-
公开(公告)号：US10981884B2
公开(公告)日：2021-04-20
申请号：US16087388
申请日：2017-03-21
发明人： Irén Hortobágyi , István Lászlófi , Zsuzsanna Kardos , József Molnár , László Takács , Róbertné Tormási
IPC分类号： C07D307/937 , A61K9/19
摘要： The invention provides a stable epoprostenol sodium and a process for the preparation this pharmaceutically active ingredient.
-
公开(公告)号：US11724979B2
公开(公告)日：2023-08-15
申请号：US17377125
申请日：2021-07-15
发明人： Imre Juhász , Irén Hortobágyi , Tamás Altsach , István Lászlófi , Ágnes Nagyné Borkó , Imre Rozsumberszki , Gábor Havasi , Zsuzsanna Kardos , Péter Buzder-Lantos
IPC分类号： C07C51/347 , C07C41/26 , C07C45/30 , C07C45/65 , C07C51/09 , C07C51/41 , C07C67/14 , C07C67/29 , C07C67/293 , C07C69/76 , C07C41/30 , C07C41/48 , C07C43/315 , C07C13/547 , C07C35/37 , C07C59/72
CPC分类号： C07C51/347 , C07C13/547 , C07C35/37 , C07C41/26 , C07C41/30 , C07C41/48 , C07C43/315 , C07C45/30 , C07C45/305 , C07C45/65 , C07C51/09 , C07C51/412 , C07C59/72 , C07C67/14 , C07C67/29 , C07C67/293 , C07C69/76 , C07C2603/14 , C07C45/305 , C07C49/84 , C07C45/30 , C07C49/84 , C07C45/65 , C07C49/755 , C07C51/09 , C07C59/70 , C07C41/48 , C07C43/315 , C07C67/14 , C07C69/76 , C07C67/29 , C07C69/76 , C07C67/293 , C07C69/76 , C07C51/412 , C07C59/70
摘要： Treprostinil is a synthetic prostacyclin derivative with thrombocyte aggregation inhibitory and vasodilatory activity. Treprostinil can be administered in subcutaneous, intravenous, inhalable, or oral forms. Disclosed is a method for the preparation of treprostinil of formula I and its amorphous form, anhydrate form, monohydrate form, and polyhydrate form salts with bases. In the disclosed method, the chiral center in the 3-hydroxyoctyl substituent is formed at the end of the synthesis, so that the method is robust and well scalable. Also disclosed are treprostinil intermediates and the preparation of the intermediates.
-
公开(公告)号：US10322990B2
公开(公告)日：2019-06-18
申请号：US15518096
申请日：2015-09-28
发明人： Imre Juhász , Irén Hortobágyi , Tamás Altsach , István Lászlófi , Ágnes Nagyné Borkó , Imre Rozsumberszki , Gábor Havasi , Zsuzsanna Kardos , Péter Buzder-Lantos
IPC分类号： C07C51/347 , C07C41/26 , C07C45/30 , C07C45/65 , C07C51/09 , C07C51/41 , C07C67/14 , C07C67/29 , C07C67/293 , C07C69/76 , C07C41/30 , C07C41/48 , C07C43/315 , C07C13/547 , C07C35/37 , C07C59/72
摘要： Treprostinil is a synthetic prostacyclin derivative with thrombocyte aggregation inhibitory and vasodilatory activity. Treprostinil can be administered in subcutaneous, intravenous, inhalable, or oral forms. Disclosed is a method for the preparation of treprostinil of formula I and its amorphous form, anydrate form, monohydrate form, and polyhydrate form salts with bases. In the disclosed method, the chiral center in the 3-hydroxyoctyl substituent is formed at the end of the synthesis, so that the method is robust and well scalable. Also disclosed are treprostinil intermediates and the preparation of the intermediates.
-
公开(公告)号：US11008594B2
公开(公告)日：2021-05-18
申请号：US16087402
申请日：2017-03-21
发明人： Irén Hortobágyi , István Lászlófi , Zsuzsanna Kardos , József Molnár , László Takács , Tamás Bán
摘要： The invention provides a new enzimatic process for the preparation of chiral carboxylic acids, their salts and acid derivatives of the general formula (I) by enzymatic hydrolysis of racemic carboxylic acid ester of the general formula (II) and optionally subsequent esterification or acylation.
-
公开(公告)号：US10421737B2
公开(公告)日：2019-09-24
申请号：US16091019
申请日：2017-03-30
发明人： Irén Hortobágyi , István Lászlófi , Zsuzsanna Kardos , József Molnár , László Takács , Tamás Bán
IPC分类号： C07D307/93
摘要： The invention provides a new process for the preparation of optically active Beraprost of formula (I) starting from racemic Beraprost alkyl ester through hydrolysis, enantiomer esterification, preparation of diacyl-Beraprost ester diastereomers and their separation and hydrolysis.
-
公开(公告)号：US11319274B2
公开(公告)日：2022-05-03
申请号：US16978391
申请日：2019-03-07
发明人： Irén Hortobágyi , István Lászlófi , Zoltán Varga , Imre Juhász , Imola Ritz , Zsuzsanna Kardos
IPC分类号： C07C51/43 , C07C59/72 , C07C215/10
摘要： The invention relates to a robust and reproducible process for the preparation of polymorph form B of treprostinil diethanolamine salt, comprising the following steps: a. treprostinil is dissolved in methanol, b. to the solution of step a) diethanolamine or its methanol solution is added, c. the reaction mixture of step b) is agitated till dissolution, d. when salt formation is completed in step c), first portion of an aprotic solvent is added to the solution, e. the solution of step d) is filtered to remove insoluble impurities, f. the filtrate of step e) is seeded with polymorph form B of treprostinil diethanolamine salt, g. to the crystal suspension obtained in step f) a second portion of the aprotic solvent is added, h. the suspension of step g) is agitated until crystallisation is completed, i. the crystals are separated, washed and dried.
-
公开(公告)号：US11098001B2
公开(公告)日：2021-08-24
申请号：US16397139
申请日：2019-04-29
发明人： Imre Juhász , Irén Hortobágyi , Tamás Altsach , István Lászlófi , Ágnes Nagyné Borkó , Imre Rozsumberszki , Gábor Havasi , Zsuzsanna Kardos , Péter Buzder-Lantos
IPC分类号： C07C51/347 , C07C41/26 , C07C45/30 , C07C45/65 , C07C51/09 , C07C51/41 , C07C67/14 , C07C67/29 , C07C67/293 , C07C69/76 , C07C41/30 , C07C41/48 , C07C43/315 , C07C13/547 , C07C35/37 , C07C59/72
摘要： Treprostinil is a synthetic prostacyclin derivative with thrombocyte aggregation inhibitory and vasodilatory activity. Treprostinil can be administered in subcutaneous, intravenous, inhalable, or oral forms. Disclosed is a method for the preparation of treprostinil of formula I and its amorphous form, anhydrate form, monohydrate form, and polyhydrate form salts with bases. In the disclosed method, the chiral center in the 3-hydroxyoctyl substituent is formed at the end of the synthesis, so that the method is robust and well scalable. Also disclosed are treprostinil intermediates and the preparation of the intermediates.
-
公开(公告)号：US10442762B2
公开(公告)日：2019-10-15
申请号：US15780896
申请日：2016-11-10
发明人： Péter Buzder-Lantos , Zsuzsanna Kardos , Irén Hortobágyi , István Lászlófi , Imre Juhász , László Fónagy , Csaba Váradi , Ágnes Nagyné Borkó
IPC分类号： C07C405/00 , B01D15/26 , B01D15/42 , B01J20/10 , C07C7/12
摘要： The subject of the invention is a novel process for the preparation of Carboprost tromethamine salt where alkylation the enone of the general formula (II) is carried out in the presence of a chiral auxiliary in aprotic solvent with a Grignard reagent. The methyl ester epimers of formula (VII) are separated by gravity silica gel chromatography and the salt formation is carried out by using solid tromethamine base.
-
-
-
-
-
-
-
搜索结果
8 条记录 (耗时 0.025 秒)
