- 专利标题： COMPOSITIONS AND METHODS OF MODULATING 15-PGDH ACTIVITY
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申请号： US18228452申请日： 2023-07-31
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公开(公告)号： US20240043443A1公开(公告)日： 2024-02-08
- 发明人: Sanford Markowitz , James K.V. Willson , Bruce Posner , Joseph Ready , Yongyou Zhang , Hsin-Hsiung Tai , Monica Antczak , Stanton Gerson , KiBeom Bae , Sung Yeun Yang , Amar Desai
- 申请人： CASE WESTERN RESERVE UNIVERSITY , BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM , UNIVERSITY OF KENTUCKY RESEARCH FOUNDATION
- 申请人地址： US OH Cleveland
- 专利权人： CASE WESTERN RESERVE UNIVERSITY,BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM,UNIVERSITY OF KENTUCKY RESEARCH FOUNDATION
- 当前专利权人： CASE WESTERN RESERVE UNIVERSITY,BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM,UNIVERSITY OF KENTUCKY RESEARCH FOUNDATION
- 当前专利权人地址： US OH Cleveland
- 主分类号： C07D495/04
- IPC分类号： C07D495/04 ; C07C311/21 ; C07D213/71 ; C07D213/73 ; C07D213/75 ; C07D213/76 ; C07D215/08 ; C07D237/20 ; C07D405/12 ; C07D239/42 ; C07D241/20 ; C07D261/14 ; C07D207/263 ; C07D275/03 ; C07D209/08 ; C07D277/46 ; C07D295/185 ; A61K31/4365 ; A61K31/519
摘要：
Compounds and methods of modulating 15-PGDH activity, modulating tissue prostaglandin levels, treating disease, diseases disorders, or conditions in which it is desired to modulate 15-PGDH activity and/or prostaglandin levels include 15-PGDH inhibitors and 15-PGDH activators described herein.
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