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公开(公告)号：US10899713B2
公开(公告)日：2021-01-26
申请号：US16421671
申请日：2019-05-24
发明人： Ranjit C. Desai , Rajiv Sharma , Vrajesh Pandya , Kalpesh Shah , Sunil Patel , Rakesh Chauhan , Ranjeet Nair , Vivek Joshi , Manoj Patel , Mrigendra Shukla
IPC分类号： C07D215/58 , C07D215/56
摘要： The present invention relates to an improved process for the preparation of quinolone based compounds of general formula (I) using intermediate compound of general formula (XII). Invention also provides an improved process for the preparation of compound of formula (I-a) using intermediate compound of formula (XII-a) and some novel impurities generated during process. Compounds prepared using this process can be used to treat anemia.
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公开(公告)号：US10011609B2
公开(公告)日：2018-07-03
申请号：US15034661
申请日：2014-11-03
IPC分类号： C07D513/04 , C07D491/08 , A61K31/404 , A61K31/407 , A61K31/4162 , A61K31/4365 , A61K31/437 , A61K31/439 , A61K31/47 , A61K31/472 , A61K31/4985 , A61K31/519 , C07D215/06 , C07D215/20 , C07D217/04 , C07D471/04 , C07D487/04 , C07D491/04 , C07D207/08 , C07D207/20 , C07D495/04 , C07D498/04 , C07D209/12 , A61K31/40 , A61K31/435 , A61K31/4375 , A61K31/4453 , A61K31/496 , C07D207/06 , C07D209/08 , C07D209/44 , C07D295/096 , C07D491/048 , C07F3/00
CPC分类号： C07D513/04 , A61K31/40 , A61K31/404 , A61K31/407 , A61K31/4162 , A61K31/435 , A61K31/4365 , A61K31/437 , A61K31/4375 , A61K31/439 , A61K31/4453 , A61K31/47 , A61K31/472 , A61K31/496 , A61K31/4985 , A61K31/519 , C07D207/06 , C07D207/08 , C07D207/20 , C07D209/08 , C07D209/12 , C07D209/44 , C07D215/06 , C07D215/20 , C07D217/04 , C07D295/096 , C07D471/04 , C07D487/04 , C07D491/04 , C07D491/048 , C07D491/08 , C07D495/04 , C07D498/04 , C07F3/00
摘要： The present invention relates to novel GPR 40 agonists of the general formula (I), their tautomeric forms, their stereoisomers, their pharmaceutically acceptable salts, pharmaceutical compositions containing them, methods for their preparation, use of these compounds in medicine and the intermediates involved in their preparation.
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公开(公告)号：US09598418B2
公开(公告)日：2017-03-21
申请号：US14647088
申请日：2013-12-23
IPC分类号： C07D498/04 , C07D487/04 , C07D237/32 , C07D491/048 , C07D495/04 , C07D513/04 , C07D403/10
CPC分类号： C07D487/04 , C07D237/32 , C07D403/10 , C07D491/048 , C07D495/04 , C07D498/04 , C07D513/04
摘要： The present invention relates to novel compounds of general formula (I), their stereoisomers, regioisomers, tautomeric forms and novel intermediates involved in their synthesis, their pharmaceutically acceptable salts, pharmaceutically acceptable solvates and pharmaceutical compositions containing them. The present invention also relates to a process of preparing novel compounds of general formula (I), their stereoisomers, regioisomers, their tautomeric forms, their pharmaceutically acceptable salts, pharmaceutically acceptable solvates, pharmaceutical compositions containing them, and novel intermediates involved in their synthesis.
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公开(公告)号：US10246470B2
公开(公告)日：2019-04-02
申请号：US16002007
申请日：2018-06-07
IPC分类号： C07D513/04 , C07F3/00 , C07D209/08 , C07D209/44 , C07D295/096 , C07D491/048 , C07D207/06 , C07D209/12 , C07D498/04 , C07D495/04 , C07D207/20 , C07D207/08 , C07D491/04 , C07D487/04 , C07D471/04 , C07D217/04 , C07D215/20 , C07D215/06 , A61K31/519 , A61K31/4985 , A61K31/472 , A61K31/47 , A61K31/439 , A61K31/437 , A61K31/4365 , A61K31/4162 , A61K31/407 , A61K31/404 , C07D491/08 , A61K31/496 , A61K31/4453 , A61K31/4375 , A61K31/435 , A61K31/40
摘要： The present invention relates to a compound (3S)-3-(4-((3-(6-Oxa-3-azabicyclo[3.1.1]heptan-3-ylmethyl)benzyl)oxy)phenyl)hex-4-ynoic acid methods for use of this and other compounds.
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公开(公告)号：US09394300B2
公开(公告)日：2016-07-19
申请号：US14652024
申请日：2013-12-23
IPC分类号： C07D215/58 , A61K31/4704 , C07D471/04 , C07D215/60 , C07D401/04 , C07D401/12 , C07D413/04 , C07D417/12 , C07D491/04 , C07D495/04 , C07D513/04 , C07D409/04
CPC分类号： C07D471/04 , A61K31/4704 , C07D215/58 , C07D215/60 , C07D401/04 , C07D401/12 , C07D409/04 , C07D413/04 , C07D417/12 , C07D491/04 , C07D495/04 , C07D513/04
摘要： The present invention relates to novel compounds of the general formula (I), their tautomeric forms, their stereoisomers, their pharmaceutically acceptable salts, pharmaceutical compositions containing them, methods for their preparation, use of these compounds in medicine and the intermediates involved in their preparation.
摘要翻译： 本发明涉及通式（I）的新化合物，其互变异构形式，其立体异构体，其药学上可接受的盐，含有它们的药物组合物，其制备方法，这些化合物在医药中的用途以及参与其制备的中间体 。
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公开(公告)号：US09840509B2
公开(公告)日：2017-12-12
申请号：US15112536
申请日：2015-02-02
发明人： Ranjit C. Desai , Rajesh Bahekar , Dipam Patel , Kiran Shah
IPC分类号： C07D487/04 , C07D473/34 , A61K31/4985 , A61K31/522 , A61K31/5377 , A61K31/55 , A61K31/519 , A61K45/06
CPC分类号： C07D487/04 , A61K31/4985 , A61K31/519 , A61K31/522 , A61K31/5377 , A61K31/55 , A61K45/06 , C07D473/34
摘要： The present invention relates to heterocyclic compounds of the general formula (I) their pharmaceutically acceptable salts, pharmaceutically acceptable solvates, enantiomers, diastereomers, and polymorphs. The invention also relates to processes for the preparation of the compounds of invention, pharmaceutical compositions containing the compounds and their use as selective Bruton's Tyrosine Kinase (BTK) inhibitors.
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公开(公告)号：US20150299193A1
公开(公告)日：2015-10-22
申请号：US14652024
申请日：2013-12-23
IPC分类号： C07D471/04 , C07D409/04 , C07D401/12 , C07D215/58 , C07D417/12
CPC分类号： C07D471/04 , A61K31/4704 , C07D215/58 , C07D215/60 , C07D401/04 , C07D401/12 , C07D409/04 , C07D413/04 , C07D417/12 , C07D491/04 , C07D495/04 , C07D513/04
摘要： The present invention relates to novel compounds of the general formula (I), their tautomeric forms, their stereoisomers, their pharmaceutically acceptable salts, pharmaceutical compositions containing them, methods for their preparation, use of these compounds in medicine and the intermediates involved in their preparation.
摘要翻译： 本发明涉及通式（I）的新化合物，其互变异构形式，其立体异构体，其药学上可接受的盐，含有它们的药物组合物，其制备方法，这些化合物在医药中的用途以及参与其制备的中间体 。
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8.发明申请SUBSTITUTED PHTHALAZIN-1 (2H)-ONE DERIVATIVES AS SELECTIVE INHIBITORS OF POLY (ADP-RIBOSE) POLYMERASE-1 有权取代的苯乙酮-1（2H） - 酮衍生物作为聚（ADP-赖酮）聚合酶-1的选择性抑制剂公开(公告)号：US20150291603A1
公开(公告)日：2015-10-15
申请号：US14647088
申请日：2013-12-13
IPC分类号： C07D487/04 , C07D513/04 , C07D498/04 , C07D491/048 , C07D403/10
CPC分类号： C07D487/04 , C07D237/32 , C07D403/10 , C07D491/048 , C07D495/04 , C07D498/04 , C07D513/04
摘要： The present invention relates to novel compounds of general formula (I), their stereoisomers, regioisomers, tautomeric forms and novel intermediates involved in their synthesis, their pharmaceutically acceptable salts, pharmaceutically acceptable solvates and pharmaceutical compositions containing them. The present invention also relates to a process of preparing novel compounds of general formula (I), their stereoisomers, regioisomers, their tautomeric forms, their pharmaceutically acceptable salts, pharmaceutically acceptable solvates, pharmaceutical compositions containing them, and novel intermediates involved in their synthesis.
摘要翻译： 本发明涉及通式（I）的新型化合物，其立体异构体，区域异构体，互变异构形式和参与其合成的新中间体，其药学上可接受的盐，药学上可接受的溶剂合物和含有它们的药物组合物。 本发明还涉及制备通式（I）的新化合物，其立体异构体，区域异构体，其互变异构形式，其药学上可接受的盐，药学上可接受的溶剂合物，含有它们的药物组合物以及参与其合成的新型中间体的方法。
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9.发明申请2-PHENYL-5-HETEROCYCLYL-TETRAHYDRO-2H-PYRAN-3-AMINE COMPOUNDS FOR USE IN THE TREATMENT OF DIABETES AND ITS ASSOCIATED DISORDERS 审中-公开用于治疗糖尿病及其相关疾病的2-苯基-5-间苯二甲酸四氢-2H- -2H-吡喃-3-胺化合物公开(公告)号：US20150246025A1
公开(公告)日：2015-09-03
申请号：US14436504
申请日：2013-10-17
IPC分类号： A61K31/437 , A61K31/407 , A61K45/06 , C07D487/10 , A61K31/403 , C07D471/04 , C07D471/10 , A61K31/435 , C07D405/04 , C07D487/04 , C07D491/048
CPC分类号： A61K31/437 , A61K31/403 , A61K31/407 , A61K31/435 , A61K45/06 , C07D405/04 , C07D471/04 , C07D471/10 , C07D487/04 , C07D487/10 , C07D491/04 , C07D491/048 , C07D495/04
摘要： The present invention relates to novel compounds of the general formula (I) their tautomeric forms, their enantiomers, their diastereoisomers, their pharmaceutically accepted salts, or pro-drugs thereof, which are useful for the treatment or prevention of diabetes mellitus (DM), obesity and other metabolic disorders. The invention also relates to process for the manufacture of said compounds, and pharmaceutical compositions containing them and their use.
摘要翻译： 本发明涉及用于治疗或预防糖尿病（DM）的通式（I）的新型化合物，其互变异构形式，其对映异构体，其非对映异构体，其药学上可接受的盐或其前体药物， 肥胖等代谢紊乱。 本发明还涉及制备所述化合物的方法和含有它们的药物组合物及其用途。
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