公开(公告)号：US11085029B2

公开(公告)日：2021-08-10

申请号：US17076057

申请日：2020-10-21

Applicant: CJ CHEILJEDANG CORPORATION

Inventor： Ae Ji Jeon ,  Byeong Cheol Song ,  Ji Hye Lee ,  Jong Hyun Kim ,  Hye Won Kim

IPC: C12N9/10 ,  C12P13/06 ,  C12P13/08

Abstract: The present disclosure relates to a novel acetohydroxy acid synthase, a microorganism comprising the same, or a method for producing an L-branched-chain amino acid using the same.

公开(公告)号：US20190071652A1

公开(公告)日：2019-03-07

申请号：US16195157

申请日：2018-11-19

Applicant: CJ CHEILJEDANG CORPORATION

Inventor： Ae Ji Jeon ,  Byeong Cheol Song ,  Jong Hyun Kim ,  Hye Won Kim ,  Ji Hye Lee

IPC: C12N9/10 ,  C12N9/88 ,  C12P13/08 ,  C12R1/15

Abstract: The present disclosure relates to an acetohydroxy acid synthase variant in which the feedback inhibition to L-valine is released, a polynucleotide encoding the acetohydroxy acid synthase variant, an expression vector including the polynucleotide, a microorganism producing L-valine including the acetohydroxy acid synthase variant, and a method for producing L-valine using the microorganism.

公开(公告)号：US11021697B2

公开(公告)日：2021-06-01

申请号：US16692558

申请日：2019-11-22

Applicant: CJ CHEILJEDANG CORPORATION

Inventor： Ae Ji Jeon ,  Byeong Cheol Song ,  Ji Hye Lee ,  Jong Hyun Kim ,  Hye Won Kim

IPC: C12N9/10 ,  C12N9/88 ,  C12P13/06 ,  C12P13/08 ,  C12N15/77

Abstract: The present disclosure relates to a novel acetohydroxy acid synthase, a microorganism comprising the same, or a method for producing an L-branched-chain amino acid using the same.

公开(公告)号：US10072278B2

公开(公告)日：2018-09-11

申请号：US14771969

申请日：2014-03-05

Applicant: CJ Cheiljedang Corporation

Inventor： Hye Won Kim ,  Ji Hye Lee ,  Byeong Cheol Song ,  Jong Hyun Kim ,  Han Hyoung Lee ,  Ae Ji Jeon

IPC: C12P13/08 ,  C07K7/06 ,  C12N15/52 ,  C12N15/77

Abstract: The present invention relates to a novel L-valine-producing strain which is transformed so as to strengthen the expression of L-valine operon by having a nucleotide sequence, for coding a leader peptide in a regulatory region of ilvBN operon, entirely deleted, or partially deleted or substituted. In addition, the present invention relates to a method for producing L-valine using the novel L-valine-producing strain. According to the novel valine-producing strain and the L-valine production method of the present invention using the strain, there is an advantageous effect of producing L-valine at high efficiency and high yield.

公开(公告)号：US20160108444A1

公开(公告)日：2016-04-21

申请号：US14771969

申请日：2014-03-05

Applicant: CJ CHEILJEDANG CORPORATION

Inventor： Hye Won Kim ,  Ji Hye Lee ,  Byeong Cheol Song ,  Jong Hyun Kim ,  Han Hyoung Lee ,  Ae Ji Jeon

IPC: C12P13/08 ,  C07K7/06 ,  C12N15/77

CPC classification number: C12P13/08 ,  C07K7/06 ,  C12N15/52 ,  C12N15/77

Abstract: The present invention relates to a novel L-valine-producing strain which is transformed so as to strengthen the expression of L-valine operon by having a nucleotide sequence, for coding a leader peptide in a regulatory region of ilvBN operon, entirely deleted, or partially deleted or substituted. In addition, the present invention relates to a method for producing L-valine using the novel L-valine-producing strain. According to the novel valine-producing strain and the L-valine production method of the present invention using the strain, there is an advantageous effect of producing L-valine at high efficiency and high yield.

Abstract translation: 本发明涉及一种新的L-缬氨酸生产菌株，其通过具有编码ilvBN操纵子的调节区中的前导肽的核苷酸序列而被完全缺失而被转化以加强L-缬氨酸操纵子的表达，或 部分删除或替代。 此外，本发明涉及使用新型L-缬氨酸生产菌株生产L-缬氨酸的方法。 根据使用该菌株的本发明的新型缬氨酸生产菌株和L-缬氨酸生产方法，具有以高效率和高收率生产L-缬氨酸的有利效果。

公开(公告)号：US12139733B2

公开(公告)日：2024-11-12

申请号：US17044726

申请日：2019-12-24

Applicant: CJ CHEILJEDANG CORPORATION

Inventor： Jaehun Lee ,  Hee-See Moon ,  Ae Ji Jeon ,  Young Lyeol Yang ,  Byung-Gee Kim ,  Eun Young Hong

IPC: C12N9/88 ,  C12P13/00

Abstract: The present application relates to a variant of ornithine decarboxylase or protein, a polynucleotide encoding the same, a microorganism containing the same, and a method for producing putrescine using the same.
The present invention achieves effects of increasing putrescine productivity, production efficiency or production selectivity, suppressing side reactions, and saving the cost involved in purifying putrescine.

公开(公告)号：US11104924B2

公开(公告)日：2021-08-31

申请号：US16473941

申请日：2017-10-20

Applicant: CJ Cheiljedang Corporation

Inventor： Ji Hye Lee ,  Byeong Cheol Song ,  Ae Ji Jeon ,  Jong Hyun Kim ,  Hye Won Kim

IPC: C12N9/00 ,  C12P13/06 ,  C12N9/10 ,  C12N15/52 ,  C12N15/77

Abstract: A novel modified polypeptide having an isopropylmalate synthase activity, a polynucleotide encoding the same, a microorganism comprising the polypeptide, and a method of producing L-leucine by culturing the microorganism.

公开(公告)号：US10457919B2

公开(公告)日：2019-10-29

申请号：US16195157

申请日：2018-11-19

Applicant: CJ CHEILJEDANG CORPORATION

Inventor： Ae Ji Jeon ,  Byeong Cheol Song ,  Jong Hyun Kim ,  Hye Won Kim ,  Ji Hye Lee

IPC: C12P13/08 ,  C12N9/10 ,  C12N9/88 ,  C12R1/15

Abstract: The present disclosure relates to an acetohydroxy acid synthase variant in which the feedback inhibition to L-valine is released, a polynucleotide encoding the acetohydroxy acid synthase variant, an expression vector including the polynucleotide, a microorganism producing L-valine including the acetohydroxy acid synthase variant, and a method for producing L-valine using the microorganism.

公开(公告)号：US10316297B2

公开(公告)日：2019-06-11

申请号：US15501645

申请日：2015-08-05

Applicant: CJ CHEILJEDANG CORPORATION

Inventor： Ae Ji Jeon ,  Byeong Cheol Song ,  Jong Hyun Kim ,  Hye Won Kim ,  Ji Hye Lee

IPC: C12P13/08 ,  C12N9/10 ,  C12N9/88 ,  C12R1/15

Abstract: The present disclosure relates to an acetohydroxy acid synthase variant in which the feedback inhibition to L-valine is released, a polynucleotide encoding the acetohydroxy acid synthase variant, an expression vector including the polynucleotide, a microorganism producing L-valine including the acetohydroxy acid synthase variant, and a method for producing L-valine using the microorganism.

公开(公告)号：US09885093B2

公开(公告)日：2018-02-06

申请号：US14898099

申请日：2013-06-11

Applicant: CJ CHEILJEDANG CORPORATION

Inventor： Hye Won Kim ,  Ji Hye Lee ,  Jong Hyun Kim ,  Han Hyoung Lee ,  Ae Ji Jeon

IPC: C12P13/06 ,  C12N1/20 ,  C12R1/15 ,  C12P13/08 ,  C12N15/01

CPC classification number: C12R1/15 ,  C12N1/20 ,  C12P13/06 ,  C12P13/08

Abstract: The present invention relates to a microorganism having an enhanced ability to produce L-isoleucine and a method of producing L-isoleucine using the same. More specifically, the present invention relates to a Corynebacterium glutamicum mutant strain, which is resistant to L-isoleucine and L-threonine derivatives and has an enhanced ability to produce L-isoleucine, and to a method of producing L-isoleucine using the mutant strain.