公开(公告)号：US10720226B2

公开(公告)日：2020-07-21

申请号：US15112105

申请日：2015-01-15

申请人： Cornell University

发明人： Fabien Campagne ,  Laurent Mesnard ,  Manikkam Suthanthiran ,  Thangamani Muthukumar

IPC分类号： G16B30/00 ,  G16B40/00 ,  C12Q1/6883 ,  G16B20/00

摘要： This invention describes an allogenomics mismatch scoring method that estimates the genomic incompatibility between potential organ donors and a transplant recipient. The allogenomics method addresses immunological concerns and compares genotype information from matched, or potential, donors and recipients. The allogenomics method uses genomic data available before transplantation and predicts kidney graft function for greater than three years after transplantation. The strength of the inverse correlation between pre-transplantation genomic mismatches and transplant organ function increases with the time after transplantation: a low allogenomics mismatch score correlates with better acceptance and function of a donor transplant over time.

公开(公告)号：US20160328515A1

公开(公告)日：2016-11-10

申请号：US15112105

申请日：2015-01-15

申请人： CORNELL UNIVERSITY

发明人： Fabien Campagne ,  Laurent Mesnard ,  Manikkam Suthanthiran ,  Thangamani Muthukumar

IPC分类号： G06F19/22 ,  C12Q1/68 ,  G06F19/24

摘要： This invention describes an allogenomics mismatch scoring method that estimates the genomic incompatibility between potential organ donors and a transplant recipient. The allogenomics method addresses immunological concerns and compares genotype information from matched, or potential, donors and recipients. The allogenomics method uses genomic data available before transplantation and predicts kidney graft function for greater than three years after transplantation. The strength of the inverse correlation between pre-transplantation genomic mismatches and transplant organ function increases with the time after transplantation: a low allogenomics mismatch score correlates with better acceptance and function of a donor transplant over time.

摘要翻译： 本发明描述了估计潜在器官供体和移植受体之间的基因组不相容性的同种异体错配评估方法。 同种异体方法解决免疫学问题，并比较来自匹配或潜在的捐助者和受体的基因型信息。 同种异体方法使用移植前可用的基因组数据，并预测移植后3年以上的肾移植功能。 移植前基因组错配与移植器官功能之间的逆相关强度随着移植后的时间而增加：低同种异体错配评分与供体移植随时间的更好的接受和功能相关。