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    BIOCATALYSTS AND METHODS FOR SYNTHESIZING DERIVATIVES OF TRYPTAMINE AND TRYPTAMINE ANALOGS
    2.
    发明申请
    BIOCATALYSTS AND METHODS FOR SYNTHESIZING DERIVATIVES OF TRYPTAMINE AND TRYPTAMINE ANALOGS 有权
    生物合成与合成木霉素和木霉素类似物衍生物的方法

    公开(公告)号：US20150072383A1

    公开(公告)日：2015-03-12

    申请号：US14386082

    申请日：2013-03-22

    Applicant: Codexis, Inc.

    Inventor： Jovana Nazor ,  Derek Smith ,  Michael Crowe ,  Shiwei Song ,  Steven J. Collier

    IPC: C12N9/10 ,  C12P17/10

    CPC classification number: C12N9/1096 ,  C12P17/10 ,  C12Y206/01 ,  C12Y206/01018 ,  Y02P20/52

    Abstract: The present disclosure provides engineered transaminase polypeptides for the production of amines, polynucleotides encoding the engineered transaminases, host cells capable of expressing the engineered transaminases, and methods of using the engineered transaminases to prepare compounds useful in the production of active pharmaceutical agents. The present disclosure provides engineered polypeptides having transaminase activity, polynucleotides encoding the polypeptides, methods of the making the polypeptides, and methods of using the polypeptides for the biocatalytic conversion of ketone substrates to amine products. The present enzymes have been engineered to have one or more residue differences as compared to the amino acid sequence of the naturally occurring transaminase of Vibrio fluvialis. In particular, the transaminases of the present disclosure have been engineered for efficient formation of chiral tryptamine derivatives from its corresponding prochiral ketone substrates.

    Abstract translation: 本公开提供了用于制备胺的工程化转氨酶多肽，编码工程改造氨基酸的多核苷酸，能够表达工程化转氨酶的宿主细胞以及使用工程改造的转氨酶来制备用于生产活性药剂的化合物的方法。 本公开提供了具有转氨酶活性的工程改造的多肽，编码多肽的多核苷酸，制备多肽的方法，以及使用多肽将酮底物生物催化转化成胺产物的方法。 与本发明的弧菌弧菌的天然存在的转氨酶的氨基酸序列相比，本发明的酶已被改造成具有一个或多个残基差异。 特别地，本公开的转氨酶已被设计用于从其相应的前手性酮底物有效形成手性色胺衍生物。

    Biocatalysts and methods for synthesizing derivatives of tryptamine and tryptamine analogs
    4.
    发明授权
    Biocatalysts and methods for synthesizing derivatives of tryptamine and tryptamine analogs 有权
    生物催化剂和合成色胺和色胺类似物衍生物的方法

    公开(公告)号：US09139821B2

    公开(公告)日：2015-09-22

    申请号：US14386082

    申请日：2013-03-22

    Applicant: Codexis, Inc.

    Inventor： Jovana Nazor ,  Derek Smith ,  Michael Crowe ,  Shiwei Song ,  Steven J. Collier

    IPC: C12P17/10 ,  C12N9/10

    CPC classification number: C12N9/1096 ,  C12P17/10 ,  C12Y206/01 ,  C12Y206/01018 ,  Y02P20/52

    Abstract: The present disclosure provides engineered transaminase polypeptides for the production of amines, polynucleotides encoding the engineered transaminases, host cells capable of expressing the engineered transaminases, and methods of using the engineered transaminases to prepare compounds useful in the production of active pharmaceutical agents. The present disclosure provides engineered polypeptides having transaminase activity, polynucleotides encoding the polypeptides, methods of the making the polypeptides, and methods of using the polypeptides for the biocatalytic conversion of ketone substrates to amine products. The present enzymes have been engineered to have one or more residue differences as compared to the amino acid sequence of the naturally occurring transaminase of Vibrio fluvialis. In particular, the transaminases of the present disclosure have been engineered for efficient formation of chiral tryptamine derivatives from its corresponding prochiral ketone substrates.

    Abstract translation: 本公开提供了用于制备胺的工程化转氨酶多肽，编码工程改造氨基酸的多核苷酸，能够表达工程化转氨酶的宿主细胞以及使用工程改造的转氨酶来制备用于生产活性药剂的化合物的方法。 本公开提供了具有转氨酶活性的工程改造的多肽，编码多肽的多核苷酸，制备多肽的方法，以及使用多肽将酮底物生物催化转化成胺产物的方法。 与本发明的弧菌弧菌的天然存在的转氨酶的氨基酸序列相比，本发明的酶已被改造成具有一个或多个残基差异。 特别地，本公开的转氨酶已被设计用于从其相应的前手性酮底物有效形成手性色胺衍生物。

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