公开(公告)号：US20180327865A1

公开(公告)日：2018-11-15

申请号：US15590120

申请日：2017-05-09

Applicant: City University of Hong Kong

Inventor： Zicheng Zhao ,  Bowen Tan ,  Shuai Cheng Li

IPC: C12Q1/68 ,  G06F19/14 ,  G06F19/24

CPC classification number: C12Q1/6888 ,  C12Q2600/156 ,  G06F19/14 ,  G06F19/24

Abstract: A next generation sequencing (NGS) based method includes applying, for one or more genetic loci, respective NGS data for genotype of a first subject, genotype of a second subject, and genotype of an alleged offspring of the first and second subjects to a statistical model calculating a value representing a likelihood the offspring is a true offspring of the first and second subjects. The NGS data includes genotype and sequencing read of the first tested subject; genotype and sequencing read of the second tested subject; and genotype and sequencing read of the alleged offspring. The statistical model utilizes a probability of the genotype of the first tested subject in a subject population; a probability of the genotype of the second tested subject in a subject population; and a probability of the genotype of the alleged offspring in a subject population.