公开(公告)号：US20230391890A1

公开(公告)日：2023-12-07

申请号：US18249187

申请日：2021-10-15

申请人： CORNELL UNIVERSITY ,  TRI-INSTITUTIONAL THERAPEUTICS DISCOVERY INSTITUTE

发明人： David C. LYDEN ,  Goncalo RODRIGUES ,  Irena RAJNPREHT ,  Abdul KHAN ,  Ivo LORENZ ,  Irina MATEI

IPC分类号： C07K16/40 ,  A61P35/04

CPC分类号： C07K16/40 ,  A61P35/04 ,  C07K2317/76 ,  C07K2317/92

摘要： The present disclosure relates to antibody-based molecules, including antibodies, epitope-binding domains thereof, and antibody derivative as described herein, that are capable of binding and inhibiting cell migration-inducing and hyaluronan-binding protein (CEMIP). Such antibody-based molecules are useful for the treatment of conditions where a subject is in need of blocking the activity of CEMIP.

公开(公告)号：US20240000959A1

公开(公告)日：2024-01-04

申请号：US18039369

申请日：2021-11-30

申请人： CORNELL UNIVERSITY

发明人： Neil H. BANDER ,  Wilhem LECONET ,  Ming GUO ,  He LIU ,  Ivo LORENZ ,  Abdul G. KHAN

IPC分类号： A61K47/66 ,  C07K16/28 ,  C07K16/30 ,  A61P35/00 ,  C12N9/10

CPC分类号： A61K47/67 ,  C07K16/2803 ,  C07K16/3069 ,  A61P35/00 ,  C12N9/1051 ,  C12Y204/01069 ,  C12Y204/01087 ,  C07K2317/55 ,  C07K2317/622 ,  A61K2039/505

摘要： The present application relates to a bi-functional therapeutic for treating cancer that includes a targeting component which targets a tumor-associated antigen and an enzyme which, when delivered to a tumor by said targeting component, converts the tumor phenotype to that of an incompatible allograft or xenograft. The enzyme is coupled to the targeting component. Also disclosed is a method for treating cancer comprising administering the bi-functional therapeutic.