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    Process for the purification of L-α-glycerophosphorylcholine
    2.
    发明授权
    Process for the purification of L-α-glycerophosphorylcholine 有权

    公开(公告)号：US10787469B2

    公开(公告)日：2020-09-29

    申请号：US16360052

    申请日：2019-03-21

    Applicant: Chemi S.P.A.

    Inventor： Lorenzo De Ferra ,  Mauro Anibaldi ,  Maurizio Zenoni ,  Fabrizio Cocchi

    IPC: C07F9/10 ,  C07F9/6574 ,  C07F9/09 ,  B01D15/08 ,  G01N21/49 ,  G01N30/02

    Abstract: A process for the purification of L-α-glycerophosphorylcholine is described, wherein L-α-glycerophosphorylcholine is crystallized from DMSO or from a mixture of DMSO with at least another solvent, preferably selected from water, alcohol, halogenated solvents, ethers, esters and/or amides. Such a process allows to obtain L-α-glycerophosphorylcholine having a purity greater than 99.5%, preferably greater than 99.7%, even more preferably greater than or equal to 99.9%. A method for determining the purity of L-α-glycerophosphorylcholine is also described, comprising the elution of L-α-glycerophosphorylcholine through an HPLC column having an amino stationary phase, and subsequent detection of L-α-glycerophosphorylcholine itself, and any impurity thereof, by means of an Evaporative Light Scattering Detector type.

    PROCESS FOR THE PREPARATION OF POLYSACCHARIDES
    4.
    发明申请
    PROCESS FOR THE PREPARATION OF POLYSACCHARIDES 审中-公开

    公开(公告)号：US20180134813A1

    公开(公告)日：2018-05-17

    申请号：US15570227

    申请日：2016-05-18

    Applicant: Chemi S.P.A.

    Inventor： Lorenzo De Ferra ,  Ettore Ammirati ,  Simona Andreassi ,  Mauro Annibaldi ,  Luca Mandelli ,  Barbara Pinto ,  Felice Stracqualursi

    IPC: C08B37/00 ,  C07H11/00 ,  A61K31/737

    Abstract: The present invention relates to a process for the preparation of a polysaccharide composed of D-xylose units of formula (III) linked together via beta 1,4 glycosidic bonds wherein R1 is hydrogen or acetyl, R2 is hydrogen, acetyl or a 4-O-methyl glucuronic acid unit, wherein, when R2 is a 4-O-methyl glucuronic acid unit, the R1 group on the same saccharide unit is defined as G, wherein G is hydrogen or acetyl, and wherein the sugar unit at the reducing end of sun such polysaccharide is xylose, lyxose or xylulose, said process comprising the following steps: selective deacetylation of xylan extracted from beech wood; and isomerization of the selectively deacetylated xylan achieved in step or the following steps: isomerization of xylan extracted from beech wood; and selective deacetylation of isomerized xylan achieved in step. The process is useful for the preparation of pentosan polysulfate or pharmaceutically acceptable salts thereof for pharmaceutical use.

    PROCESS FOR THE PURIFICATION OF L-ALPHA-GLYCEROPHOSPHORYLCHOLINE
    7.
    发明申请
    PROCESS FOR THE PURIFICATION OF L-ALPHA-GLYCEROPHOSPHORYLCHOLINE 审中-公开

    公开(公告)号：US20190218234A1

    公开(公告)日：2019-07-18

    申请号：US16360052

    申请日：2019-03-21

    Applicant: Chemi S.P.A.

    Inventor： Lorenzo De Ferra ,  Mauro Anibaldi ,  Maurizio Zenoni ,  Fabrizio Cocchi

    IPC: C07F9/10 ,  B01D15/08 ,  G01N21/49 ,  G01N30/02 ,  C07F9/6574 ,  C07F9/09

    Abstract: A process for the purification of L-α-glycerophosphorylcholine is described, wherein L-α-glycerophosphorylcholine is crystallized from DMSO or from a mixture of DMSO with at least another solvent, preferably selected from water, alcohol, halogenated solvents, ethers, esters and/or amides. Such a process allows to obtain L-α-glycerophosphorylcholine having a purity greater than 99.5%, preferably greater than 99.7%, even more preferably greater than or equal to 99.9%. A method for determining the purity of L-α-glycerophosphorylcholine is also described, comprising the elution of L-α-glycerophosphorylcholine through an HPLC column having an amino stationary phase, and subsequent detection of L-α-glycerophosphorylcholine itself, and any impurity thereof, by means of an Evaporative Light Scattering Detector type.

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