12-14

申请人： DSM IP ASSETS B.V.

发明人： Igor BENDIK ,  Piero GEOTTI-BIANCHINI ,  Marc HEIDL ,  Eileen JACKSON ,  Alexander SCHLIFKE-POSCHALKO

IPC分类号： C07C401/00 ,  A61K8/34 ,  A61Q19/08

摘要： Novel biaromatic compounds, which are vitamin D analogs, processes for their preparation and cosmetic, dermatological and pharmaceutical preparations containing one or more of these compounds.