公开(公告)号：US20180051074A1

公开(公告)日：2018-02-22

申请号：US15799255

申请日：2017-10-31

申请人： Cornell University

发明人： Xiaojing Ma

IPC分类号： C07K16/18 ,  C12N15/113 ,  C07K16/30

CPC分类号： C07K16/18 ,  C07K16/303 ,  C07K2317/76 ,  C12N15/113 ,  C12N15/1138 ,  C12N2310/11 ,  C12N2310/14

摘要： This disclosure provides a method for enhancing cell-mediated immunity in individuals with disorders such as cancer or infection that involves administering an inhibitor of GOLPH2 to the individuals. For example, inhibition of GOLPH2 increases the endogenous production of IL-12.

公开(公告)号：USRE49816E1

公开(公告)日：2024-01-30

申请号：US16893086

申请日：2020-06-04

申请人： CORNELL UNIVERSITY

发明人： Gang Lin ,  Carl Nathan ,  Aihao Ding ,  Xiaojing Ma

IPC分类号： C07K5/072 ,  C07K5/078 ,  C07K5/062 ,  C07K5/097 ,  C07K5/083 ,  C07K5/06 ,  C07K5/068 ,  A61K38/00

CPC分类号： C07K5/06104 ,  C07K5/0606 ,  C07K5/06026 ,  C07K5/06069 ,  C07K5/06086 ,  C07K5/06113 ,  C07K5/06139 ,  C07K5/06191 ,  C07K5/0806 ,  C07K5/0821 ,  A61K38/00

摘要： The compounds of the present invention are represented by the following compounds having Formula (I) where the substituents R1-R10, X, Y, k, m, n, q, and s are as defined herein. These compounds are used in the treatment of cancer, immunologic disorders, autoimmune disorders, neurodegenerative disorders, or inflammatory disorders or for providing immunosuppression for transplanted organs or tissues.

公开(公告)号：US09988421B2

公开(公告)日：2018-06-05

申请号：US15110000

申请日：2015-01-12

申请人： CORNELL UNIVERSITY

发明人： Gang Lin ,  Carl Nathan ,  Aihao Ding ,  Xiaojing Ma

IPC分类号： A61K38/00 ,  C07K5/072 ,  C07K5/06 ,  C07K5/062 ,  C07K5/068 ,  C07K5/078 ,  C07K5/097

CPC分类号： C07K5/06104 ,  A61K38/00 ,  C07K5/06026 ,  C07K5/0606 ,  C07K5/06069 ,  C07K5/06086 ,  C07K5/06113 ,  C07K5/06139 ,  C07K5/06191 ,  C07K5/0806 ,  C07K5/0821

摘要： The compounds of the present invention are represented by the following compounds having Formula (I) where the substituents R1-R10, X, Y, k, m, n, q, and s are as defined herein. These compounds are used in the treatment of cancer, immunologic disorders, autoimmune disorders, neurodegenerative disorders, or inflammatory disorders or for providing immunosuppression for transplanted organs or tissues.