公开(公告)号：US12060421B2

公开(公告)日：2024-08-13

申请号：US17227642

申请日：2021-04-12

申请人： BRISTOL-MYERS SQUIBB COMPANY

发明人： Mark F. Maurer ,  Tseng-hui Timothy Chen ,  Brigitte Devaux ,  Mohan Srinivasan ,  Susan H. Julien ,  Paul O. Sheppard ,  Daniel F. Ardourel ,  Indrani Chakraborty

IPC分类号： C07K16/28 ,  A61K39/00 ,  A61P35/00

CPC分类号： C07K16/2803 ,  A61P35/00 ,  A61K2039/505 ,  C07K2317/21 ,  C07K2317/31 ,  C07K2317/34 ,  C07K2317/76 ,  C07K2317/92 ,  Y02A50/30

摘要： The present invention provides antibodies, or antigen binding fragments thereof, that bind to human TIGIT (T cell immunoreceptor with Ig and ITIM domains), as well as uses of these antibodies or fragments in therapeutic applications, such as in the treatment of cancer or chronic viral infection. Such method of treatment include combination therapy with inhibitors of other immunomodulatory receptor interactions, such as the PD-1/PD-L1 interaction. The invention further provides polynucleotides encoding the heavy and/or light chain variable region of the antibodies, expression vectors comprising the polynucleotides encoding the heavy and/or light chain variable region of the antibodies, cells comprising the vectors, and methods of making the antibodies or fragments by expressing them from the cells.

公开(公告)号：US20200071412A1

公开(公告)日：2020-03-05

申请号：US16687107

申请日：2019-11-18

申请人： The Rockefeller University ,  BRISTOL-MYERS SQUIBB COMPANY

发明人： Jeffrey V. Ravetch ,  Rony Dahan ,  Bryan C. Barnhart ,  Brigitte Devaux ,  Aaron P. Yamniuk ,  Shannon L. Okada ,  Brenda L. Stevens

IPC分类号： C07K16/28

摘要： Provided herein are agonistic antibodies, or antigen binding portions thereof, that bind to human CD40. Such antibodies optionally comprise Fc regions with enhanced specificity for FcγRIIb. The invention also provides methods of treatment of cancer or chronic infection by administering the antibodies of the invention to a subject in need thereof.

公开(公告)号：US10196452B2

公开(公告)日：2019-02-05

申请号：US15807351

申请日：2017-11-08

申请人： Pfizer Inc. ,  Bristol-Myers Squibb Company

发明人： Jing Min ,  Yanli Wu ,  Rory F. Finn ,  Barrett R. Thiele ,  Wei Liao ,  Ronald P. Gladue ,  Arvind Rajpal ,  Timothy J. Paradis ,  Peter Brams ,  Brigitte Devaux ,  Yi Wu ,  Kristopher Toy ,  Heidi N. Leblanc ,  Haichun Huang

IPC分类号： C07K16/28 ,  A61K39/00

摘要： The present disclosure provides isolated binding molecules that bind to the human OX40R, nucleic acid molecules encoding an amino acid sequence of the binding molecules, vectors comprising the nucleic acid molecules, host cells containing the vectors, methods of making the binding molecules, pharmaceutical compositions containing the binding molecules, and methods of using the binding molecules or compositions.

公开(公告)号：US11008390B2

公开(公告)日：2021-05-18

申请号：US16228095

申请日：2018-12-20

申请人： BRISTOL-MYERS SQUIBB COMPANY

发明人： Mark F. Maurer ,  Tseng-hui Timothy Chen ,  Brigitte Devaux ,  Mohan Srinivasan ,  Susan H. Julien ,  Paul O. Sheppard ,  Daniel F. Ardourel ,  Indrani Chakraborty

IPC分类号： C07K16/28 ,  A61P35/00 ,  A61K39/00

摘要： The present invention provides antibodies, or antigen binding fragments thereof, that bind to human TIGIT (T cell immunoreceptor with Ig and ITIM domains), as well as uses of these antibodies or fragments in therapeutic applications, such as in the treatment of cancer or chronic viral infection. Such method of treatment include combination therapy with inhibitors of other immunomodulatory receptor interactions, such as the PD-1/PD-L1 interaction. The invention further provides polynucleotides encoding the heavy and/or light chain variable region of the antibodies, expression vectors comprising the polynucleotides encoding the heavy and/or light chain variable region of the antibodies, cells comprising the vectors, and methods of making the antibodies or fragments by expressing them from the cells.

公开(公告)号：US20190248911A1

公开(公告)日：2019-08-15

申请号：US16399379

申请日：2019-04-30

申请人： BRISTOL-MYERS SQUIBB COMPANY

发明人： Bryan C. Barnhart ,  Brigitte Devaux ,  Aaron P. Yamniuk ,  Shannon L. Okada ,  Brenda L. Stevens

IPC分类号： C07K16/28 ,  A61P35/04 ,  A61P35/00 ,  A61P35/02 ,  A61P31/12

CPC分类号： C07K16/2878 ,  A61K2039/505 ,  A61P31/12 ,  A61P35/00 ,  A61P35/02 ,  A61P35/04 ,  C07K2317/21 ,  C07K2317/24 ,  C07K2317/34 ,  C07K2317/52 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/72 ,  C07K2317/73 ,  C07K2317/732 ,  C07K2317/734 ,  C07K2317/75 ,  C07K2317/92 ,  C07K2317/94

摘要： Provided herein are agonistic antibodies, or antigen binding portions thereof, that bind to human CD40. Such antibodies optionally comprise Fc regions with enhanced specificity for FcγRIIb. The invention also provides methods of treatment of cancer or chronic infection by administering the antibodies of the invention to a subject in need thereof.

公开(公告)号：US20180298097A1

公开(公告)日：2018-10-18

申请号：US16017489

申请日：2018-06-25

申请人： Bristol-Myers Squibb Company

发明人： Xiao Min Schebye ,  Mark J. Selby ,  Michelle Minhua Han ,  Christine Bee ,  Andy X. Deng ,  Anan Chuntharapai ,  Brigitte Devaux ,  Huiming Li ,  Paul O. Sheppard ,  Alan J. Korman ,  Daniel F,. Ardourel ,  Ekaterina Deyanova ,  Richard Huang ,  Guodong Chen ,  Michelle Kuhne ,  Hong-An Troung

IPC分类号： C07K16/28 ,  C07K16/30 ,  A61K39/00

摘要： Provided herein are antibodies, or antigen-binding portions thereof, that bind to T-cell immunoglobulin and mucin-domain containing-3 (TIM3) protein. Also provided are uses of these antibodies, or antigen-binding portions thereof, in therapeutic applications, such as treatment of cancer. Further provided are cells that produce the antibodies, or antigen-binding portions thereof, polynucleotides encoding the heavy and/or light chain regions of the antibodies, or antigen-binding portions thereof, and vectors comprising the polynucleotides encoding the heavy and/or light chain regions of the antibodies, or antigen-binding portions thereof.

公开(公告)号：US10077306B2

公开(公告)日：2018-09-18

申请号：US15649380

申请日：2017-07-13

申请人： Bristol-Myers Squibb Company

发明人： Xiao Min Schebye ,  Mark J. Selby ,  Michelle Minhua Han ,  Christine Bee ,  Andy X. Deng ,  Anan Chuntharapai ,  Brigitte Devaux ,  Huiming Li ,  Paul O. Sheppard ,  Alan J. Korman ,  Daniel F. Ardourel ,  Ekaterina Deyanova ,  Richard Huang ,  Guodong Chen ,  Michelle Kuhne ,  Hong-An Troung

IPC分类号： C07K16/00 ,  C07K16/28 ,  C07K16/30 ,  A61K39/00

CPC分类号： C07K16/2803 ,  A61K47/6849 ,  A61K2039/505 ,  A61K2039/507 ,  A61P35/00 ,  C07K16/2818 ,  C07K16/2827 ,  C07K16/2878 ,  C07K16/30 ,  C07K16/3046 ,  C07K2317/21 ,  C07K2317/24 ,  C07K2317/31 ,  C07K2317/33 ,  C07K2317/34 ,  C07K2317/41 ,  C07K2317/52 ,  C07K2317/55 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/71 ,  C07K2317/732 ,  C07K2317/734 ,  C07K2317/74 ,  C07K2317/76 ,  C07K2317/92 ,  C07K2317/94 ,  G01N33/57492

摘要： Provided herein are antibodies, or antigen-binding portions thereof, that bind to T-cell immunoglobulin and mucin-domain containing-3 (TIM3) protein. Also provided are uses of these antibodies, or antigen-binding portions thereof, in therapeutic applications, such as treatment of cancer. Further provided are cells that produce the antibodies, or antigen-binding portions thereof, polynucleotides encoding the heavy and/or light chain regions of the antibodies, or antigen-binding portions thereof, and vectors comprising the polynucleotides encoding the heavy and/or light chain regions of the antibodies, or antigen-binding portions thereof.

公开(公告)号：US20150203574A1

公开(公告)日：2015-07-23

申请号：US14473997

申请日：2014-08-29

申请人： Pfizer Inc. ,  BRISTOL-MYERS SQUIBB COMPANY

发明人： Arvind Rajpal ,  Madhav Narasimha Devalaraja ,  Kristopher Toy ,  Lan Yang ,  Haichun Huang ,  Jun Zhang ,  Peter Brams ,  Brigitte Devaux ,  David B. Passmore

IPC分类号： C07K16/24

CPC分类号： C07K16/248 ,  A61K2039/505 ,  C07K2317/21 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/567 ,  C07K2317/92

摘要： Antibodies and antigen-binding portions thereof that bind to human IL-6 are provided. Also provided are nucleic acids encoding such antibodies and antigen binding portions, methods of making such antibodies and antigen binding portions, compositions comprising such antibodies or antigen binding portions, and uses of such antibodies or antigen binding portions.

公开(公告)号：US11952427B2

公开(公告)日：2024-04-09

申请号：US17694890

申请日：2022-03-15

申请人： Bristol-Myers Squibb Company ,  CytomX Therapeutics, Inc.

发明人： Bryan C. Barnhart ,  Brigitte Devaux ,  Aaron P. Yamniuk ,  Shannon L. Okada ,  Brenda L. Stevens ,  James William West

IPC分类号： C07K16/28 ,  C12N15/63

CPC分类号： C07K16/2878 ,  C12N15/63 ,  C07K2317/56

摘要： Provided herein are agonistic antibodies, or antigen binding portions thereof, that bind to human CD40 and comprise improved heavy and light chain variable regions that impart improved yield and reduced aggregation. The invention also provides methods of treatment of cancer or chronic infection by administering the antibodies of the invention to a subject in need thereof.

公开(公告)号：US11474112B2

公开(公告)日：2022-10-18

申请号：US16422256

申请日：2019-05-24

申请人： Pfizer Inc. ,  Bristol-Myers Squibb Company

发明人： Robert Arch ,  Jun Zhang ,  Michelle Mader ,  Tetsuya Ishino ,  Joel Bard ,  William Finlay ,  Orla Cunningham ,  Ciara Reilly ,  Peter Brams ,  Brigitte Devaux ,  Haichun Huang ,  Karla Henning

IPC分类号： G01N33/68 ,  C07K16/28

摘要： The present invention provides antibodies, or antigen-binding fragment thereof, which specifically bind to tumor necrosis factor (TNF)-like ligand 1A(TL1A) The invention further provides a method of obtaining such antibodies and nucleic acids encoding the same. The invention further relates to compositions and therapeutic methods for use of these antibodies for the treatment and/or prevention of TL1A mediated diseases, disorders or conditions.