公开(公告)号：US20070270363A1

公开(公告)日：2007-11-22

申请号：US11502008

申请日：2006-08-09

申请人： C. Bennett ,  David Ecker ,  Timothy Vickers ,  Jacqueline Wyatt

发明人： C. Bennett ,  David Ecker ,  Timothy Vickers ,  Jacqueline Wyatt

IPC分类号： A61K48/00

CPC分类号： A61K31/70 ,  A61K38/00 ,  C07H21/00 ,  C12N15/1133 ,  C12N15/1137 ,  C12N15/115 ,  C12N15/117 ,  C12N2310/151 ,  C12N2310/18 ,  C12N2310/315 ,  C12N2310/321 ,  C12N2310/341 ,  C12N2310/346 ,  C12Q1/701 ,  C12Y207/07049 ,  C12Y301/01004 ,  C12N2310/3521

摘要： Modified oligonucleotides having a GGG motif sequence and a sufficient number of flanking nucleotides to modulate the telomere length of a chromosome are provided. Methods of modulating telomere length of a mammalian chromosome in vitro and in vivo are also provided, as are methods for inhibiting the division of a malignant mammalian cell and for modulating the effects of cellular aging.

摘要翻译： 提供了具有GGG基序序列和足够数目的侧翼核苷酸以调节染色体端粒长度的修饰寡核苷酸。 还提供了在体外和体内调节哺乳动物染色体的端粒长度的方法，以及抑制恶性哺乳动物细胞分裂和调节细胞衰老作用的方法。

公开(公告)号：US20070015723A1

公开(公告)日：2007-01-18

申请号：US11436901

申请日：2006-05-17

申请人： Ronnie Hanecak ,  Kevin Anderson ,  C. Bennett ,  Ming-Yi Chiang ,  Vickie Brown-Driver ,  David Ecker ,  Timothy Vickers ,  Jacqueline Wyatt

发明人： Ronnie Hanecak ,  Kevin Anderson ,  C. Bennett ,  Ming-Yi Chiang ,  Vickie Brown-Driver ,  David Ecker ,  Timothy Vickers ,  Jacqueline Wyatt

IPC分类号： A61K48/00

CPC分类号： A61K31/70 ,  A61K38/00 ,  C07H21/00 ,  C12N15/1133 ,  C12N15/1137 ,  C12N15/115 ,  C12N15/117 ,  C12N2310/151 ,  C12N2310/18 ,  C12N2310/315 ,  C12N2310/321 ,  C12N2310/341 ,  C12N2310/346 ,  C12Q1/701 ,  C12Y207/07049 ,  C12Y301/01004 ,  C12N2310/3521

摘要： Modified oligonucleotides having a conserved G4 sequence and a sufficient number of flanking nucleotides to significantly inhibit the activity of a virus or phospholipase A2 or to modulate the telomere length of a chromosome are provided. G4 quartet oligonucleotide structures are also provided. Methods of prophylaxis, diagnostics and therapeutics for viral-associated diseases and diseases associated with elevated levels of phospholipase A2 are also provided. Methods of modulating telomere length of a chromosome are also provided; modulation of telomere length is believed to play a role in the aging process of a cell and in control of malignant cell growth.

摘要翻译： 修饰的寡核苷酸具有保守的GAT4序列和足够数量的侧翼核苷酸以显着抑制病毒或磷脂酶A 2的活性或调节染色体的端粒长度 被提供。 还提供了G 4四重寡核苷酸结构。 还提供了与升高的磷脂酶A 2 2水平相关的病毒相关疾病和疾病的预防，诊断和治疗方法。 还提供了调节染色体端粒长度的方法; 相信端粒长度的调节在细胞的衰老过程中和恶性细胞生长的控制中起作用。

公开(公告)号：US20050261228A1

公开(公告)日：2005-11-24

申请号：US11089191

申请日：2005-03-23

申请人： C. Bennett ,  Brenda Baker ,  Susan Freier ,  Susan Gregory ,  Ronnie Hanecak ,  Kevin Anderson ,  Ming-Yi Chiang ,  Vickie Brown-Driver ,  David Ecker ,  Timothy Vickers ,  Jacqueline Wyatt ,  Eric Marcusson ,  Nicholas Dean ,  Sanjay Bhanot ,  Elizabeth Ackermann ,  Lex Cowsert

发明人： C. Bennett ,  Brenda Baker ,  Susan Freier ,  Susan Gregory ,  Ronnie Hanecak ,  Kevin Anderson ,  Ming-Yi Chiang ,  Vickie Brown-Driver ,  David Ecker ,  Timothy Vickers ,  Jacqueline Wyatt ,  Eric Marcusson ,  Nicholas Dean ,  Sanjay Bhanot ,  Elizabeth Ackermann ,  Lex Cowsert

IPC分类号： A61K38/00 ,  A61K48/00 ,  C07H21/04 ,  C12N15/113 ,  C12N15/85

CPC分类号： C12N15/1136 ,  A61K38/00 ,  C12N2310/315 ,  C12N2310/321 ,  C12N2310/3341 ,  C12N2310/341 ,  C12N2310/346 ,  Y02P20/582 ,  C12N2310/3525

摘要： Compounds, compositions and methods are provided for modulating the expression of Interleukin 12 p35 subunit. The compositions comprise chemically modified antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding Interleukin 12 p35 subunit. Methods of using these compounds for modulation of Interleukin 12 p35 subunit expression and for treatment of diseases associated with expression of Interleukin 12 p35 subunit are provided.

摘要翻译： 提供化合物，组合物和方法用于调节白细胞介素12p35亚基的表达。 组合物包含靶向编码白细胞介素12p35亚基的核酸的化学修饰的反义化合物，特别是反义寡核苷酸。 提供了使用这些化合物调节白介素12p35亚基表达和治疗与白细胞介素12p35亚基表达相关的疾病的方法。

公开(公告)号：US20060160758A1

公开(公告)日：2006-07-20

申请号：US11039632

申请日：2005-01-20

申请人： C. Bennett ,  Susan Freier ,  Brenda Baker ,  Brett Monia ,  Nicholas Dean ,  Hong Zhang ,  Susan Murray ,  Lex Cowsert ,  Madeline Butler ,  Robert McKay ,  Donna Ward ,  William Gaarde ,  Ian Popoff ,  Jacqueline Wyatt ,  Andrew Watt

发明人： C. Bennett ,  Susan Freier ,  Brenda Baker ,  Brett Monia ,  Nicholas Dean ,  Hong Zhang ,  Susan Murray ,  Lex Cowsert ,  Madeline Butler ,  Robert McKay ,  Donna Ward ,  William Gaarde ,  Ian Popoff ,  Jacqueline Wyatt ,  Andrew Watt

IPC分类号： A61K48/00 ,  C07H21/02

CPC分类号： C12N15/1138 ,  C12N2310/11 ,  C12N2310/315 ,  C12N2310/321 ,  C12N2310/3341 ,  C12N2310/341 ,  C12N2310/346 ,  Y02P20/582 ,  C12N2310/3525

摘要： Antisense compounds, compositions and methods are provided for modulating the expression of CD40 ligand. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding CD40 ligand. Methods of using these compounds for modulation of CD40 ligand expression and for treatment of diseases associated with expression of CD40 ligand are provided.

公开(公告)号：US20060154885A1

公开(公告)日：2006-07-13

申请号：US11072846

申请日：2005-03-04

申请人： C. Bennett ,  Brett Monia ,  Nicholas Dean ,  Xiaoxing Xu ,  Sanjay Bhanot ,  Brenda Baker ,  Susan Freier ,  Lex Cowsert ,  Robert McKay ,  Muthiah Manoharan ,  F. Dorr ,  Jon Holmlund ,  Alexander Borchers ,  Vickie Brown-Driver ,  Jacqueline Wyatt ,  Shin Flournoy ,  Elizabeth Ackermann ,  Hong Zhang ,  Andrew Watt ,  Eric Maracusson ,  Scott Cooper ,  Erich Koller ,  Loren Miraglia ,  William Ricketts ,  Kenneth Dobie ,  Tamara Sipes

发明人： C. Bennett ,  Brett Monia ,  Nicholas Dean ,  Xiaoxing Xu ,  Sanjay Bhanot ,  Brenda Baker ,  Susan Freier ,  Lex Cowsert ,  Robert McKay ,  Muthiah Manoharan ,  F. Dorr ,  Jon Holmlund ,  Alexander Borchers ,  Vickie Brown-Driver ,  Jacqueline Wyatt ,  Shin Flournoy ,  Elizabeth Ackermann ,  Hong Zhang ,  Andrew Watt ,  Eric Maracusson ,  Scott Cooper ,  Erich Koller ,  Loren Miraglia ,  William Ricketts ,  Kenneth Dobie ,  Tamara Sipes

IPC分类号： A61K48/00 ,  C07H21/02

CPC分类号： C12N15/1138 ,  A61K48/00 ,  C12N2310/11 ,  C12N2310/315 ,  C12N2310/321 ,  C12N2310/3341 ,  C12N2310/341 ,  C12N2310/346 ,  C12N2310/3525

摘要： Compounds, compositions and methods are provided for modulating the expression of SLC26A2. The compositions comprise oligonucleotides, targeted to nucleic acid encoding SLC26A2. Methods of using these compounds for modulation of SLC26A2 expression and for diagnosis and treatment of disease associated with expression of SLC26A2 are provided.

摘要翻译： 提供化合物，组合物和方法用于调节SLC26A2的表达。 组合物包含针对编码SLC26A2的核酸的寡核苷酸。 提供了使用这些化合物调节SLC26A2表达和用于诊断和治疗与SLC26A2表达相关的疾病的方法。

公开(公告)号：US20050227938A1

公开(公告)日：2005-10-13

申请号：US11015193

申请日：2004-12-17

申请人： C. Bennett ,  Brenda Baker ,  Nicholas Dean ,  Brett Monia ,  Susan Freier ,  James Karras ,  Hong Zhang ,  Susan Murray ,  Madeline Butler ,  Erich Koller ,  Thomas Condon ,  William Gaarde ,  Andrew Watt ,  Mark Graham ,  Jacqueline Wyatt ,  Lex Cowsert ,  Kenneth Dobie ,  Mark Roach

发明人： C. Bennett ,  Brenda Baker ,  Nicholas Dean ,  Brett Monia ,  Susan Freier ,  James Karras ,  Hong Zhang ,  Susan Murray ,  Madeline Butler ,  Erich Koller ,  Thomas Condon ,  William Gaarde ,  Andrew Watt ,  Mark Graham ,  Jacqueline Wyatt ,  Lex Cowsert ,  Kenneth Dobie ,  Mark Roach

IPC分类号： A61K38/00 ,  A61K48/00 ,  C07H21/02 ,  C12N15/113

CPC分类号： C12N15/1138 ,  A61K38/00 ,  C12N2310/315 ,  C12N2310/321 ,  C12N2310/322 ,  C12N2310/335 ,  C12N2310/341 ,  C12N2310/346 ,  Y02P20/582 ,  C12N2310/3521 ,  C12N2310/3525

摘要： Antisense compounds, compositions and methods are provided for modulating the expression of TFAP2C. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding TFAP2C. Methods of using these compounds for modulation of TFAP2C expression and for treatment of diseases associated with expression of TFAP2C are provided.

摘要翻译： 提供反义化合物，组合物和方法用于调节TFAP2C的表达。 组合物包含靶向编码TFAP2C的核酸的反义化合物，特别是反义寡核苷酸。 提供了使用这些化合物调节TFAP2C表达和治疗与TFAP2C表达相关的疾病的方法。

公开(公告)号：US20050267063A1

公开(公告)日：2005-12-01

申请号：US11117013

申请日：2005-04-27

申请人： C. Bennett ,  Brett Monia ,  Susan Freier ,  Brenda Baker ,  William Gaarde ,  Erich Koller ,  Susan Murray ,  Andrew Watt ,  Jacqueline Wyatt ,  Pamela Nero ,  Mark Roach ,  Lex Cowsert ,  Kenneth Dobie

发明人： C. Bennett ,  Brett Monia ,  Susan Freier ,  Brenda Baker ,  William Gaarde ,  Erich Koller ,  Susan Murray ,  Andrew Watt ,  Jacqueline Wyatt ,  Pamela Nero ,  Mark Roach ,  Lex Cowsert ,  Kenneth Dobie

IPC分类号： A61K38/00 ,  A61K48/00 ,  C07H21/04 ,  C12N5/02 ,  C12N15/113 ,  C12N15/85

CPC分类号： C12N15/1137 ,  A61K38/00 ,  B23Q2011/0808 ,  C12N2310/315 ,  C12N2310/321 ,  C12N2310/3341 ,  C12N2310/341 ,  C12N2310/346 ,  Y02P20/582 ,  C12N2310/3525

摘要： Antisense compounds, compositions and methods are provided for modulating the expression of p70 S6 kinase. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding p70 S6 kinase. Methods of using these compounds for modulation of p70 S6 kinase expression and for treatment of diseases associated with expression of p70 S6 kinase are provided.

摘要翻译： 提供反义化合物，组合物和方法用于调节p70 S6激酶的表达。 组合物包含靶向编码p70 S6激酶的核酸的反义化合物，特别是反义寡核苷酸。 提供了使用这些化合物调节p70 S6激酶表达和治疗与p70 S6激酶表达相关的疾病的方法。

公开(公告)号：US20050143331A1

公开(公告)日：2005-06-30

申请号：US10643038

申请日：2003-08-18

申请人： C. Bennett ,  Jacqueline Wyatt

发明人： C. Bennett ,  Jacqueline Wyatt

IPC分类号： A61K38/00 ,  C12N15/113 ,  A61K48/00 ,  C07H21/02 ,  C12Q1/68

CPC分类号： C12N15/1137 ,  A61K38/00 ,  C12N2310/315 ,  C12N2310/321 ,  C12N2310/3341 ,  C12N2310/341 ,  C12N2310/346 ,  C12Y301/01004 ,  Y02P20/582 ,  C12N2310/3525

摘要： Antisense compounds, compositions and methods are provided for modulating the expression of Phospholipase A2, group IIA (synovial). The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding Phospholipase A2, group IIA (synovial). Methods of using these compounds for modulation of Phospholipase A2, group IIA (synovial) expression and for treatment of diseases associated with expression of Phospholipase A2, group IIA (synovial) are provided.

摘要翻译： 提供反义化合物，组合物和方法用于调节磷脂酶A2（组IIA）（滑膜）的表达。 组合物包含靶向编码磷脂酶A2，组IIA（滑液）的核酸的反义化合物，特别是反义寡核苷酸。 提供了使用这些化合物调节磷脂酶A2，组IIA（滑液）表达和治疗与磷脂酶A2，组IIA（滑液）表达相关的疾病的方法。

公开(公告)号：US20060019920A1

公开(公告)日：2006-01-26

申请号：US11179128

申请日：2005-07-11

申请人： C. Bennett ,  Susan Freier ,  Brett Monia ,  Nicholas Dean ,  Hong Zhang ,  Robert McKay ,  Donna Ward ,  William Gaarde ,  Jacqueline Wyatt ,  Andrew Watt ,  Rosanne Crooke ,  Mark Graham ,  Pamela Nero ,  Kenneth Dobie ,  Alexander Borchers ,  Eric Marcusson ,  Mark Roach

发明人： C. Bennett ,  Susan Freier ,  Brett Monia ,  Nicholas Dean ,  Hong Zhang ,  Robert McKay ,  Donna Ward ,  William Gaarde ,  Jacqueline Wyatt ,  Andrew Watt ,  Rosanne Crooke ,  Mark Graham ,  Pamela Nero ,  Kenneth Dobie ,  Alexander Borchers ,  Eric Marcusson ,  Mark Roach

IPC分类号： A61K48/00 ,  C07H21/02

CPC分类号： C12N9/1205 ,  Y02P20/582

摘要： Antisense compounds, compositions and methods are provided for modulating the expression of MEKK4. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding MEKK4. Methods of using these compounds for modulation of MEKK4 expression and for treatment of diseases associated with expression of MEKK4 are provided.

公开(公告)号：US20050215504A1

公开(公告)日：2005-09-29

申请号：US11014360

申请日：2004-12-16

申请人： C. Bennett ,  Susan Freier ,  Nicholas Dean ,  Brett Monia ,  William Gaarde ,  James Karras ,  Hong Zhang ,  Robert McKay ,  Donna Ward ,  Lex Cowsert ,  Erich Koller ,  Jacqueline Wyatt ,  Mark Roach ,  Andrew Watt ,  Brenda Baker ,  Kenneth Dobie

发明人： C. Bennett ,  Susan Freier ,  Nicholas Dean ,  Brett Monia ,  William Gaarde ,  James Karras ,  Hong Zhang ,  Robert McKay ,  Donna Ward ,  Lex Cowsert ,  Erich Koller ,  Jacqueline Wyatt ,  Mark Roach ,  Andrew Watt ,  Brenda Baker ,  Kenneth Dobie

IPC分类号： A61K48/00 ,  C07H21/02 ,  C12N15/113 ,  C12Q1/68

CPC分类号： C12N15/113 ,  C12N2310/11 ,  C12N2310/315 ,  C12N2310/321 ,  C12N2310/3341 ,  C12N2310/341 ,  C12N2310/346 ,  Y02P20/582 ,  C12N2310/3525

摘要： Antisense compounds, compositions and methods are provided for modulating the expression of sterol regulatory element-binding protein-1. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding sterol regulatory element-binding protein-1. Methods of using these compounds for modulation of sterol regulatory element-binding protein-1 expression and for treatment of diseases associated with expression of sterol regulatory element-binding protein-1 are provided.

摘要翻译： 提供反义化合物，组合物和方法用于调节甾醇调节元件结合蛋白-1的表达。 组合物包含靶向编码固醇调节元件结合蛋白-1的核酸的反义化合物，特别是反义寡核苷酸。 提供了使用这些化合物调节固醇调节元件结合蛋白-1表达和治疗与甾醇调节元件结合蛋白-1的表达相关的疾病的方法。