公开(公告)号：US09988421B2

公开(公告)日：2018-06-05

申请号：US15110000

申请日：2015-01-12

Applicant: CORNELL UNIVERSITY

Inventor： Gang Lin ,  Carl Nathan ,  Aihao Ding ,  Xiaojing Ma

IPC: A61K38/00 ,  C07K5/072 ,  C07K5/06 ,  C07K5/062 ,  C07K5/068 ,  C07K5/078 ,  C07K5/097

CPC classification number: C07K5/06104 ,  A61K38/00 ,  C07K5/06026 ,  C07K5/0606 ,  C07K5/06069 ,  C07K5/06086 ,  C07K5/06113 ,  C07K5/06139 ,  C07K5/06191 ,  C07K5/0806 ,  C07K5/0821

Abstract: The compounds of the present invention are represented by the following compounds having Formula (I) where the substituents R1-R10, X, Y, k, m, n, q, and s are as defined herein. These compounds are used in the treatment of cancer, immunologic disorders, autoimmune disorders, neurodegenerative disorders, or inflammatory disorders or for providing immunosuppression for transplanted organs or tissues.

公开(公告)号：USRE49816E1

公开(公告)日：2024-01-30

申请号：US16893086

申请日：2020-06-04

Applicant: CORNELL UNIVERSITY

Inventor： Gang Lin ,  Carl Nathan ,  Aihao Ding ,  Xiaojing Ma

IPC: C07K5/072 ,  C07K5/078 ,  C07K5/062 ,  C07K5/097 ,  C07K5/083 ,  C07K5/06 ,  C07K5/068 ,  A61K38/00

CPC classification number: C07K5/06104 ,  C07K5/0606 ,  C07K5/06026 ,  C07K5/06069 ,  C07K5/06086 ,  C07K5/06113 ,  C07K5/06139 ,  C07K5/06191 ,  C07K5/0806 ,  C07K5/0821 ,  A61K38/00

Abstract: The compounds of the present invention are represented by the following compounds having Formula (I) where the substituents R1-R10, X, Y, k, m, n, q, and s are as defined herein. These compounds are used in the treatment of cancer, immunologic disorders, autoimmune disorders, neurodegenerative disorders, or inflammatory disorders or for providing immunosuppression for transplanted organs or tissues.