公开(公告)号：US20250063641A1

公开(公告)日：2025-02-20

申请号：US18929485

申请日：2024-10-28

Applicant: Cornell University

Inventor： James C. M. Hwang ,  Mohammad Javad Asadi ,  Gianluca Fabi ,  Chandrashekhar P. Savant

IPC: H05B6/72 ,  H01L21/324 ,  H01L21/66 ,  H01L21/67 ,  H05B6/68

Abstract: Technologies for microwave annealing include a chamber, a heating device configured to heat a substrate borne within the chamber during system operation, a microwave source configured to direct microwave energy at a predetermined frequency to a location within the chamber at which the substrate is disposed, and an elongated waveguide disposed within the chamber and extending between the microwave source and the location within the chamber at which the substrate is disposed. The substrate may be a semiconductor doped by ion implantation or epitaxial growth. During operation, the microwave energy activates a dopant and/or breaks up a defect cluster within the substrate.

公开(公告)号：US12226492B2

公开(公告)日：2025-02-18

申请号：US16959090

申请日：2018-12-28

Applicant: Cornell University

Inventor： Ronald G. Crystal ,  Odelya E. Pagovich ,  Katie Stiles

IPC: C07K16/44 ,  A61K48/00 ,  C07K16/28 ,  C12N15/86

Abstract: Compositions and methods for eosinophilia in a mammal are provided. In one embodiment, the composition is a viral gene therapy vector, and a single dose of the vector reduces increased numbers of eosinophils in a mammal.

公开(公告)号：US20250047685A1

公开(公告)日：2025-02-06

申请号：US18652281

申请日：2024-05-01

Applicant: Cornell University

Inventor： Fan ZHANG ,  Sai Krishna Deepak MARAM ,  Harjasleen MALVAI ,  Steven GOLDFEDER ,  Ari JUELS

IPC: H04L9/40

Abstract: A verifier device in one embodiment is configured to communicate over one or more networks with a client device and a server device. The verifier device participates in a three-party handshake protocol with the client device and the server device in which the verifier device and the client device obtain respective shares of a session key of a secure session with the server device. The verifier device receives from the client device a commitment relating to the secure session with the server device, and responsive to receipt of the commitment, releases to the client device additional information relating to the secure session that was not previously accessible to the client device. The verifier device verifies correctness of at least one characterization of data obtained by the client device from the server device as part of the secure session, based at least in part on the commitment and the additional information.

公开(公告)号：US12215127B2

公开(公告)日：2025-02-04

申请号：US17231432

申请日：2021-04-15

Applicant: CORNELL UNIVERSITY

Inventor： Pamela Chang ,  Bibudha Parasar ,  Lin Han

IPC: C07J43/00 ,  G01N33/68

Abstract: A composition having the following structure: wherein: R1 is OH, ester group, ether group, amine, thiol, thioether, halide, or a group containing an alkynyl or azido functionality; R2 is H, OH, ester group, ether group, amine, thiol, thioether, halide, or a group containing an alkynyl or azido functionality; R3 is a group containing a reactive functionality capable of covalent binding to a thiol or amine; and R4 is H, OH, ester group, ether group, amine, thiol, thioether, halide, or a group containing an alkynyl or azido functionality; wherein one of R1, R2 and R4 is a group containing an alkynyl or azido functionality. Also disclosed is a method for profiling changes in BSH enzyme activity by attaching active BSH enzymes in a sample to the probe shown above, attaching a tag to the probe, and detecting the active BSH enzymes to obtain an activity profile.

公开(公告)号：US20250034604A1

公开(公告)日：2025-01-30

申请号：US18716659

申请日：2022-12-06

Applicant: CORNELL UNIVERSITY

Inventor： Jeremy BASKIN ,  Reika TEI

IPC: C12P7/6481 ,  C12N9/16 ,  C12P7/6409

Abstract: Engineered phospholipase D mutants are described herein. Also described herein are methods of making engineered phospholipase D mutants. Additionally, methods of using engineered phospholipase D mutants are described.

公开(公告)号：US20250027105A1

公开(公告)日：2025-01-23

申请号：US18773683

申请日：2024-07-16

Applicant: Natural Resources Institute ,  Yissum Research Development Company of The Hebrew University of Jerusalem LTD ,  Cornell University ,  Donald Danforth Plant Science Center ,  National Agricultural Research Organization

Inventor： John Colvin ,  Sharon L. van Brunschot ,  Rekha Swamy ,  Susan Seal ,  Shai Morin ,  Osnat Malka ,  Dor Wintraube ,  Nigel Taylor ,  Narayanan Narayanan ,  Titus Alicai ,  Tadeo Kaweesi

IPC: C12N15/82 ,  C12N15/113

Abstract: The present disclosure is directed to controlling pest infestation by inhibiting one or more biological functions in an invertebrate pest. The disclosure discloses methods and compositions for use in controlling pest infestation by feeding one or more different recombinant double stranded RNA molecules to the pest in order to achieve a reduction in pest infestation through suppression of gene expression. The disclosure also discloses methods and compositions for targeted genome editing in the pest in order to achieve a reduction in pest infestation through disruption of protein activity. The disclosure is also directed to methods for making transgenic plants that express the double stranded RNA molecules and targeted genome editing constructs for use in protecting plants from pest infestation.

公开(公告)号：US20250027069A1

公开(公告)日：2025-01-23

申请号：US18707464

申请日：2022-11-08

Applicant: Cornell University

Inventor： Myat T. LIN ,  Maureen HANSON

IPC: C12N9/88 ,  C12N15/82

Abstract: Provided herein are genetically engineered Rubisco enzymes and plants comprising the same. In one aspect, the disclosure features a genetically engineered plant comprising a Rubisco large subunit (LSU) comprising L2251 and K429Q amino acid substitution mutations, wherein the amino acid substitution mutations are numbered relative to the LSU of Nicotiana tabacum; and a Rubisco small subunit (SSU comprising N8G, V301, and E88Q amino acid substitution mutations, wherein the amino acid substitution mutations are numbered relative to the S-T2 subunit of Nicotiana tabacum.

公开(公告)号：US20250019249A1

公开(公告)日：2025-01-16

申请号：US18616147

申请日：2024-03-25

Applicant: CORNELL UNIVERSITY

Inventor： Melik Z. Turker ,  Thomas C. Gardinier, II ,  Ulrich B. Wiesner ,  Kai Ma

IPC: C01B33/12 ,  A61K9/51 ,  A61K33/00 ,  A61K49/00 ,  A61K51/12

Abstract: Silica nanorings, methods of making silica nanorings, and uses of silica nanorings. The silica nanorings may be PEGylated. The silica nanorings may be surface functionalized, which may be surface selective functionalization, with one or more polyethylene glycol (PEG) group(s), one or more display group(s), one or more functional group(s), or a combination thereof. The silica nanorings may have a size of 5 to 20 nm. The silica nanorings may be made using micelles. The absence or presence of the micelles during PEGylation and/or functionalization allows for surface selective functionalization. The silica nanorings may be used in various diagnostic and/or treatment methods.

公开(公告)号：USRE50268E1

公开(公告)日：2025-01-14

申请号：US17716019

申请日：2022-04-08

Applicant: International AIDS Vaccine Initiative ,  The Scripps Research Institute ,  Cornell University

Inventor： Dennis R. Burton ,  Marit J. Van Gils ,  Wayne Koff ,  Pascal R. G. Poignard ,  Rogier W. Sanders ,  Melissa D. J. S. Simek-Lemos ,  Devin Sok

IPC: C07K16/10

Abstract: The present invention relates to an exceptionally broad and potent neutralizing antibody which may comprise cross-clade neutralizing coverage of 83% at a median IC50 of 0.003 μg/ml, compositions containing the same and uses thereof.

公开(公告)号：US20250009805A1

公开(公告)日：2025-01-09

申请号：US18708322

申请日：2022-11-08

Applicant: CORNELL UNIVERSITY

Inventor： David Lin

IPC: A61K35/30 ,  A61P25/00 ,  C12N5/0793

Abstract: Described in several embodiments herein are olfactory sensory neuron (OSN) derived extracellular vehicles (EVs), formulations thereof, and uses thereof. In some embodiments, the OSN derived extracellular vesicles are effective to increase the growth of neurons during regeneration. In some embodiments, the OSN derived EVs and/or formulations thereof are used to promote nerve regeneration, particularly peripheral nerve regeneration, and to treat nerve injury.