公开(公告)号：US12098174B2

公开(公告)日：2024-09-24

申请号：US17310517

申请日：2020-02-06

Applicant: CHA UNIVERSITY INDUSTRY-ACADEMIC COOPERATION FOUNDATION

Inventor： Kwang-Hyun Baek ,  Ji-Hye Choi

IPC: C07K14/47

CPC classification number: C07K14/4702

Abstract: The present invention provides an Oct-3/4 protein variant wherein lysine at position 156; lysine at position 286; or lysines at positions 156 and 286 in the Oct-3/4 protein is (are) substituted with arginine. The Oct-3/4 protein variant according to the present invention can inhibit a protein degradation mechanism through ubiquitination, and shows a higher half-life, compared to the wild-type Oct-3/4, thereby exhibiting high stability.