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公开(公告)号：US09556179B2
公开(公告)日：2017-01-31
申请号：US14653895
申请日：2013-12-20
发明人： Upender Velaparthi , Chetan Padmakar Darne , Dharmpal S. Dodd , Anthony J. Sampognaro , Mark D. Wittman , Selvakumar Kumaravel , Dibakar Mullick , Peiying Liu , Chandrasekhar Reddy Rachamreddy
IPC分类号： C07D487/04 , C07D519/00
CPC分类号： C07D487/04 , C07D519/00
摘要： The invention provides compounds of Formula (I) and pharmaceutically acceptable salts thereof. The compounds of Formula (I) inhibit protein kinase activity thereby making them useful as anticancer agents.
摘要翻译： 本发明提供式（I）化合物及其药学上可接受的盐。 式（I）的化合物抑制蛋白激酶活性，从而使它们用作抗癌剂。
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公开(公告)号：US20230348426A1
公开(公告)日：2023-11-02
申请号：US18004731
申请日：2021-07-08
发明人： Pravin Sudhakar Shirude , Chandrasekhar Reddy Rachamreddy , Amit Kumar Chattopadhyay , Balaji Seshadri , Vishweshwaraiah Baligar , Sudhakara Reddy Madduri , Ellen K. Kick , Nicholas R. Wurtz
IPC分类号： C07D401/14 , C07D401/04 , C07D207/14 , C07F9/6558 , C07D487/08 , C07D413/14 , C07D405/14 , C07D491/107 , C07D491/08 , C07D403/04 , C07D487/04 , C07D471/04 , C07D498/04 , C07F9/572
CPC分类号： C07D401/14 , C07D207/14 , C07D401/04 , C07D403/04 , C07D405/14 , C07D413/14 , C07D471/04 , C07D487/04 , C07D487/08 , C07D491/08 , C07D491/107 , C07D498/04 , C07F9/572 , C07F9/65583
摘要： The disclosure relates to compounds of Formula (I), which are formyl peptide 2 (FPR2) receptor agonists and/or formyl peptide 1 (FPR1) receptor agonists. The disclosure also provides compositions and methods of using the compounds, for example, for the treatment of atherosclerosis, heart failure, chronic obstructive pulmonary disease (COPD), and related diseases.
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![Substituted 4,5,6,7-tetrahydropyrazolo[1,5-A]pyrazine derivatives as casein kinase 1 D/E inhibitors](/abs-image/US/2017/03/21/US09598423B2/abs.jpg.150x150.jpg)
3.发明授权公开(公告)号：US09598423B2
公开(公告)日：2017-03-21
申请号：US15034217
申请日：2014-11-14
发明人： Upender Velaparthi , Chetan Padmakar Darne , Peiying Liu , Mark D. Wittman , Bradley C. Pearce , Erika M. V. Araujo , Bireshwar Dasgupta , Jalathi Surendran Nair , Sakthi Kumaran Janakiraman , Chandrasekhar Reddy Rachamreddy , Mallikarjuna Rao Mettu , Arul Mozhi Selvan Subbiah Karuppiah , Bandreddy Subba Reddy , Pulicharla Nagalakshmi , Rajesh Onkardas Bora , Shilpa Holehatti Maheshwarappa , Selvakumar Kumaravel , Dibakar Mullick , Ramesh Sistla
IPC分类号： A61K31/498 , C07D487/04 , C07D491/147 , C07D487/10 , C07D491/20 , C07D487/20 , C07D519/00
CPC分类号： C07D487/04 , C07D487/10 , C07D487/20 , C07D491/147 , C07D491/20 , C07D519/00
摘要： The invention provides compounds of Formula (I): and pharmaceutically acceptable salts thereof. The compounds of Formula (I) inhibit protein kinase activity thereby making them useful as anticancer agents.
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公开(公告)号：US20230303513A1
公开(公告)日：2023-09-28
申请号：US18040831
申请日：2021-08-11
发明人： Pravin Sudhakar Shirude , Chandrasekhar Reddy Rachamreddy , Vishweshwaraiah Baligar , Balaji Seshadri , Sudhakara Reddy Madduri , Ellen K. Kick , Nicholas R. Wurtz
IPC分类号： C07D401/04 , C07D401/14 , C07D405/14 , C07D403/04 , C07D487/08 , C07D487/04
CPC分类号： C07D401/04 , C07D401/14 , C07D405/14 , C07D403/04 , C07D487/08 , C07D487/04
摘要： The disclosure relates to compounds of Formula (I), which are formyl peptide 2 (FPR2) receptor agonists and/or formyl peptide 1 (FPR1) receptor agonists. The disclosure also provides compositions and methods of using the compounds, for example, for the treatment of atherosclerosis, heart failure, chronic obstructive pulmonary disease (COPD), and related diseases. (I)
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公开(公告)号：US20170137427A1
公开(公告)日：2017-05-18
申请号：US15319028
申请日：2015-06-18
发明人： Upender Velaparthi , Selvakumar Kumaravel , Arul Mozhi Selvan Subbiah Karupplah , Shilpa Holehatti Maheshwarappa , Chandrasekhar Reddy Rachamreddy , Mark D. Wittman
IPC分类号： C07D487/04 , C07D519/00
CPC分类号： A61K31/5025 , C07D487/04 , C07D519/00
摘要： The invention provides compounds of Formula (I) and pharmaceutically-acceptable salts thereof. The compounds of Formula (I) inhibit protein kinase activity thereby making them useful as anticancer agents.
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6.发明申请NOVEL SUBSTITUTED PYRAZOLO-PIPERAZINES AS CASEIN KINASE 1 D/E INHIBITORS 有权新型替代吡唑并吡啶作为CASEIN KINASE 1 D / E抑制剂公开(公告)号：US20150133428A1
公开(公告)日：2015-05-14
申请号：US14541343
申请日：2014-11-14
发明人： Upender Velaparthi , Chetan Padmakar Darne , Peiying Liu , Mark D. Wittman , Bradley C. Pearce , Erika M. V. Araujo , Bireshwar Dasgupta , Jalathi Surendran Nair , Sakthi Kumaran Janakiraman , Chandrasekhar Reddy Rachamreddy , Mettu Mallikarjuna Rao , Arul Mozhi Selvan Subbiah Karuppiah , Bandreddy Subba Reddy , Pulicharla Nagalakshmi , Rajesh Onkardas Bora , Shilpa Holehatti Maheshwarappa , Selvakumar Kumaravel , Dibakar Mullick , Ramesh Sistla
IPC分类号： C07D487/04 , C07D487/10 , C07D491/20 , C07D491/147
CPC分类号： C07D487/04 , C07D487/10 , C07D487/20 , C07D491/147 , C07D491/20 , C07D519/00
摘要： The invention provides compounds of Formula (I): and pharmaceutically acceptable salts thereof. The compounds of Formula (I) inhibit protein kinase activity thereby making them useful as anticancer agents.
摘要翻译： 本发明提供式（I）化合物及其药学上可接受的盐。 式（I）的化合物抑制蛋白激酶活性，从而使它们用作抗癌剂。
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公开(公告)号：US09956220B2
公开(公告)日：2018-05-01
申请号：US15319028
申请日：2015-06-18
发明人： Upender Velaparthi , Selvakumar Kumaravel , Arul Mozhi Selvan Subbiah Karupplah , Shilpa Holehatti Maheshwarappa , Chandrasekhar Reddy Rachamreddy , Mark D. Wittman
IPC分类号： A61K31/5025 , C07D487/04 , C07D519/00
CPC分类号： A61K31/5025 , C07D487/04 , C07D519/00
摘要： The invention provides compounds of Formula (I) and pharmaceutically-acceptable salts thereof. The compounds of Formula (I) inhibit protein kinase activity thereby making them useful as anticancer agents.
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![SUBSTITUTED 4,5,6,7-TETRAHYDROPYRAZOLO[1,5-A]PYRAZINE DERIVATIVES AS CASEIN KINASE 1 D/E INHIBITORS](/abs-image/US/2016/10/27/US20160311824A1/abs.jpg.150x150.jpg)
8.发明申请SUBSTITUTED 4,5,6,7-TETRAHYDROPYRAZOLO[1,5-A]PYRAZINE DERIVATIVES AS CASEIN KINASE 1 D/E INHIBITORS 审中-公开取代4,5,6,7-四氢吡唑并[1,5-A]吡啶衍生物作为CASEIN KINASE 1 D / E抑制剂公开(公告)号：US20160311824A1
公开(公告)日：2016-10-27
申请号：US15034217
申请日：2014-11-14
发明人： Upender Velaparthi , Chetan Padmakar Dame , Peiying Liu , Mark D Wittman , Bradley C. Pearce , Erika M.V. Araujo , Bireshwar Dasgupta , Jalathi Surendran Nair , Sakthi Kumaran Janakiraman , Chandrasekhar Reddy Rachamreddy , Mallikarjuna Rao Mettu , Arul Mozhi Selvan Subbiah Karuppiah , Bandreddy Subba Reddy , Pulicharla Nagalakshmi , Rajesh Onkardas Bora , Shilpa Holehatti Maheshwarappa , Selvakumar Kumaravel , Dibakar Mullick , Ramesh Sistla
IPC分类号： C07D487/04 , C07D487/20 , C07D491/147 , C07D491/20 , C07D519/00 , C07D487/10
CPC分类号： C07D487/04 , C07D487/10 , C07D487/20 , C07D491/147 , C07D491/20 , C07D519/00
摘要： The invention provides compounds of Formula (I): and pharmaceutically acceptable salts thereof. The compounds of Formula (I) inhibit protein kinase activity thereby making them useful as anticancer agents.
摘要翻译： 及其药学上可接受的盐。 式（I）的化合物抑制蛋白激酶活性，从而使它们用作抗癌剂。
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公开(公告)号：US20160122358A1
公开(公告)日：2016-05-05
申请号：US14994346
申请日：2016-01-13
发明人： Upender Velaparthi , Chetan Padmakar Darne , Peiying Liu , Mark D. Wittman , Bradley C. Pearce , Erika M. V. Araujo , Bireshwar Dasgupta , Jalathi Surendran Nair , Sakthi Kumaran Janakiraman , Chandrasekhar Reddy Rachamreddy , Mallikarjuna Rao Mettu , Arul Mozhi Subbiah Karuppiah , Subba Reddy Bandreddy , Nagalakshmi Pulicharla , Rajesh Onkardas Bora , Shilpa Maheshwarappa Holehatti , Selvakumar Kumaravel , Dibakar Mullick , Ramesh Kumar Sistla
IPC分类号： C07D487/04 , C07D487/20 , C07D491/20 , C07D487/10 , C07D491/147
CPC分类号： C07D487/04 , C07D487/10 , C07D487/20 , C07D491/147 , C07D491/20 , C07D519/00
摘要： The invention provides compounds of Formula (I): and pharmaceutically acceptable salts thereof. The compounds of Formula (I) inhibit protein kinase activity thereby making them useful as anticancer agents.
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10.发明授权公开(公告)号：US09273058B2
公开(公告)日：2016-03-01
申请号：US14541343
申请日：2014-11-14
发明人： Upender Velaparthi , Chetan Padmakar Darne , Peiying Liu , Mark D. Wittman , Bradley C. Pearce , Erika M. V. Araujo , Bireshwar Dasgupta , Jalathi Surendran Nair , Sakthi Kumaran Janakiraman , Chandrasekhar Reddy Rachamreddy , Mettu Mallikarjuna Rao , Arul Mozhi Selvan Subbiah Karuppiah , Bandreddy Subba Reddy , Pulicharla Nagalakshmi , Rajesh Onkardas Bora , Shilpa Holehatti Maheshwarappa , Selvakumar Kumaravel , Dibakar Mullick , Ramesh Sistla
IPC分类号： C07D487/04 , C07D487/10 , C07D487/20 , C07D491/147 , C07D491/20 , A61K31/4985 , A61K31/499 , A61K31/501 , A61K31/506 , A61K31/5377 , A61P19/02
CPC分类号： C07D487/04 , C07D487/10 , C07D487/20 , C07D491/147 , C07D491/20 , C07D519/00
摘要： The invention provides compounds of Formula (I): and pharmaceutically acceptable salts thereof. The compounds of Formula (I) inhibit protein kinase activity thereby making them useful as anticancer agents.
摘要翻译： 本发明提供式（I）化合物及其药学上可接受的盐。 式（I）的化合物抑制蛋白激酶活性，从而使它们用作抗癌剂。
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