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公开(公告)号：US20220059334A1
公开(公告)日：2022-02-24
申请号：US17312695
申请日：2019-12-12
Applicant: DH Technologies Development Pte. Ltd.
Inventor： Leigh Bedford , Yang Kang , Yves Le Blanc , Bradley Schneider
Abstract: In some embodiments, a method for optimizing performance of a mass spectrometer comprises using an ion source to generate ions, collisionally cooling the ions within an ion guide, directing said ions from the ion guide through at least one ion lens to a downstream mass analyzer, ramping a DC voltage applied to the ion lens, performing a mass analysis of the ions within the mass analyzer while the DC voltage applied to the ion lens is ramped, estimating performance of the mass spectrometer by measuring one or more characteristics of at least one of an ion signal and the voltage ramp, and adjusting a DC voltage applied to said at least one lens element based on said measured one or more characteristics of at least one of the ion signal and the voltage ramp so as to enhance performance of the mass spectrometer.
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公开(公告)号：US20240177984A1
公开(公告)日：2024-05-30
申请号：US18283378
申请日：2022-03-21
Applicant: DH TECHNOLOGIES DEVELOPMENT PTE. LTD.
Inventor： Bradley Schneider , Leigh Bedford , Aaron Stella , Subhasish Purkayastha
IPC: H01J49/04 , G01N1/38 , G01N27/624 , G01N33/487
CPC classification number: H01J49/0454 , G01N1/38 , G01N27/624 , G01N33/487
Abstract: Methods of detecting at least one analyte in at least one liquid sample are described. The method includes the steps of desalting the liquid sample, acoustically ejecting the desalted sample into an open-port interface, diluting the desalted sample, and transferring the diluted sample to an ionization source, ionizing the diluted sample, and selecting ions of interest by ion mobility
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Patent Agency Ranking
公开(公告)号：US20160334369A1
公开(公告)日：2016-11-17
申请号：US15107487
申请日：2014-11-18
Applicant: DH TECHNOLOGIES DEVELOPMENT PTE LTD.
Inventor： Thomas R. Covey , Bradley Schneider , Erkinjon Nazarov
CPC classification number: G01N27/624 , H01J49/0031
Abstract: A method and apparatus for performing differential mobility spectrometer (DMS) which includes decreasing the amount of time that ions spend inside fringing fields generated by the DMS. The apparatus includes an entrance electrode plate sealingly engaged to the entrance of the DMS, and is electrically separated from the parallel plate electrodes of the DMS, the entrance electrode plate has an aperture for allowing the traversal of ions into the DMS; wherein the cross-sectional area of the aperture is less than the cross-sectional area of the ion path, the ion path being located between the two parallel plate electrodes of the DMS. The entrance electrode plate may also have a focusing potential applied to it for focusing of ions.
Abstract translation: 一种用于执行差分迁移率光谱仪（DMS）的方法和装置，其包括减少离子在由DMS产生的边缘场内消耗的时间量。 该装置包括密封地接合到DMS的入口的入口电极板，并且与DMS的平行板电极电隔离，入口电极板具有用于允许离子穿过DMS的孔; 其中所述孔的横截面面积小于所述离子路径的横截面面积，所述离子路径位于所述DMS的两个平行板电极之间。 入口电极板还可以具有施加到其上用于聚焦离子的聚焦电势。
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公开(公告)号：US20250003929A1
公开(公告)日：2025-01-02
申请号：US18704236
申请日：2022-10-26
Applicant: DH TECHNOLOGIES DEVELOPMENT PTE. LTD.
Inventor： Aaron Stella , Bradley Schneider , Subhasish Purkayastha , Leigh Bedford
Abstract: Disclosed are methods for detecting and quantifying target analytes in a sample by mass analysis that include detecting the presence of ions of the target analyte in the sample and quantifying the amount of the target analyte. The methods can include one or more standards (e.g., internal and/or external standards) that may be labelled (e.g., isotopically labelled).
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公开(公告)号：US20190086363A1
公开(公告)日：2019-03-21
申请号：US16085239
申请日：2017-03-15
Applicant: DH Technologies Development Pte. Ltd.
Inventor： Thomas Covey , Yang Kang , Chang Liu , Bradley Schneider
Abstract: In accordance with various aspects of the present teachings, methods and systems for differential mobility spectrometry are provided herein for simultaneously applying a plurality of SV/CV combinations to subsets of a population of ions generated by one or more ion sources. In various aspects, DMS devices in accordance with the present teachings can provide multiple channels (e.g., 2, 3, 4, 5, 6, or more) for operating in parallel and within which different electrical fields can be generated for filtering sample ions within those channels based on the characteristic mobilities of the ions within each channel. In this manner, devices and methods in accordance with the present teachings can, in various aspects, enable improved duty cycle, increased throughput, decreased sample consumption, increased sensitivity for a plurality of ions of interest, and/or increased resolution.
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公开(公告)号：US11887831B2
公开(公告)日：2024-01-30
申请号：US17312695
申请日：2019-12-12
Applicant: DH Technologies Development Pte. Ltd.
Inventor： Leigh Bedford , Yang Kang , Yves Le Blanc , Bradley Schneider
CPC classification number: H01J49/067 , H01J49/0031 , H01J49/4215
Abstract: In some embodiments, a method for optimizing performance of a mass spectrometer comprises using an ion source to generate ions, collisionally cooling the ions within an ion guide, directing said ions from the ion guide through at least one ion lens to a downstream mass analyzer, ramping a DC voltage applied to the ion lens, performing a mass analysis of the ions within the mass analyzer while the DC voltage applied to the ion lens is ramped, estimating performance of the mass spectrometer by measuring one or more characteristics of at least one of an ion signal and the voltage ramp, and adjusting a DC voltage applied to said at least one lens element based on said measured one or more characteristics of at least one of the ion signal and the voltage ramp so as to enhance performance of the mass spectrometer.
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公开(公告)号：US09835588B2
公开(公告)日：2017-12-05
申请号：US15107487
申请日：2014-11-18
Applicant: DH Technologies Development PTE Ltd.
Inventor： Thomas R. Covey , Bradley Schneider , Erkinjon Nazarov
CPC classification number: G01N27/624 , H01J49/0031
Abstract: A method and apparatus for performing differential mobility spectrometer (DMS) which includes decreasing the amount of time that ions spend inside fringing fields generated by the DMS. The apparatus includes an entrance electrode plate sealingly engaged to the entrance of the DMS, and is electrically separated from the parallel plate electrodes of the DMS, the entrance electrode plate has an aperture for allowing the traversal of ions into the DMS; wherein the cross-sectional area of the aperture is less than the cross-sectional area of the ion path, the ion path being located between the two parallel plate electrodes of the DMS. The entrance electrode plate may also have a focusing potential applied to it for focusing of ions.
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