公开(公告)号：US20240299900A1

公开(公告)日：2024-09-12

申请号：US18408350

申请日：2024-01-09

Applicant: Cardinal Health 414, LLC

Inventor： Dennis ESHIMA ,  Mehmet HUSNU ,  James STONE ,  Derrick ALCAIDE ,  Joseph E. ZAMBANINI ,  Thomas A. KLAUSING ,  Chad E. BOUTON ,  Henry PADGETT ,  Brian C. KELLEY ,  Scott N. DANHOF ,  David A. HOLLEY ,  Jeffrey T. STROUP ,  James B. GLEESON ,  Eric HASSENPFLUG ,  James A. PRESCOTT ,  Herman BENECKE ,  Daniel B. GARBARK

IPC: B01J19/00 ,  A61J3/00 ,  A61K51/04 ,  B65B1/00 ,  B65B3/00 ,  G21G1/00 ,  G21G1/10

CPC classification number: B01J19/0006 ,  A61K51/0491 ,  B01J19/004 ,  B65B1/00 ,  B65B3/003 ,  G21G1/10 ,  A61J3/002 ,  B01J19/0046 ,  B01J2219/00049 ,  B01J2219/00351 ,  B01J2219/00355 ,  B01J2219/00585 ,  B01J2219/00693 ,  B01J2219/00702 ,  B01J2219/0072 ,  B01J2219/00722 ,  B01J2219/00759 ,  G21G2001/0015

Abstract: Systems, methods, and devices for generating radionuclides for use in production of radiopharmaceuticals; synthesizing the radionuclides generated and removing any unwanted products; measuring the quantity and activity level of the synthesized radionuclides; distributively delivering the radionuclides in appropriate quantities to modular cassette synthesis units in a modular cassette subsystem for contemporaneous/parallel production of radiopharmaceutical output and that allow reuse and/or quick, safe, and disposable replacement of portions of the subsystem; delivering non-radionuclide components to the modular cassette synthesis units as part of production of radiopharmaceutical output; measuring the quantity and activity level of each stream of radiopharmaceutical output; purifying the radiopharmaceutical output; dispensing individual doses in sterile vial(s); automatically producing labeling and dose related information; performing automated quality control on extracted samples of produced radiopharmaceutical output; and providing software and hardware controls for overall and sub-portion operation for optional remote data collection, communication, and/or control.

公开(公告)号：US20210187467A1

公开(公告)日：2021-06-24

申请号：US17131420

申请日：2020-12-22

Applicant: Cardinal Health 414, LLC

Inventor： Dennis ESHIMA ,  Mehmet HUSNU ,  James STONE ,  Derrick ALCAIDE ,  Joseph E. ZAMBANINI ,  Thomas A. KLAUSING ,  Chad E. BOUTON ,  Henry PADGETT ,  Brian C. KELLEY ,  Scott N. DANHOF ,  David A. HOLLEY ,  Jeffrey T. STROUP ,  James B. GLEESON ,  Eric HASSENPFLUG ,  James A. PRESCOTT ,  Herman BENECKE ,  Daniel B. GARBARK

IPC: B01J19/00 ,  G21G1/10 ,  A61K51/04 ,  B65B3/00 ,  B65B1/00

Abstract: Systems, methods, and devices for generating radionuclides for use in production of radiopharmaceuticals; synthesizing the radionuclides generated and removing any unwanted products; measuring the quantity and activity level of the synthesized radionuclides; distributively delivering the radionuclides in appropriate quantities to modular cassette synthesis units in a modular cassette subsystem for contemporaneous/parallel production of radiopharmaceutical output and that allow reuse and/or quick, safe, and disposable replacement of portions of the subsystem; delivering non-radionuclide components to the modular cassette synthesis units as part of production of radiopharmaceutical output; measuring the quantity and activity level of each stream of radiopharmaceutical output; purifying the radiopharmaceutical output; dispensing individual doses in sterile vial(s); automatically producing labeling and dose related information; performing automated quality control on extracted samples of produced radiopharmaceutical output; and providing software and hardware controls for overall and sub-portion operation for optional remote data collection, communication, and/or control.