- 专利标题： Dipeptides as inhibitors of human immunoproteasomes
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申请号： US16893086申请日： 2020-06-04
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公开(公告)号： USRE49816E1公开(公告)日： 2024-01-30
- 发明人: Gang Lin , Carl Nathan , Aihao Ding , Xiaojing Ma
- 申请人： CORNELL UNIVERSITY
- 申请人地址： US NY Ithaca
- 专利权人： CORNELL UNIVERSITY
- 当前专利权人： CORNELL UNIVERSITY
- 当前专利权人地址： US NY Ithaca
- 代理机构： Troutman Pepper Hamilton Sanders LLP (Rochester)
- 国际申请： PCT/US2015/011022 2015.01.12
- 国际公布： WO2015/106200A 2015.07.16
- 进入国家日期： 2016-07-06
- 主分类号： C07K5/072
- IPC分类号： C07K5/072 ; C07K5/078 ; C07K5/062 ; C07K5/097 ; C07K5/083 ; C07K5/06 ; C07K5/068 ; A61K38/00
摘要：
The compounds of the present invention are represented by the following compounds having Formula (I) where the substituents R1-R10, X, Y, k, m, n, q, and s are as defined herein. These compounds are used in the treatment of cancer, immunologic disorders, autoimmune disorders, neurodegenerative disorders, or inflammatory disorders or for providing immunosuppression for transplanted organs or tissues.
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