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公开(公告)号：US20240043443A1
公开(公告)日：2024-02-08
申请号：US18228452
申请日：2023-07-31
申请人： CASE WESTERN RESERVE UNIVERSITY , BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM , UNIVERSITY OF KENTUCKY RESEARCH FOUNDATION
发明人： Sanford Markowitz , James K.V. Willson , Bruce Posner , Joseph Ready , Yongyou Zhang , Hsin-Hsiung Tai , Monica Antczak , Stanton Gerson , KiBeom Bae , Sung Yeun Yang , Amar Desai
IPC分类号： C07D495/04 , C07C311/21 , C07D213/71 , C07D213/73 , C07D213/75 , C07D213/76 , C07D215/08 , C07D237/20 , C07D405/12 , C07D239/42 , C07D241/20 , C07D261/14 , C07D207/263 , C07D275/03 , C07D209/08 , C07D277/46 , C07D295/185 , A61K31/4365 , A61K31/519
CPC分类号： C07D495/04 , C07C311/21 , C07D213/71 , C07D213/73 , C07D213/75 , C07D213/76 , C07D215/08 , C07D237/20 , C07D405/12 , C07D239/42 , C07D241/20 , C07D261/14 , C07D207/263 , C07D275/03 , C07D209/08 , C07D277/46 , C07D295/185 , A61K31/4365 , A61K31/519 , C07C2601/14
摘要： Compounds and methods of modulating 15-PGDH activity, modulating tissue prostaglandin levels, treating disease, diseases disorders, or conditions in which it is desired to modulate 15-PGDH activity and/or prostaglandin levels include 15-PGDH inhibitors and 15-PGDH activators described herein.
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2.发明申请公开(公告)号：US20180125829A1
公开(公告)日：2018-05-10
申请号：US15799307
申请日：2017-10-31
发明人： Sanford Markowitz , Amar Desai , Joseph Ready
IPC分类号： A61K31/4365 , A61K31/495 , A61K38/19
摘要： A method of modulating hematopoietic stem cells and hematopoiesis includes administering to a subject in need thereof a 15-PGDH inhibitor.
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公开(公告)号：US20170165241A1
公开(公告)日：2017-06-15
申请号：US15359330
申请日：2016-11-22
申请人： CASE WESTERN RESERVE UNIVERSITY , Board of Regents of the University of Texas System , University of Kentucky Research Foundation
发明人： Sanford Markowitz , James K.V. Willson , Bruce Posner , Joseph Ready , Youngyou Zhang , Hsin-Hsiung Tai , Melissa Moss , Monika Antczak , Stanton Gerson , KiBeom Bae , Sung Yeun Yang , Amar Desai
IPC分类号： A61K31/4365 , A61K31/519
CPC分类号： C07D495/04 , A61K31/4365 , A61K31/519 , C07C311/21 , C07C2601/14 , C07D207/263 , C07D209/08 , C07D213/71 , C07D213/73 , C07D213/75 , C07D213/76 , C07D215/08 , C07D237/20 , C07D239/42 , C07D241/20 , C07D261/14 , C07D275/03 , C07D277/46 , C07D295/185 , C07D405/12
摘要： Compounds and methods of modulating 15-PGDH activity, modulating tissue prostaglandin levels, treating disease, diseases disorders, or conditions in which it is desired to modulate 15-PGDH activity and/or prostaglandin levels include 15-PGDH inhibitors and 15-PGDH activators described herein.
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公开(公告)号：US20210106587A1
公开(公告)日：2021-04-15
申请号：US16997273
申请日：2020-08-19
发明人： Sanford Markowitz , James K.V. Willson , Bruce Posner , Joseph Ready , Monika Antczak , Yongyou Zhang , Amar Desai , Stanton Gerson , William Greenlee , Sung Yeun Yang , KiBeom Bae
IPC分类号： A61K31/5377 , C07D495/04 , A61K31/4365 , A61K31/437 , A61K31/444 , A61K31/496 , A61K31/519
摘要： Compounds and methods of modulating 15-PGDH activity, modulating tissue prostaglandin levels, treating disease, diseases disorders, or conditions in which it is desired to modulate 15-PGDH activity and/or prostaglandin levels include 15-PGDH inhibitors described herein.
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公开(公告)号：US10945998B2
公开(公告)日：2021-03-16
申请号：US15556972
申请日：2016-03-08
发明人： Sanford Markowitz , Stanton Gerson , Amar Desai , Won Jin Ho
IPC分类号： A61K31/44 , A61K31/4365 , C07D277/00 , A61K31/426 , C07D277/02
摘要： A method of treating or preventing a fibrotic disease, disorder or condition includes administering to a subject in need of treatment a 15-PGDH inhibitor.
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公开(公告)号：US09790233B2
公开(公告)日：2017-10-17
申请号：US14395021
申请日：2013-04-16
申请人： CASE WESTERN RESERVE UNIVERSITY , BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM , University of Kentucky Research Foundation
发明人： Sanford Markowitz , James K. V. Willson , Bruce A. Posner , Joseph Ready , Yongyou Zhang , Hsin-Hsiung Tai , Monika Antczak , Stanton Gerson , KiBeom Bae , Sung Yeun Yang , Amar Desai
IPC分类号： C07D495/04 , C07D213/71 , C07D213/73 , C07D213/75 , C07D213/76 , C07D215/08 , C07D237/20 , C07D405/12 , C07D239/42 , C07D241/20 , C07D261/14 , C07D207/263 , C07D275/03 , C07D209/08 , C07D277/46 , C07D295/185 , C07C311/21
CPC分类号： C07D495/04 , A61K31/4365 , A61K31/519 , C07C311/21 , C07C2601/14 , C07D207/263 , C07D209/08 , C07D213/71 , C07D213/73 , C07D213/75 , C07D213/76 , C07D215/08 , C07D237/20 , C07D239/42 , C07D241/20 , C07D261/14 , C07D275/03 , C07D277/46 , C07D295/185 , C07D405/12
摘要： Compounds and methods of modulating 15-PGDH activity, modulating tissue prostaglandin levels, treating disease, diseases disorders, or conditions in which it is desired to modulate 15-PGDH activity and/or prostaglandin levels include 15-PGDH inhibitors and 15-PGDH activators described herein.
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公开(公告)号：US20230192717A1
公开(公告)日：2023-06-22
申请号：US17926214
申请日：2021-05-19
申请人： RODEO THERAPEUTICS CORPORATION , Case Western Reserve University , Board of Regents of the University of Texas System
发明人： Stephen L Gwaltney , Joseph Ready , Monika Antczak , Sanford Markowitz , Amar Desai , Stanton Gerson
IPC分类号： C07D495/04 , A61K45/06 , C07D519/00
CPC分类号： C07D495/04 , A61K45/06 , C07D519/00
摘要： Compounds and methods of modulating 15-PGDH activity, modulating tissue prostaglandin levels, treating disease, diseases disorders, or conditions in which it is desired to modulate 15-PGDH activity and/or prostaglandin levels include 15-PGDH inhibitors described herein.
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公开(公告)号：US10301320B2
公开(公告)日：2019-05-28
申请号：US15359330
申请日：2016-11-22
申请人： CASE WESTERN RESERVE UNIVERSITY , Board of Regents of the University of Texas System , University of Kentucky Research Foundation
发明人： Sanford Markowitz , James K. V. Willson , Bruce Posner , Joseph Ready , Youngyou Zhang , Hsin-Hsiung Tai , Monika Antczak , Stanton Gerson , KiBeom Bae , Sung Yeun Yang , Amar Desai
IPC分类号： A61K31/4365 , C07D495/04 , C07D213/71 , C07D213/73 , C07D213/75 , C07D213/76 , C07D215/08 , C07D237/20 , C07D405/12 , C07D239/42 , C07D241/20 , C07D261/14 , C07D207/263 , C07D275/03 , C07D209/08 , C07D277/46 , C07D295/185 , C07C311/21 , A61K31/519
摘要： Compounds and methods of modulating 15-PGDH activity, modulating tissue prostaglandin levels, treating disease, diseases disorders, or conditions in which it is desired to modulate 15-PGDH activity and/or prostaglandin levels include 15-PGDH inhibitors and 15-PGDH activators described herein.
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公开(公告)号：US09789116B2
公开(公告)日：2017-10-17
申请号：US15029943
申请日：2014-10-15
发明人： Sanford Markowitz , James K. V. Willson , Bruce Posner , Joseph Ready , Monika Antczak , Yongyou Zhang , Amar Desai , Stanton Gerson , William Greenlee
IPC分类号： A61K31/535 , A61K31/5377 , A61K31/4365 , A61K31/519 , A61K31/437 , A61K31/444 , A61K31/496
CPC分类号： A61K31/5377 , A61K31/4365 , A61K31/437 , A61K31/444 , A61K31/496 , A61K31/519 , C07D495/04
摘要： Compounds and methods of modulating 15-PGDH activity, modulating tissue prostaglandin levels, treating disease, diseases disorders, or conditions in which it is desired to modulate 15-PGDH activity and/or prostaglandin levels include 15-PGDH inhibitors described herein.
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公开(公告)号：US20170173028A1
公开(公告)日：2017-06-22
申请号：US15029943
申请日：2014-10-15
发明人： Sanford Markowitz , James K.V. Willson , Bruce Posner , Joseph Ready , Monika Antczak , Youngyou Zhang , Amar Desai , Stanton Gerson , William Greenlee
IPC分类号： A61K31/5377 , A61K31/496 , A61K31/437 , A61K31/444 , A61K31/4365 , A61K31/519
CPC分类号： A61K31/5377 , A61K31/4365 , A61K31/437 , A61K31/444 , A61K31/496 , A61K31/519 , C07D495/04
摘要： Compounds and methods of modulating 15-PGDH activity, modulating tissue prostaglandin levels, treating disease, diseases disorders, or conditions in which it is desired to modulate 15-PGDH activity and/or prostaglandin levels include 15-PGDH inhibitors described herein.
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