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公开(公告)号：US09783544B2
公开(公告)日：2017-10-10
申请号：US14836172
申请日：2015-08-26
申请人： ChemoCentryx, Inc.
发明人： Junfa Fan , Antoni Krasinski , Christopher W. Lange , Rebecca M. Lui , Jeffrey P. McMahon , Jay P. Powers , Yibin Zeng , Penglie Zhang
IPC分类号： A61K51/04 , C07D487/04 , G01N33/574
CPC分类号： C07D487/04 , A61K51/0459 , G01N33/57492 , G01N2333/7158
摘要： Compounds having formula I, or pharmaceutically acceptable salts, hydrates or N-oxides thereof are provided and are useful for binding to CXCR7, and treating diseases that are dependent, at least in part, on CXCR7 activity. Accordingly, the present invention provides in further aspects, compositions containing one or more of the above-noted compounds in admixture with a pharmaceutically acceptable excipient.
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公开(公告)号：US20160317545A1
公开(公告)日：2016-11-03
申请号：US15207315
申请日：2016-07-11
申请人： CHEMOCENTRYX, INC.
发明人： Trevor T. Charvat , Junfa Fan , Christopher W. Lange , Manmohan Reddy Leleti , Yandong Li , Venkat Reddy Mali , Jeffrey P. McMahon , Jay Powers , Sreenivas Punna , Ju Yang
IPC分类号： A61K31/5377 , A61K31/495 , A61K31/454 , A61K31/496 , A61K31/4545 , A61K31/451
CPC分类号： C07D413/06 , A61K31/451 , A61K31/454 , A61K31/4545 , A61K31/495 , A61K31/496 , A61K31/5377 , C07D207/16 , C07D211/26 , C07D211/34 , C07D211/56 , C07D211/62 , C07D211/70 , C07D241/04 , C07D295/135 , C07D401/04 , C07D401/06 , C07D403/06 , C07D405/06 , C07D417/04
摘要： Aniline compounds are provided which bind to CCR(4) and are useful for the treatment of diseases such as allergic diseases, autoimmune diseases, graft rejection and cancer.
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公开(公告)号：US20140154179A1
公开(公告)日：2014-06-05
申请号：US14091641
申请日：2013-11-27
申请人： ChemoCentryx, Inc.
发明人： Junfa Fan , Antoni Krasinski , Christopher W. Lange , Rebecca M. Lui , Jeffrey P. McMahon , Jay P. Powers , Yibin Zeng , Penglie Zhang
IPC分类号： C07D487/04 , A61K49/10 , A61K51/04
CPC分类号： C07D487/04 , A61K51/0459 , G01N33/57492 , G01N2333/7158
摘要： Compounds having formula I, or pharmaceutically acceptable salts, hydrates or N-oxides thereof are provided and are useful for binding to CXCR7, and treating diseases that are dependent, at least in part, on CXCR7 activity. Accordingly, the present invention provides in further aspects, compositions containing one or more of the above-noted compounds in admixture with a pharmaceutically acceptable excipient.
摘要翻译： 提供具有式I化合物或其药学上可接受的盐，水合物或N-氧化物，并且可用于结合CXCR7，并且治疗至少部分依赖于CXCR7活性的疾病。 因此，本发明还提供含有一种或多种上述化合物与药学上可接受的赋形剂混合的组合物。
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公开(公告)号：US11059825B2
公开(公告)日：2021-07-13
申请号：US16379599
申请日：2019-04-09
申请人： CHEMOCENTRYX, INC.
发明人： Junfa Fan , Antoni Krasinski , Christopher W. Lange , Rebecca M. Lui , Jeffrey P. McMahon , Jay P. Powers , Yibin Zeng , Penglie Zhang
IPC分类号： C07D487/04 , A61K51/04 , G01N33/574
摘要： Compounds having formula I, or pharmaceutically acceptable salts, hydrates or N-oxides thereof are provided and are useful for binding to CXCR7, and treating diseases that are dependent, at least in part, on CXCR7 activity. Accordingly, the present invention provides in further aspects, compositions containing one or more of the above-noted compounds in admixture with a pharmaceutically acceptable excipient.
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公开(公告)号：US10464934B2
公开(公告)日：2019-11-05
申请号：US15692811
申请日：2017-08-31
申请人： CHEMOCENTRYX, INC.
发明人： Junfa Fan , Jaroslaw Kalisiak , Rebecca M. Lui , Venkat Reddy Mali , Jeffrey P. McMahon , Jay P. Powers , Hiroko Tanaka , Yibin Zeng , Penglie Zhang
IPC分类号： C07D309/04 , C07D471/04 , A61K31/4545 , C07D405/04 , A61K31/453 , A61K31/496 , C07D413/14 , A61K31/536 , C07D405/14 , A61K31/4725 , A61P35/00 , A61P37/00 , A61K45/06
摘要： Compounds are provided that are modulators of the CCR2 receptor. The compounds have the general formula (I): and are useful in pharmaceutical compositions, methods for the treatment of diseases and disorders involving the pathologic activation of CCR2 receptors.
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公开(公告)号：US09783540B2
公开(公告)日：2017-10-10
申请号：US15158713
申请日：2016-05-19
申请人： CHEMOCENTRYX, INC.
发明人： Junfa Fan , Jaroslaw Kalisiak , Rebecca M. Lui , Venkat Reddy Mali , Jeffrey P. McMahon , Jay P. Powers , Hiroko Tanaka , Yibin Zeng , Penglie Zhang
IPC分类号： A61K31/351 , C07D309/04 , C07D471/04 , A61K31/4545 , C07D405/04 , A61K31/453 , A61K31/496 , C07D413/14 , A61K31/536 , C07D405/14 , A61K31/4725
CPC分类号： C07D471/04 , A61K31/453 , A61K31/4545 , A61K31/4725 , A61K31/496 , A61K31/536 , C07D405/04 , C07D405/14 , C07D413/14
摘要： Compounds are provided that are modulators of the CCR2 receptor. The compounds have the general formula (I): and are useful in pharmaceutical compositions, methods for the treatment of diseases and disorders involving the pathologic activtation of CCR2 receptors.
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公开(公告)号：US11142521B2
公开(公告)日：2021-10-12
申请号：US16526338
申请日：2019-07-30
申请人： CHEMOCENTRYX, INC.
发明人： Trevor T. Charvat , Junfa Fan , Christopher W. Lange , Manmohan Reddy Leleti , Yandong Li , Venkat Reddy Mali , Jeffrey P. McMahon , Jay Powers , Sreenivas Punna , Ju Yang
IPC分类号： C07D413/06 , C07D401/04 , C07D403/06 , C07D405/06 , C07D417/04 , C07D211/56 , C07D295/135 , C07D211/62 , C07D401/06 , C07D211/26 , C07D211/70 , C07D241/04 , C07D207/16 , C07D211/34 , A61K31/451 , A61K31/454 , A61K31/4545 , A61K31/495 , A61K31/496 , A61K31/5377
摘要： Aniline compounds are provided which bind to CCR(4) and are useful for the treatment of diseases such as allergic diseases, autoimmune diseases, graft rejection and cancer.
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公开(公告)号：US09567323B2
公开(公告)日：2017-02-14
申请号：US14452341
申请日：2014-08-05
申请人： ChemoCentryx, Inc.
发明人： Trevor T. Charvat , Junfa Fan , Christopher W. Lange , Manmohan Reddy Leleti , Yandong Li , Venkat Reddy Mali , Jeffrey P. McMahon , Jay Powers , Sreenivas Punna , Ju Yang
IPC分类号： A01N43/00 , A61K31/55 , C07D413/06 , C07D401/04 , C07D401/06 , C07D403/06 , C07D405/06 , C07D417/04 , C07D211/56 , C07D295/135 , C07D211/62 , C07D211/26 , C07D211/70 , C07D241/04 , C07D207/16 , C07D211/34
CPC分类号： C07D413/06 , A61K31/451 , A61K31/454 , A61K31/4545 , A61K31/495 , A61K31/496 , A61K31/5377 , C07D207/16 , C07D211/26 , C07D211/34 , C07D211/56 , C07D211/62 , C07D211/70 , C07D241/04 , C07D295/135 , C07D401/04 , C07D401/06 , C07D403/06 , C07D405/06 , C07D417/04
摘要： Aniline compounds are provided which bind to CCR(4) and are useful for the treatment of diseases such as allergic diseases, autoimmune diseases, graft rejection and cancer.
摘要翻译： 提供了与CCR（4）结合的苯胺化合物，可用于治疗过敏性疾病，自身免疫性疾病，移植物排斥反应和癌症等疾病。
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公开(公告)号：US20160340356A1
公开(公告)日：2016-11-24
申请号：US15158713
申请日：2016-05-19
申请人： CHEMOCENTRYX, INC.
发明人： Junfa Fan , Jaroslaw Kalisiak , Rebecca M. Lui , Venkat Reddy Mali , Jeffrey P. McMahon , Jay P. Powers , Hiroko Tanaka , Yibin Zeng , Penglie Zhang
IPC分类号： C07D471/04 , C07D405/04 , A61K31/453 , A61K31/4725 , C07D413/14 , A61K31/536 , C07D405/14 , A61K31/4545 , A61K31/496
CPC分类号： C07D471/04 , A61K31/453 , A61K31/4545 , A61K31/4725 , A61K31/496 , A61K31/536 , C07D405/04 , C07D405/14 , C07D413/14
摘要： Compounds are provided that are modulators of the CCR2 receptor. The compounds have the general formula (I): and are useful in pharmaceutical compositions, methods for the treatment of diseases and disorders involving the pathologic activtation of CCR2 receptors.
摘要翻译： 并且可用于药物组合物，用于治疗涉及CCR2受体的病理性激活的疾病和病症的方法。
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公开(公告)号：US20160145259A1
公开(公告)日：2016-05-26
申请号：US14836172
申请日：2015-08-26
申请人： ChemoCentryx, Inc.
发明人： Junfa FAN , Antoni Krasinski , Christopher W. Lange , Rebecca M. Lui , Jeffrey P. McMahon , Jay P. Powers , Yibin Zeng , Penglie Zhang
IPC分类号： C07D487/04 , G01N33/574 , A61K51/04
CPC分类号： C07D487/04 , A61K51/0459 , G01N33/57492 , G01N2333/7158
摘要： Compounds having formula I, or pharmaceutically acceptable salts, hydrates or N-oxides thereof are provided and are useful for binding to CXCR7, and treating diseases that are dependent, at least in part, on CXCR7 activity. Accordingly, the present invention provides in further aspects, compositions containing one or more of the above-noted compounds in admixture with a pharmaceutically acceptable excipient.
摘要翻译： 提供具有式I化合物或其药学上可接受的盐，水合物或N-氧化物，并且可用于结合CXCR7，并且治疗至少部分依赖于CXCR7活性的疾病。 因此，本发明还提供含有一种或多种上述化合物与药学上可接受的赋形剂混合的组合物。
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