公开(公告)号：US20030021842A1

公开(公告)日：2003-01-30

申请号：US10245639

申请日：2002-09-18

申请人： DRUGTECH CORPORATION

发明人： Yury Lagoviyer ,  R. Saul Levinson ,  Denis Stotler ,  Thomas C. Riley

IPC分类号： A61K009/20

CPC分类号： A61K9/0056 ,  A61K9/1623 ,  A61K9/1658 ,  A61K9/2081 ,  Y10S514/96 ,  Y10S514/961

摘要： The present invention relates to a means for creating a mass having structural integrity, including a rapidly disintegratable tablet for administration with or without the use of water. The present invention has a wide variety of different uses and applications. One embodiment is a tablet intended for oral administration. The tablet comprises at least one active ingredient and a mixture of excipients. The excipients provide desired characteristics and physical properties and when the tablet is sintered or heated, excellent tablet binding characteristics are obtained. The tablet is intended primarily for oral administration and dissolves in the presence of water. Also disclosed is a process for the preparation of a rapidly disintegratable tablet for administration with or without the use of water. The process comprising dissolving at least one bulking agent and at least one structural agent in a suitable solvent, wherein the solvent provides high porosity upon drying; spray-drying or dispersing said dissolved mixture to obtain a bead or granulated product; dry blending at least one binding agent, and at least one active ingredient with the bead or granulated product to obtain a preformulation product or adding at least one active ingredient to the preformulation product dissolved or dispersed components before spray-drying or dispersing; compressing the preformulation product; and sintering or heating the preformulation product for a sufficient time and temperature to allow the binding agent to change status or melt and allow the binding agent to resolidify as the temperature is reduced to ambient temperature.