公开(公告)号：US20180207146A1

公开(公告)日：2018-07-26

申请号：US15327247

申请日：2015-07-20

Applicant: CHONG KUN DANG PHARMACEUTICAL CORP.

Inventor： Byoung Ki AHN ,  Ki Seong KO ,  So Hyun PARK ,  Min Hyo KI ,  Jong Lae LIM

IPC: A61K31/473 ,  A61K31/542 ,  A61K9/08 ,  A61K31/5415 ,  A61K31/405 ,  A61K31/407 ,  A61K9/00 ,  A61K47/14 ,  A61K47/24 ,  A61K47/28 ,  A61K47/22

CPC classification number: A61K31/473 ,  A61K9/0019 ,  A61K9/0095 ,  A61K9/08 ,  A61K31/135 ,  A61K31/405 ,  A61K31/407 ,  A61K31/4402 ,  A61K31/5415 ,  A61K31/542 ,  A61K31/573 ,  A61K31/58 ,  A61K45/06 ,  A61K47/14 ,  A61K47/22 ,  A61K47/24 ,  A61K47/28 ,  A61K2300/00

Abstract: Disclosed is a composition comprising a 5α-reductase inhibitor. Forming a liquid crystal upon exposure to an aqueous fluid, the composition can release the 5α-reductase inhibitor at a constant rate over a long period of time. In addition, the composition can significantly alleviate irritations attributed to the topical administration of the 5α-reductase inhibitor, and thus the composition has improved safety.

公开(公告)号：US20150374850A1

公开(公告)日：2015-12-31

申请号：US14764156

申请日：2014-02-28

Applicant: CHONG KUN DANG PHARMACEUTICAL CORP.

Inventor： Ho Young HWANG ,  Ji Hyeh HWANG ,  Young Nam LEE ,  Sang Myoung NOH ,  Min Hyo KI

IPC: A61K48/00 ,  C12N15/113 ,  A61K9/14 ,  A61K47/24 ,  A61K9/19 ,  A61K47/26 ,  A61K47/14 ,  A61K47/28 ,  A61K31/713 ,  A61K31/7088 ,  A61K47/36

CPC classification number: A61K48/0041 ,  A61K9/0019 ,  A61K9/1274 ,  A61K9/14 ,  A61K9/19 ,  A61K31/7088 ,  A61K31/713 ,  A61K31/722 ,  A61K47/14 ,  A61K47/24 ,  A61K47/26 ,  A61K47/28 ,  A61K47/36 ,  C12N15/111 ,  C12N15/113 ,  C12N2310/11 ,  C12N2310/12 ,  C12N2310/14 ,  C12N2320/32

Abstract: Disclosed herein is a composition for gene delivery which forms into liquid crystals in an aqueous fluid including chitosan and a liquid crystal formation material. The composition of the present invention including chitosan and a liquid crystal formation material improves the relatively low binding strength between chitosan and a gene, and also considerably increases the stability of a chitosan nanocomposite in blood serum, thereby performing highly efficient gene delivery and providing excellent stability, thus being useful as a gene therapeutic agent.

Abstract translation: 本文公开了一种用于基因递送的组合物，其在包含壳聚糖和液晶形成材料的含水流体中形成液晶。 包括壳聚糖和液晶形成材料的本发明的组合物改善了壳聚糖与基因之间的相对低的结合强度，并且还显着提高了血清中壳聚糖纳米复合物的稳定性，从而进行高效的基因递送并提供优异的稳定性 因此可用作基因治疗剂。