公开(公告)号：US20200048713A1

公开(公告)日：2020-02-13

申请号：US16500929

申请日：2018-04-05

Applicant: CORNELL UNIVERSITY

Inventor： Iwijn DE VLAMINCK ,  John Richard LEE ,  Philip Smith BURNHAM ,  Alexandre Pellan CHENG ,  Manikkam SUTHANTHRIAN ,  Darshana DADHANIA

IPC: C12Q1/6883 ,  C12Q1/689 ,  C12Q1/70 ,  C40B30/06

Abstract: The present disclosure is directed to methods of detecting cell-free DNA (cfDNA) in biological samples and using it to quantify organ damage and identify pathogens. In some aspects, the biological samples are from patients who have undergone solid-organ transplantation. The disclosure is also directed to methods of detecting and analyzing methylation patterns in cell-free DNA from organ transplant patients to identify the presence of pathogens as well as quantify contributing tissue proportions as a measurement of the host response.

公开(公告)号：US20240026456A1

公开(公告)日：2024-01-25

申请号：US18458199

申请日：2023-08-30

Applicant: CORNELL UNIVERSITY

Inventor： Iwijn DE VLAMINCK ,  John Richard LEE ,  Philip Smith BURNHAM ,  Alexandre Pellan CHENG ,  Manikkam SUTHANTHRIAN ,  Darshana M. DADHANIA

IPC: C12Q1/6883 ,  C12Q1/689 ,  C12Q1/70 ,  C40B30/06

CPC classification number: C12Q1/6883 ,  C12Q1/689 ,  C12Q1/701 ,  C40B30/06 ,  C12Q2600/154 ,  C12Q2600/156 ,  C12Q2600/158

Abstract: The present disclosure is directed to methods of detecting cell-free DNA (cfDNA) in biological samples and using it to quantify organ damage and identify pathogens. In some aspects, the biological samples are from patients who have undergone solid-organ transplantation. The disclosure is also directed to methods of detecting and analyzing methylation patterns in cell-free DNA from organ transplant patients to identify the presence of pathogens as well as quantify contributing tissue proportions as a measurement of the host response.