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公开(公告)号：US20240177984A1
公开(公告)日：2024-05-30
申请号：US18283378
申请日：2022-03-21
Applicant: DH TECHNOLOGIES DEVELOPMENT PTE. LTD.
Inventor： Bradley Schneider , Leigh Bedford , Aaron Stella , Subhasish Purkayastha
IPC: H01J49/04 , G01N1/38 , G01N27/624 , G01N33/487
CPC classification number: H01J49/0454 , G01N1/38 , G01N27/624 , G01N33/487
Abstract: Methods of detecting at least one analyte in at least one liquid sample are described. The method includes the steps of desalting the liquid sample, acoustically ejecting the desalted sample into an open-port interface, diluting the desalted sample, and transferring the diluted sample to an ionization source, ionizing the diluted sample, and selecting ions of interest by ion mobility
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公开(公告)号：US11887831B2
公开(公告)日：2024-01-30
申请号：US17312695
申请日：2019-12-12
Applicant: DH Technologies Development Pte. Ltd.
Inventor： Leigh Bedford , Yang Kang , Yves Le Blanc , Bradley Schneider
CPC classification number: H01J49/067 , H01J49/0031 , H01J49/4215
Abstract: In some embodiments, a method for optimizing performance of a mass spectrometer comprises using an ion source to generate ions, collisionally cooling the ions within an ion guide, directing said ions from the ion guide through at least one ion lens to a downstream mass analyzer, ramping a DC voltage applied to the ion lens, performing a mass analysis of the ions within the mass analyzer while the DC voltage applied to the ion lens is ramped, estimating performance of the mass spectrometer by measuring one or more characteristics of at least one of an ion signal and the voltage ramp, and adjusting a DC voltage applied to said at least one lens element based on said measured one or more characteristics of at least one of the ion signal and the voltage ramp so as to enhance performance of the mass spectrometer.
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公开(公告)号：US20220157592A1
公开(公告)日：2022-05-19
申请号：US17440131
申请日：2020-05-29
Applicant: DH Technologies Development PTE. LTD.
Inventor： Leigh Bedford , Goran Ristic , Bradley B. Schneider
Abstract: An electrospray probe for use in an electrospray ion source is disclosed, which comprises a cannula extending from a proximal end having an inlet aperture for receiving a liquid sample containing at least one analyte to a discharge emitter end having an outlet aperture through which charged liquid droplets containing ions of said analyte are discharged, and an electrically conductive coating covering at least a portion of an external surface and at least a portion of an internal surface of said emitter end.
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Patent Agency Ranking
公开(公告)号：US20250003929A1
公开(公告)日：2025-01-02
申请号：US18704236
申请日：2022-10-26
Applicant: DH TECHNOLOGIES DEVELOPMENT PTE. LTD.
Inventor： Aaron Stella , Bradley Schneider , Subhasish Purkayastha , Leigh Bedford
Abstract: Disclosed are methods for detecting and quantifying target analytes in a sample by mass analysis that include detecting the presence of ions of the target analyte in the sample and quantifying the amount of the target analyte. The methods can include one or more standards (e.g., internal and/or external standards) that may be labelled (e.g., isotopically labelled).
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5.发明公开公开(公告)号：US20240186130A1
公开(公告)日：2024-06-06
申请号：US18554840
申请日：2022-04-14
Applicant: DH Technologies Development Pte. Ltd.
Inventor： Bradley B. Schneider , Leigh Bedford
CPC classification number: H01J49/0031 , H01J49/004 , H01J49/0431
Abstract: Systems and methods are disclosed for automated method parameter configuration for differential mobility separations. As non-limiting examples, various aspects of this disclosure provide receiving a sample in an open port interface; transferring the sample to an ionization source; ionizing the transferred sample; introducing the ionized sample into a mass spectrometer; mass analyzing the ionized sample to produce an initial mass analysis result; determining a peak width of the initial mass analysis result; and determining a dwell time for subsequent measurements based on the determined peak width, a pre-defined number of data points across subsequent mass analysis peak widths, and a number of different analytes to be assessed for the sample. The sample may be diluted and transferred to the ionization source by a sample introduction apparatus selected from a group including an acoustic droplet ejector (ADE), a pneumatic ejector, a piezoelectric ejector, and a hydraulic ejector.
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公开(公告)号：US12224171B2
公开(公告)日：2025-02-11
申请号：US17440131
申请日：2020-05-29
Applicant: DH Technologies Development PTE. LTD.
Inventor： Leigh Bedford , Goran Ristic , Bradley B. Schneider
Abstract: An electrospray probe for use in an electrospray ion source is disclosed, which comprises a cannula extending from a proximal end having an inlet aperture for receiving a liquid sample containing at least one analyte to a discharge emitter end having an outlet aperture through which charged liquid droplets containing ions of said analyte are discharged, and an electrically conductive coating covering at least a portion of an external surface and at least a portion of an internal surface of said emitter end.
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公开(公告)号：US20240379338A1
公开(公告)日：2024-11-14
申请号：US18686618
申请日：2022-09-07
Applicant: DH TECHNOLOGIES DEVELOPMENT PTE. LTD.
Inventor： Bradley B. Schneider , Leigh Bedford , Chang Liu
IPC: H01J49/04 , G01N27/624 , H01J49/00
Abstract: Disclosed are methods and systems that provide for the analysis of one or more analytes of interest in an acoustic ejection mass spectrometer (AEMS) system that incorporates an open port interface (OPI) and differentiation mass spectrometry (DMS) that allows for operation of the system in a pseudo-continuous mode to scan and determine optimal DMS settings for the one or more analytes of interest, and for operation of the system in a discontinuous mode to analyze for the presence of the one or more analytes of interest in a sample.
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公开(公告)号：US20220059334A1
公开(公告)日：2022-02-24
申请号：US17312695
申请日：2019-12-12
Applicant: DH Technologies Development Pte. Ltd.
Inventor： Leigh Bedford , Yang Kang , Yves Le Blanc , Bradley Schneider
Abstract: In some embodiments, a method for optimizing performance of a mass spectrometer comprises using an ion source to generate ions, collisionally cooling the ions within an ion guide, directing said ions from the ion guide through at least one ion lens to a downstream mass analyzer, ramping a DC voltage applied to the ion lens, performing a mass analysis of the ions within the mass analyzer while the DC voltage applied to the ion lens is ramped, estimating performance of the mass spectrometer by measuring one or more characteristics of at least one of an ion signal and the voltage ramp, and adjusting a DC voltage applied to said at least one lens element based on said measured one or more characteristics of at least one of the ion signal and the voltage ramp so as to enhance performance of the mass spectrometer.
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