公开(公告)号：US10906020B2

公开(公告)日：2021-02-02

申请号：US14871287

申请日：2015-09-30

Applicant: CARDINAL HEALTH 414, LLC.

Inventor： Dennis Eshima ,  Mehmet Husnu ,  James Stone ,  Derrick Alcaide ,  Joseph E. Zambanini ,  Thomas A. Klausing ,  Chad E. Bouton ,  Henry Padgett ,  Brian C. Kelley ,  Scott N. Danhof ,  David A. Holley ,  Jeffrey T. Stroup ,  James B. Gleeson ,  Eric Hassenpflug ,  James A. Prescott ,  Herman Benecke ,  Daniel B. Garbark

IPC: B01J19/00 ,  G21G1/10 ,  A61K51/04 ,  B65B3/00 ,  B65B1/00 ,  G21G1/00 ,  A61J3/00

Abstract: Systems, methods, and devices for generating radionuclides for use in production of radiopharmaceuticals; synthesizing the radionuclides generated and removing any unwanted products; measuring the quantity and activity level of the synthesized radionuclides; distributively delivering the radionuclides in appropriate quantities to modular cassette synthesis units in a modular cassette subsystem for contemporaneous/parallel production of radiopharmaceutical output and that allow reuse and/or quick, safe, and disposable replacement of portions of the subsystem; delivering non-radionuclide components to the modular cassette synthesis units as part of production of radiopharmaceutical output; measuring the quantity and activity level of each stream of radiopharmaceutical output; purifying the radiopharmaceutical output; dispensing individual doses in sterile vial(s); automatically producing labeling and dose related information; performing automated quality control on extracted samples of produced radiopharmaceutical output; and providing software and hardware controls for overall and sub-portion operation for optional remote data collection, communication, and/or control.

公开(公告)号：US11904289B2

公开(公告)日：2024-02-20

申请号：US17131420

申请日：2020-12-22

Applicant: Cardinal Health 414, LLC

Inventor： Dennis Eshima ,  Mehmet Husnu ,  James Stone ,  Derrick Alcaide ,  Joseph E. Zambanini ,  Thomas A. Klausing ,  Chad E. Bouton ,  Henry Padgett ,  Brian C. Kelley ,  Scott N. Danhof ,  David A. Holley ,  Jeffrey T. Stroup ,  James B. Gleeson ,  Eric Hassenpflug ,  James A. Prescott ,  Herman Benecke ,  Daniel B. Garbark

IPC: B01J19/00 ,  G21G1/10 ,  A61K51/04 ,  B65B3/00 ,  B65B1/00 ,  G21G1/00 ,  A61J3/00

CPC classification number: B01J19/0006 ,  A61K51/0491 ,  B01J19/004 ,  B65B1/00 ,  B65B3/003 ,  G21G1/10 ,  A61J3/002 ,  B01J19/0046 ,  B01J2219/00049 ,  B01J2219/0072 ,  B01J2219/00351 ,  B01J2219/00355 ,  B01J2219/00585 ,  B01J2219/00693 ,  B01J2219/00702 ,  B01J2219/00722 ,  B01J2219/00759 ,  G21G2001/0015

Abstract: Systems, methods, and devices for generating radionuclides for use in production of radiopharmaceuticals; synthesizing the radionuclides generated and removing any unwanted products; measuring the quantity and activity level of the synthesized radionuclides; distributively delivering the radionuclides in appropriate quantities to modular cassette synthesis units in a modular cassette subsystem for contemporaneous/parallel production of radiopharmaceutical output and that allow reuse and/or quick, safe, and disposable replacement of portions of the subsystem; delivering non-radionuclide components to the modular cassette synthesis units as part of production of radiopharmaceutical output; measuring the quantity and activity level of each stream of radiopharmaceutical output; purifying the radiopharmaceutical output; dispensing individual doses in sterile vial(s); automatically producing labeling and dose related information; performing automated quality control on extracted samples of produced radiopharmaceutical output; and providing software and hardware controls for overall and sub-portion operation for optional remote data collection, communication, and/or control.