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公开(公告)号：US10717716B2
公开(公告)日：2020-07-21
申请号：US15750067
申请日：2016-08-04
发明人： Jaekwang Lee , Yuntae Kim , Chang Sik Lee , Hyeseung Song , Dal-Yong Gwak , Jaeyoung Lee , Jung Taek Oh , Chang Gon Lee , Il Hyang Kim
IPC分类号： C07D271/10 , C07D413/12 , C07D491/10 , C07D413/04 , A61P25/00 , C07D471/10 , A61P37/00 , C07D413/14 , C07D417/12 , A61P29/00 , C07D417/14 , A61P35/00
摘要： The present invention relates to novel compounds having histone deacetylase 6 (HDAC6) in-hibitory activity, stereoisomers thereof or pharmaceutically acceptable salts thereof the use thereof for the preparation of therapeutic medicaments, pharmaceutical compositions containing the same, a method for treating diseases using the composition, and methods for preparing the novel compounds. The novel compounds stereoisomers thereof or pharmaceutically acceptable salts thereof according to the present invention have histone deacetylase (HDAC) inhibitory activity and are effective for the prevention or treatment of HDAC6-mediated diseases, including infectious diseases; neoplasms; endocrine, nutritional and metabolic diseases; mental and be-havioral disorders; neurological diseases; diseases of the eye and adnexa; cardiovascular diseases; respiratory diseases; digestive diseases; diseases of the skin and subcutaneous tissue; diseases of the musculoskeletal system and connective tissue; or congenital malformations, deformations and chromosomal abnormalities.
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2.发明授权公开(公告)号：US10287255B2
公开(公告)日：2019-05-14
申请号：US15125256
申请日：2015-03-12
发明人： Hyeseung Song , Changgon Lee , Dalyong Kwak , Jaeyoung Lee , Suyeal Bae , Yuntae Kim , Daekwon Bae , Nina Ha , Miseon Bae , Jihyun Kim
IPC分类号： C07D241/04 , C07D401/06 , C07D401/10 , C07D401/12 , C07D403/06 , C07D403/10 , C07D403/12 , C07D405/06 , C07D405/10 , C07D405/12 , C07D409/06 , C07D409/10 , C07D413/06 , C07D413/10 , A61K31/496 , A61K31/5375
摘要： A compound of formula (I), having histone deacetylase 6 (HDAC6) inhibitory activity, wherein X, Q, N, R1, R2, L, and n are as described, isomers thereof, or pharmaceutically acceptable salts thereof, the use thereof for the preparation of therapeutic medicaments, pharmaceutical compositions comprising the same, a method of treating disease using the composition, and methods for preparing the novel compounds. The novel compounds according to the present invention have histone deacetylase 6 (HDAC6) inhibitory activity, and are effective for the prevention or treatment of HDAC6-associated diseases, including cancer, inflammatory diseases, autoimmune diseases, neurological diseases and neurodegenerative disorders.
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公开(公告)号：US20180273495A1
公开(公告)日：2018-09-27
申请号：US15763972
申请日：2016-10-11
发明人： Yuntae Kim , Chang Sik Lee , Jung Taek Oh , Hyeseung Song , Jin Choi , Jaeyoung Lee
IPC分类号： C07D271/10 , C07D413/04 , C07D413/14 , A61K31/4245
CPC分类号： C07D271/10 , A61K31/4245 , A61P1/00 , A61P3/00 , A61P5/00 , A61P9/00 , A61P11/00 , A61P17/00 , A61P21/00 , A61P25/00 , A61P27/02 , A61P31/00 , A61P35/00 , C07D413/04 , C07D413/14
摘要： The present disclosure relates to novel compounds having histone deacetylase 6 (HDAC6) inhibitory activity, stereoisomers thereof or pharmaceutically acceptable salts thereof, the use thereof for the preparation of therapeutic medicaments, pharmaceutical compositions containing the same, a method for treating diseases using the composition, and methods for preparing the novel compounds. The novel compounds, stereoisomers thereof or pharmaceutically acceptable salts thereof according to the present disclosure have histone deacetylase (HDAC) inhibitory activity and are effective for the prevention or treatment of HDAC6-mediated diseases, including infectious diseases; neoplasms; endocrine, nutritional and metabolic diseases; mental and behavioral disorders; neurological diseases; diseases of the eye and adnexa; cardiovascular diseases; respiratory diseases; digestive diseases; diseases of the skin and subcutaneous tissue; diseases of the musculoskeletal system and connective tissue; or congenital malformations, deformations and chromosomal abnormalities.
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公开(公告)号：US20210188831A1
公开(公告)日：2021-06-24
申请号：US17263333
申请日：2019-07-25
发明人： Chang Sik Lee , Jung Taek Oh , Hokeun Yun , Hyeseung Song , Hyunjin Michael Kim
IPC分类号： C07D413/14 , C07D413/04 , C07D417/14
摘要： The present invention relates to novel compounds having a histone deacetylase 6 (HDAC6) inhibitory activity, optical isomers thereof or pharmaceutically acceptable salts thereof, a pharmaceutical use thereof, and a method for preparing the same. According to the present invention, the novel compounds, optical isomers thereof or pharmaceutically acceptable salts thereof have the histone deacetylase 6 (HDAC6) inhibitory activity, and are effective in preventing or treating HDAC6-related diseases, comprising infectious diseases; neoplasm; internal secretion; nutritional and metabolic diseases; mental and behavioral disorders; neurological diseases; eye and ocular adnexal diseases; circulatory diseases; respiratory diseases; digestive diseases; skin and subcutaneous tissue diseases; musculoskeletal system and connective tissue diseases; and teratosis or deformities, and chromosomal aberration.
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公开(公告)号：US09650379B2
公开(公告)日：2017-05-16
申请号：US15103597
申请日：2014-12-12
发明人： Changsik Lee , Hyun-Mo Yang , Changkon Lee , Miseon Bae , Soyoung Kim , Youngil Choi , Nina Ha , Jaekwang Lee , Jungtaek Oh , Hyeseung Song , Ilhyang Kim , Daekyu Choi , Jaeki Min , Hyojin Lim , Daekwon Bae
IPC分类号： C07D471/06 , A61K31/437 , C07D471/04 , C07D519/00
CPC分类号： C07D471/04 , C07D519/00
摘要： The present invention relates to novel azaindole derivatives, and more particularly, to novel azaindole derivatives having histone deacetylase (HDAC) inhibitory activity, isomers thereof, pharmaceutically acceptable salts thereof, hydrates thereof or solvates thereof, the use thereof for the preparation of pharmaceutical compositions, pharmaceutical compositions containing the same, a method of treating disease using the pharmaceutical compositions, and methods for preparing the novel azaindole derivatives. The novel azaindole derivatives according to the present invention are selective histone deacetylase (HDAC) inhibitors, and may be used as agents for treating malignant tumor diseases, inflammatory diseases, rheumatoid arthritis, and neurodegenerative diseases.
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公开(公告)号：US11958844B2
公开(公告)日：2024-04-16
申请号：US17263333
申请日：2019-07-25
发明人： Chang Sik Lee , Jung Taek Oh , Hokeun Yun , Hyeseung Song , Hyunjin Michael Kim
IPC分类号： C07D413/14 , C07D413/04 , C07D417/14
CPC分类号： C07D413/14 , C07D413/04 , C07D417/14
摘要： The present invention relates to novel compounds having a histone deacetylase 6 (HDAC6) inhibitory activity, optical isomers thereof or pharmaceutically acceptable salts thereof, a pharmaceutical use thereof, and a method for preparing the same. According to the present invention, the novel compounds, optical isomers thereof or pharmaceutically acceptable salts thereof have the histone deacetylase 6 (HDAC6) inhibitory activity, and are effective in preventing or treating HDAC6-related diseases, comprising infectious diseases; neoplasm; internal secretion; nutritional and metabolic diseases; mental and behavioral disorders; neurological diseases; eye and ocular adnexal diseases; circulatory diseases; respiratory diseases; digestive diseases; skin and subcutaneous tissue diseases; musculoskeletal system and connective tissue diseases; and teratosis or deformities, and chromosomal aberration.
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公开(公告)号：US20230092890A1
公开(公告)日：2023-03-23
申请号：US17614967
申请日：2020-05-29
发明人： Chang Sik Lee , Jung Taek Oh , Hokeun Yun , Hyeseung Song , Hyunjin Michael Kim
IPC分类号： C07D413/14 , C07D417/14 , C07D491/107 , C07D471/04
摘要： The present invention relates to 1,3,4-oxadiazole derivative compounds having a histone deacetylase 6 (HDAC6) inhibitory activity, stereoisomers thereof or pharmaceutically acceptable salts thereof, a use thereof in preparation of a medicament, a pharmaceutical composition comprising the same, a therapeutic method using the composition, and a method for preparing the same, and the 1,3,4-oxadiazole derivative compounds are represented by a following chemical formula (I).
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公开(公告)号：US20180230114A1
公开(公告)日：2018-08-16
申请号：US15750067
申请日：2016-08-04
发明人： Jaekwang Lee , Yuntae Kim , Chang Sik Lee , Hyeseung Song , Dal-Yong Gwak , Jaeyoung Lee , Jung Taek Oh , Chang Gon Lee , Il Hyang Kim
IPC分类号： C07D271/10
摘要： The present invention relates to novel compounds having histone deacetylase 6 (HDAC6) in-hibitory activity, stereoisomers thereof or pharmaceutically acceptable salts thereof the use thereof for the preparation of therapeutic medicaments, pharmaceutical compositions containing the same, a method for treating diseases using the composition, and methods for preparing the novel compounds. The novel compounds stereoisomers thereof or pharmaceutically acceptable salts thereof according to the present invention have histone deacetylase (HDAC) inhibitory activity and are effective for the prevention or treatment of HDAC6-mediated diseases, including infectious diseases; neoplasms; endocrine, nutritional and metabolic diseases; mental and be-havioral disorders; neurological diseases; diseases of the eye and adnexa; cardiovascular diseases; respiratory diseases; digestive diseases; diseases of the skin and subcutaneous tissue; diseases of the musculoskeletal system and connective tissue; or congenital malformations, deformations and chromosomal abnormalities.
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9.发明公开公开(公告)号：US20240208956A1
公开(公告)日：2024-06-27
申请号：US18286037
申请日：2022-04-07
IPC分类号： C07D413/14 , A61K31/4245 , A61K31/438 , A61K31/4439 , A61K31/496 , A61K31/4995 , A61K31/5377 , C07D413/12 , C07D417/14 , C07D471/10 , C07D487/08 , C07D487/10 , C07D491/107
CPC分类号： C07D413/14 , A61K31/4245 , A61K31/438 , A61K31/4439 , A61K31/496 , A61K31/4995 , A61K31/5377 , C07D413/12 , C07D417/14 , C07D471/10 , C07D487/08 , C07D487/10 , C07D491/107
摘要： The present invention relates to a novel 1,3,4-oxadiazole thiocarbonyl compound having a histone deacetylase 6 (HDAC6) inhibitory activity, stereoisomers thereof, pharmaceutically acceptable salts thereof, a use thereof for preparing a medicament, a pharmaceutical composition containing the same, a therapeutic method using the composition, and a preparation method thereof, wherein a novel compound having a selective HDAC6 inhibitory activity is represented by formula I.
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10.发明公开公开(公告)号：US20230295142A1
公开(公告)日：2023-09-21
申请号：US18024081
申请日：2021-09-01
发明人： Chang Sik Lee , Jung Taek Oh , Hokeun Yun , Hyeseung Song , Hyunjin Michael Kim
IPC分类号： C07D413/14 , C07D413/10 , C07D487/10
CPC分类号： C07D413/14 , C07D413/10 , C07D487/10
摘要： The present invention relates to a novel compound having a selective HDAC6 inhibitory activity, stereoisomers thereof, pharmaceutically acceptable salts thereof, a use thereof in preparation of a therapeutic medicament, a pharmaceutical composition containing the same, a therapeutic method using the composition, and a method for preparing the same, wherein the novel compound having the selective HDAC6 inhibitory activity is represented by chemical formula (I) below.
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