公开(公告)号：US20180327865A1

公开(公告)日：2018-11-15

申请号：US15590120

申请日：2017-05-09

Applicant: City University of Hong Kong

Inventor： Zicheng Zhao ,  Bowen Tan ,  Shuai Cheng Li

IPC: C12Q1/68 ,  G06F19/14 ,  G06F19/24

CPC classification number: C12Q1/6888 ,  C12Q2600/156 ,  G06F19/14 ,  G06F19/24

Abstract: A next generation sequencing (NGS) based method includes applying, for one or more genetic loci, respective NGS data for genotype of a first subject, genotype of a second subject, and genotype of an alleged offspring of the first and second subjects to a statistical model calculating a value representing a likelihood the offspring is a true offspring of the first and second subjects. The NGS data includes genotype and sequencing read of the first tested subject; genotype and sequencing read of the second tested subject; and genotype and sequencing read of the alleged offspring. The statistical model utilizes a probability of the genotype of the first tested subject in a subject population; a probability of the genotype of the second tested subject in a subject population; and a probability of the genotype of the alleged offspring in a subject population.

公开(公告)号：US11451522B2

公开(公告)日：2022-09-20

申请号：US16002136

申请日：2018-06-07

Applicant: City University of Hong Kong

Inventor： Shuai Cheng Li ,  Wei Dong

IPC: H04L29/06 ,  H04L9/40 ,  G16H10/60 ,  G16B50/00

Abstract: A system and method for a computer system for the secure storage, transmittance and access of genetic data includes a coordinator server including a coordinator program arranged to update secure access information, the coordinator server being in communication with a genetic data sequencing server, a genetic data analysing server, and a genetic data storage server, whereby the coordinator server communicates the secure access information in a manner to allow the genetic data storage server to act as a proxy server between the genetic data sequencing server and the genetic data analysing server.