公开(公告)号：US09580451B2

公开(公告)日：2017-02-28

申请号：US14604917

申请日：2015-01-26

Applicant: California Institute of Technology ,  Children's Hospital of Los Angeles

Inventor： Carl M. Blumenfeld ,  Harry B. Gray ,  Robert H. Grubbs ,  Karn Sorasaenee

IPC: C07F7/28 ,  C07D487/22 ,  C07F5/00 ,  C07F5/06 ,  A61K49/00

CPC classification number: C07F7/28 ,  A61K49/0021 ,  A61K49/0065 ,  A61K49/0067 ,  B01J2531/025 ,  C07D487/22 ,  C07F5/003 ,  C07F5/069

Abstract: The present invention is directed to sulfonic esters of metal oxides including those of formulas I and II:

Abstract translation: 本发明涉及包括式I和II的金属氧化物的磺酸酯：

公开(公告)号：US20140227187A1

公开(公告)日：2014-08-14

申请号：US14178592

申请日：2014-02-12

Applicant: Children's Hospital Of Los Angeles ,  California Institute of Technology

Inventor： Carl M. Blumenfeld ,  Harry B. Gray ,  Robert H. Grubbs ,  Karn Sorasaenee

IPC: C07F7/28 ,  A61K49/00

CPC classification number: C07F7/28 ,  A61K49/0021 ,  A61K49/0065 ,  A61K49/0067 ,  B01J2531/025 ,  C07D487/22 ,  C07F5/003 ,  C07F5/069

Abstract: The present invention is directed to sulfonic esters of metal oxides including those of formulas I and II:

Abstract translation: 本发明涉及包括式I和II的金属氧化物的磺酸酯：

公开(公告)号：US10646505B2

公开(公告)日：2020-05-12

申请号：US15696474

申请日：2017-09-06

Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGY

Inventor： Michael D. Schulz ,  Carl M. Blumenfeld ,  Robert H. Grubbs ,  Julia R. Greer ,  Daryl Wei Liang Yee

IPC: A61K31/711 ,  C08F222/10 ,  A61L29/08 ,  A61L31/16 ,  A61L29/16 ,  A61K47/58 ,  A61K47/69 ,  A61K47/54 ,  A61L31/08 ,  A61L31/10 ,  A61L31/14 ,  C08F293/00

Abstract: This disclosure is directed to structured compositions, including DNA-functionalized scaffolds, for drug capture, and methods and devices for sequestering chemotherapeutics from physiological fluids using the functionalized scaffolds.

公开(公告)号：US20150141640A1

公开(公告)日：2015-05-21

申请号：US14604917

申请日：2015-01-26

Applicant: California Institute of Technology ,  Children's Hospital Of Los Angeles

Inventor： Carl M. Blumenfeld ,  Harry B. Gray ,  Robert H. Grubbs ,  Karn Sorasaenee

IPC: C07F7/28

CPC classification number: C07F7/28 ,  A61K49/0021 ,  A61K49/0065 ,  A61K49/0067 ,  B01J2531/025 ,  C07D487/22 ,  C07F5/003 ,  C07F5/069

Abstract: The present invention is directed to sulfonic esters of metal oxides including those of formulas I and II:

Abstract translation: 本发明涉及包括式I和II的金属氧化物的磺酸酯：

公开(公告)号：US09636428B2

公开(公告)日：2017-05-02

申请号：US14492324

申请日：2014-09-22

Applicant: California Institute of Technology ,  Children's Hospital Los Angeles

Inventor： Carl M. Blumenfeld ,  Karn Sorasaenee ,  Harry B. Gray ,  Robert H. Grubbs

IPC: A61B5/055 ,  A61K49/16 ,  A61K49/10 ,  A61K47/48 ,  A61K49/00

CPC classification number: A61K49/16 ,  A61K47/557 ,  A61K49/00 ,  A61K49/0052 ,  A61K49/0058

Abstract: The present disclosure is directed to sulfonic esters of metal oxides including those of formulas I and II:

公开(公告)号：US20150202331A1

公开(公告)日：2015-07-23

申请号：US14492324

申请日：2014-09-22

Applicant: California Institute of Technology ,  Children's Hospital Los Angeles

Inventor： Carl M. Blumenfeld ,  Karn Sorasaenee ,  Harry B. Gray ,  Robert H. Grubbs

IPC: A61K49/16 ,  A61K49/10 ,  A61K49/00

CPC classification number: A61K49/16 ,  A61K47/557 ,  A61K49/00 ,  A61K49/0052 ,  A61K49/0058

Abstract: The present disclosure is directed to sulfonic esters of metal oxides including those of formulas I and II:

Abstract translation: 本公开涉及包括式I和II的金属氧化物的磺酸酯：

公开(公告)号：US08968789B2

公开(公告)日：2015-03-03

申请号：US14178592

申请日：2014-02-12

Applicant: California Institute of Technology ,  Children's Hospital of Los Angeles

Inventor： Carl M. Blumenfeld ,  Harry B. Gray ,  Robert H. Grubbs ,  Karn Sorasaenee

IPC: A61K49/08 ,  C07D487/22 ,  C07F5/00 ,  C07F5/06 ,  A61K49/00

CPC classification number: C07F7/28 ,  A61K49/0021 ,  A61K49/0065 ,  A61K49/0067 ,  B01J2531/025 ,  C07D487/22 ,  C07F5/003 ,  C07F5/069

Abstract: The present invention is directed to sulfonic esters of metal oxides including those of formulas I and II:

Abstract translation: 本发明涉及包括式I和II的金属氧化物的磺酸酯：