公开(公告)号：US11413334B2

公开(公告)日：2022-08-16

申请号：US16924681

申请日：2020-07-09

Applicant: CONTRAFECT CORPORATION

Inventor： Raymond Schuch ,  Simon Hoffenberg ,  Michael Wittekind

IPC: A61K38/47 ,  A61K38/12 ,  A61K45/06 ,  A61K9/00 ,  A61K31/7036 ,  A61K38/46 ,  A61K38/16 ,  A61P31/04 ,  C12N9/36

Abstract: The present disclosure provides methods and compositions useful for the prophylactic and therapeutic amelioration and treatment of infections caused by Gram-negative bacteria, including Pseudomonas aeruginosa. The disclosure further provides compositions and methods of incorporating and utilizing lysin polypeptides of the present disclosure for augmenting the efficacy of antibiotics generally suitable for the treatment of Gram-negative bacterial infection.

公开(公告)号：US10744189B2

公开(公告)日：2020-08-18

申请号：US15760283

申请日：2016-09-16

Applicant: ContraFect Corporation

Inventor： Raymond Schuch ,  Simon Hoffenberg ,  Michael Wittekind

IPC: A61K38/47 ,  A61K38/12 ,  A61K45/06 ,  A61K9/00 ,  A61K31/7036 ,  A61K38/46 ,  A61K38/16 ,  A61P31/04 ,  C12N9/36

Abstract: The present disclosure provides methods and compositions useful for the prophylactic and therapeutic amelioration and treatment of infections caused by Gram-negative bacteria, including Pseudomonas aeruginosa. The disclosure further provides compositions and methods of incorporating and utilizing lysin polypeptides of the present disclosure for augmenting the efficacy of antibiotics generally suitable for the treatment of Gram-negative bacterial infection.