公开(公告)号：US20240209407A1

公开(公告)日：2024-06-27

申请号：US18556773

申请日：2022-04-26

Applicant: CAMENA BIOSCIENCE LIMITED

Inventor： Derek STEMPLE ,  Sylwia MANKOWSKA ,  Neil BELL

IPC: C12P19/34 ,  C12N9/00 ,  C12N9/22 ,  C12N15/11

CPC classification number: C12P19/34 ,  C12N9/22 ,  C12N9/93 ,  C12N15/11 ,  C12Y605/01001 ,  C12N2310/16 ,  C12N2310/531

Abstract: Described herein are compositions of matter and methods to synthesize any nucleic acid (NA) sequence using completely natural nucleic acid sources without the need for large-scale phosphoramidite-mediated chemical synthesis.

公开(公告)号：US20240247256A1

公开(公告)日：2024-07-25

申请号：US18560445

申请日：2022-05-11

Applicant: CAMENA BIOSCIENCE LIMITED

Inventor： Derek L. STEMPLE ,  Steven HARVEY ,  Neil BELL ,  James ALLEN ,  Ellecia STARR ,  Nadin FATHALLAH

IPC: C12N15/11 ,  C12N9/22

CPC classification number: C12N15/11 ,  C12N9/22 ,  C12N2310/16

Abstract: Disclosed herein are compositions and methods that utilize high-throughput oligonucleotide synthesis methods, including array-based oligonucleotide synthesis, to generate the materials needed for the gSynth and Addamer based DNA synthesis methods. Accordingly, disclosed here are compositions and methods that combine gSynth and Addamer technologies with high-throughput oligonucleotide synthesis to generate routine high-fidelity gene (target nucleic acid) synthesis.

公开(公告)号：US20230407370A1

公开(公告)日：2023-12-21

申请号：US18253864

申请日：2021-11-22

Applicant: CAMENA BIOSCIENCE LIMITED

Inventor： Neil BELL

IPC: C12Q1/6806 ,  C12Q1/6869

CPC classification number: C12Q1/6806 ,  C12Q1/6869

Abstract: The present disclosure provides compositions, kits and methods for sequencing double-stranded nucleic acids. The compositions, kits and methods comprise partially double-stranded identifier molecules and partially double-stranded adapter molecules. The compositions, kits and methods can be used to determine the abundance and/or identity of specific transcripts in a plurality of double-stranded nucleic acids, as well as identifying the frequency of mutations within certain transcripts in the plurality of double-stranded nucleic acids.

公开(公告)号：US20220145346A1

公开(公告)日：2022-05-12

申请号：US17422967

申请日：2020-01-13

Applicant: CAMENA BIOSCIENCE LIMITED

Inventor： Derek L. STEMPLE ,  Andrew G. FRASER ,  Sylwia MANKOWSKA ,  Neil BELL

IPC: C12P19/34 ,  C07H21/00

Abstract: Disclosed are compositions and methods for template-free nucleic acid synthesis using N-mers and/or anchor primers that comprise at least one XNA or a combination of RNA and DNA.

公开(公告)号：US20220340964A1

公开(公告)日：2022-10-27

申请号：US17761696

申请日：2020-09-21

Applicant: Derek STEMPLE ,  CAMENA BIOSCIENCE LIMITED

Inventor： Derek STEMPLE ,  Neil BELL ,  Sylwia MANKOWSKA ,  Steven HARVEY ,  Andrew FRASER

IPC: C12Q1/6855 ,  C12Q1/6874 ,  C12N15/10

Abstract: The present disclosure provides compositions and methods for template-free double stranded geometric enzymatic nucleic acid synthesis of arbitrarily programmed nucleic acid sequences.

公开(公告)号：US20210087600A1

公开(公告)日：2021-03-25

申请号：US16961465

申请日：2019-01-14

Applicant: CAMENA BIOSCIENCE LIMITED

Inventor： Derek L. STEMPLE ,  Andrew G. FRASER ,  Sylwia MANKOWSKA ,  Neil BELL

IPC: C12P19/34 ,  C12N15/115

Abstract: Disclosed are compositions and methods for template-free nucleic acid synthesis.