-
公开(公告)号:US12098174B2
公开(公告)日:2024-09-24
申请号:US17310517
申请日:2020-02-06
Inventor: Kwang-Hyun Baek , Ji-Hye Choi
IPC: C07K14/47
CPC classification number: C07K14/4702
Abstract: The present invention provides an Oct-3/4 protein variant wherein lysine at position 156; lysine at position 286; or lysines at positions 156 and 286 in the Oct-3/4 protein is (are) substituted with arginine. The Oct-3/4 protein variant according to the present invention can inhibit a protein degradation mechanism through ubiquitination, and shows a higher half-life, compared to the wild-type Oct-3/4, thereby exhibiting high stability.