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    Non-invasive method of diagnosing renal fibrosis
    2.
    发明授权
    Non-invasive method of diagnosing renal fibrosis 有权

    公开(公告)号：US10472679B2

    公开(公告)日：2019-11-12

    申请号：US14400873

    申请日：2013-05-15

    申请人： Cornell University

    发明人： Manikkam Suthanthiran ,  Joseph E. Schwartz ,  Ruchuang Ding ,  Thangamani Muthukumar

    IPC分类号： C12Q1/6883 ,  G16H50/20

    摘要： Measurement of mRNAs in urinary cells offers a noninvasive means of diagnosing fibrosis in kidneys. One aspect of the invention is a method that includes: (a) measuring quantities of vimentin mRNA, NKCC2 mRNA, and E-cadherin mRNA in a test sample of cells obtained from urine; and (b) determining whether the vimentin mRNA quantity is higher, the NKCC2 mRNA quantity is lower, or the E-cadherin mRNA is higher than in healthy urinary cells; and thereby detecting that the sample is a fibrotic kidney sample. Step (a) can also include measuring the quantity of RNA expressed by a housekeeping gene (e.g., 18S rRNA). The quantities of vimentin mRNA, NKCC2 mRNA, and E-cadherin mRNA can be normalized against the quantity of housekeeping gene RNA.

    Method to match organ donors to recipients for transplantation
    3.
    发明授权
    Method to match organ donors to recipients for transplantation 有权

    公开(公告)号：US10720226B2

    公开(公告)日：2020-07-21

    申请号：US15112105

    申请日：2015-01-15

    申请人： Cornell University

    发明人： Fabien Campagne ,  Laurent Mesnard ,  Manikkam Suthanthiran ,  Thangamani Muthukumar

    IPC分类号： G16B30/00 ,  G16B40/00 ,  C12Q1/6883 ,  G16B20/00

    摘要： This invention describes an allogenomics mismatch scoring method that estimates the genomic incompatibility between potential organ donors and a transplant recipient. The allogenomics method addresses immunological concerns and compares genotype information from matched, or potential, donors and recipients. The allogenomics method uses genomic data available before transplantation and predicts kidney graft function for greater than three years after transplantation. The strength of the inverse correlation between pre-transplantation genomic mismatches and transplant organ function increases with the time after transplantation: a low allogenomics mismatch score correlates with better acceptance and function of a donor transplant over time.

    METHOD TO MATCH ORGAN DONORS TO RECIPIENTS FOR TRANSPLANTATION
    4.
    发明申请
    METHOD TO MATCH ORGAN DONORS TO RECIPIENTS FOR TRANSPLANTATION 审中-公开
    将有机体贡献者与运输员接受的方法

    公开(公告)号：US20160328515A1

    公开(公告)日：2016-11-10

    申请号：US15112105

    申请日：2015-01-15

    申请人： CORNELL UNIVERSITY

    发明人： Fabien Campagne ,  Laurent Mesnard ,  Manikkam Suthanthiran ,  Thangamani Muthukumar

    IPC分类号： G06F19/22 ,  C12Q1/68 ,  G06F19/24

    摘要： This invention describes an allogenomics mismatch scoring method that estimates the genomic incompatibility between potential organ donors and a transplant recipient. The allogenomics method addresses immunological concerns and compares genotype information from matched, or potential, donors and recipients. The allogenomics method uses genomic data available before transplantation and predicts kidney graft function for greater than three years after transplantation. The strength of the inverse correlation between pre-transplantation genomic mismatches and transplant organ function increases with the time after transplantation: a low allogenomics mismatch score correlates with better acceptance and function of a donor transplant over time.

    摘要翻译： 本发明描述了估计潜在器官供体和移植受体之间的基因组不相容性的同种异体错配评估方法。 同种异体方法解决免疫学问题，并比较来自匹配或潜在的捐助者和受体的基因型信息。 同种异体方法使用移植前可用的基因组数据，并预测移植后3年以上的肾移植功能。 移植前基因组错配与移植器官功能之间的逆相关强度随着移植后的时间而增加：低同种异体错配评分与供体移植随时间的更好的接受和功能相关。

    NON-INVASIVE METHOD OF DIAGNOSING RENAL FIBROSIS
    5.
    发明申请
    NON-INVASIVE METHOD OF DIAGNOSING RENAL FIBROSIS 审中-公开
    非侵入性方法诊断肾脏纤维化

    公开(公告)号：US20150240305A1

    公开(公告)日：2015-08-27

    申请号：US14400873

    申请日：2013-05-15

    申请人： Cornell University

    发明人： Manikkam Suthanthiran ,  Joseph E. Schwartz ,  Ruchuang Ding ,  Thangamani Muthukumar

    IPC分类号： C12Q1/68 ,  G06F19/00

    摘要： Measurement of mRNAs in urinary cells offers a noninvasive means of diagnosing fibrosis in kidneys. One aspect of the invention is a method that includes: (a) measuring quantities of vimentin mRNA, NKCC2 mRNA, and E-cadherin mRNA in a test sample of cells obtained from urine; and (b) determining whether the vimentin mRNA quantity is higher, the NKCC2 mRNA quantity is lower, or the E-cadherin mRNA is higher than in healthy urinary cells; and thereby detecting that the sample is a fibrotic kidney sample. Step (a) can also include measuring the quantity of RNA expressed by a housekeeping gene (e.g., 18S rRNA). The quantities of vimentin mRNA, NKCC2 mRNA, and E-cadherin mRNA can be normalized against the quantity of housekeeping gene RNA.

    摘要翻译： 测量尿细胞中的mRNA提供了诊断肾脏纤维化的非侵入性手段。 本发明的一个方面是一种方法，其包括：（a）在从尿获得的细胞的测试样品中测量波形蛋白mRNA，NKCC2 mRNA和E-钙粘蛋白mRNA的量; 和（b）确定波形蛋白mRNA的量是否较高，NKCC2 mRNA的含量较低，或E-钙粘蛋白的mRNA高于健康的尿细胞; 从而检测样品是纤维化肾脏样品。 步骤（a）还可以包括测量由持家基因（例如18S rRNA）表达的RNA的量。 波形蛋白mRNA，NKCC2 mRNA和E-钙粘蛋白mRNA的量可以根据持家基因RNA的数量进行标准化。