公开(公告)号：US11932697B2

公开(公告)日：2024-03-19

申请号：US17477983

申请日：2021-09-17

申请人： Chugai Seiyaku Kabushiki Kaisha

发明人： Tomoyuki Igawa ,  Hiroyuki Ishikawa ,  Naoka Hironiwa

IPC分类号： C40B40/10 ,  C07K16/28 ,  C07K16/30 ,  G01N33/68

CPC分类号： C07K16/2866 ,  C07K16/2809 ,  C07K16/303 ,  C40B40/10 ,  G01N33/6854 ,  C07K2317/22 ,  C07K2317/31 ,  C07K2317/569 ,  C07K2319/50

摘要： The present invention relates to a polypeptide comprising an antigen binding domain and a carrying moiety having an inhibiting domain that inhibits the antigen binding activity of the antigen binding domain, and having a longer half-life than that of the antigen binding domain existing alone, methods for producing and screening for the polypeptide, a pharmaceutical composition comprising the polypeptide, methods for producing and screening for a single-domain antibody whose antigen binding activity is inhibited by associating with particular VL, VH or VHH, and a fusion polypeptide library including a single-domain antibody whose antigen binding activity is inhibited by associating with particular VL, VH or VHH.

公开(公告)号：US12060654B2

公开(公告)日：2024-08-13

申请号：US16463218

申请日：2017-11-28

申请人： CHUGAI SEIYAKU KABUSHIKI KAISHA

发明人： Tomoyuki Igawa ,  Hiroyuki Ishikawa

IPC分类号： C40B40/10 ,  C07K16/24 ,  C07K16/28 ,  A61K39/00

CPC分类号： C40B40/10 ,  C07K16/244 ,  C07K16/2818 ,  C07K16/2866 ,  A61K2039/505

摘要： The present invention relates to a ligand binding molecule whose ligand binding activity is attenuated by the cleavage of a cleavage site and a method for producing the same, a complex formed by the ligand binding molecule and a ligand, a fusion protein comprising the ligand binding molecule and a ligand, and a pharmaceutical composition comprising the ligand binding molecule or a fusion protein of the ligand binding molecule and a ligand.

公开(公告)号：US12030955B2

公开(公告)日：2024-07-09

申请号：US16767085

申请日：2018-11-28

申请人： Chugai Seiyaku Kabushiki Kaisha

发明人： Tomoyuki Igawa ,  Hiroyuki Ishikawa ,  Naoka Hironiwa ,  Tatsuya Kawa

IPC分类号： C07K16/28 ,  C07K16/30 ,  C07K16/32

CPC分类号： C07K16/303 ,  C07K16/2809 ,  C07K16/2866 ,  C07K16/32 ,  C07K2317/31 ,  C07K2317/515 ,  C07K2317/52 ,  C07K2317/569

摘要： The present invention relates to polypeptides containing an antigen-binding domain and a carrying moiety having an inhibiting domain that inhibits the antigen-binding activity of the antigen-binding domain, and having a longer half-life than that of the antigen-binding domain existing alone; methods for producing and screening for the polypeptides; pharmaceutical compositions containing the polypeptide; methods for producing and screening for a single-domain antibody whose antigen-binding activity is inhibited by its association with particular VL, VH or VHH; and fusion polypeptide libraries including a single-domain antibody whose antigen-binding activity is inhibited by its association with particular VL, VH or VHH.

公开(公告)号：US11168139B2

公开(公告)日：2021-11-09

申请号：US16463222

申请日：2017-11-28

申请人： CHUGAI SEIYAKU KABUSHIKI KAISHA

发明人： Tomoyuki Igawa ,  Hiroyuki Ishikawa ,  Naoka Hironiwa

IPC分类号： C40B40/10 ,  C07K16/28 ,  C07K16/30 ,  G01N33/68

摘要： The present invention relates to a polypeptide comprising an antigen binding domain and a carrying moiety having an inhibiting domain that inhibits the antigen binding activity of the antigen binding domain, and having a longer half-life than that of the antigen binding domain existing alone, methods for producing and screening for the polypeptide, a pharmaceutical composition comprising the polypeptide, methods for producing and screening for a single-domain antibody whose antigen binding activity is inhibited by associating with particular VL, VH or VHH, and a fusion polypeptide library including a single-domain antibody whose antigen binding activity is inhibited by associating with particular VL, VH or VHH.