公开(公告)号：US12195531B2

公开(公告)日：2025-01-14

申请号：US16568702

申请日：2019-09-12

Applicant: CODE BIOTHERAPEUTICS, INC. ,  Lankenau Institute of Medical Research

Inventor： Robert C. Getts ,  James Kadushin ,  Mindy George-Weinstein ,  Jacquelyn Gerhart ,  Emanuela Dylgjeri ,  Kelly Rhodes

IPC: C07K16/28 ,  A61K9/51 ,  A61K31/704 ,  A61K31/713 ,  A61K47/54 ,  A61K47/62 ,  A61K47/68 ,  A61K47/69

Abstract: Compositions and methods for targeted delivery of active agents to cells are provided. The compositions comprise a wholly or partially double-stranded synthetic DNA carrier, and an active agent intercalated in double-stranded portions of the DNA carrier. The DNA carrier may also be linked to a targeting agent. The compositions are useful for delivering an active agent into a targeted cell type, for example a cytotoxic agent.

公开(公告)号：US11802151B2

公开(公告)日：2023-10-31

申请号：US17088256

申请日：2020-11-03

Applicant: Code Biotherapeutics, Inc.

Inventor： Robert Getts ,  Jessica Bowers ,  Mindy Ellen George-Weinstein ,  Jacquelyn Gerhart

IPC: C07K16/28 ,  G01N33/53 ,  C07K16/18 ,  A61K47/68 ,  G01N33/68 ,  A61K31/713 ,  G01N33/574 ,  A61K39/00

CPC classification number: C07K16/28 ,  A61K31/713 ,  A61K47/6803 ,  A61K47/6843 ,  C07K16/18 ,  G01N33/574 ,  G01N33/68 ,  A61K39/001102 ,  C07K2317/24

Abstract: The present disclosure provides an antibody that binds human Adhesion G Protein-Coupled Receptor B1 (BAI1) protein, compositions comprising the same, and use thereof in methods of detection, methods of diagnosis, and methods of treatment.