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公开(公告)号：US20230228656A1
公开(公告)日：2023-07-20
申请号：US18002526
申请日：2021-07-02
Applicant: CAPITAINER AB
Inventor： Olof BECK
CPC classification number: G01N1/38 , B01L3/50825 , G01N33/98 , B01L2200/16 , G01N2001/386
Abstract: A device configured for collection and subsequent testing of a blood sample of less than 10 ml, characterized in that the container includes at least one inhibitor of the enzyme phospholipase D selected from at least one of a salt of vanadium and a salt of tungsten. A method of preparing a sample for analysis of phosphatidylethanol (PEth) comprises providing a blood sample for a patient with a volume of less than 10 ml; contacting the blood sample at least one inhibitor of the enzyme phospholipase D selected from at least one of a salt of vanadium and a salt of tungsten; and admitting inhibition of phospholipase D so formation of PEth is blocked. A method of applying a coating of at least one inhibitor of the enzyme phospholipase D to a test tube and the test tube obtained by this method, wherein the method comprises stabilizing the test in a substantially vertical position; inserting a spray nozzle inside the test tube, the spray nozzle being in fluid connection to a container holding a solution comprising at least one inhibitor of the enzyme phospholipase D; spraying the solution comprising at least one inhibitor of the enzyme phospholipase D inside the test tube; and allowing the solution comprising at least one inhibitor of the enzyme phospholipase D to dry.
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公开(公告)号：US20230228654A1
公开(公告)日：2023-07-20
申请号：US18002537
申请日：2021-07-02
Applicant: CAPITAINER AB
Inventor： Olof BECK
CPC classification number: G01N1/34 , B01L3/50273 , B01L2300/0816 , B01L2300/126 , B01L2400/0406 , B01L2200/16
Abstract: A device configured to collect a blood sample comprising a capillary means, wherein the capillary means is configured to collect and dry the blood sample and comprises an effective amount of a distributed inhibitor of phospholipase D. The device may be configured to receive, transport and collect a blood sample comprising a compartment in fluid connection with the capillary means, wherein the capillary means is configured to collect and dry the blood sample and comprises an effective amount of a distributed PLD inhibitor. The device may be a microfluidic device comprising an inlet portion, an outlet portion comprising a capillary means configured to collect and dry the blood sample, and optionally a metering function, wherein the microfluidic device comprises an effective amount of a distributed PLD inhibitor. The PLD inhibitor is distributed in a water soluble film, preferably a PVA film, or in an absorbent paper or polymer or in the capillary means. The PLD inhibitor may be selected from a salt of a transition metal belonging to column 5 or 6 of the periodic table, a salt of vanadium and a salt of tungsten, a salt comprising a vanadium oxyanion and a salt comprising a tungsten oxyanion, and/or at least one of NaVO3 (sodium metavanadate) and Na2WO4 (sodium tungstate). A method of preparing a sample for analysis of phosphatidylethanol (PEth) comprises providing a blood sample with a volume of less than 10 ml to the device; contacting the blood sample with at least one inhibitor of the enzyme phospholipase D selected from at least one of a salt of vanadium and a salt of tungsten; and admitting inhibition of phospholipase D so formation of PEth is blocked.
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