公开(公告)号：US09297796B2

公开(公告)日：2016-03-29

申请号：US13497852

申请日：2010-09-24

申请人： Bozhi Tian ,  Ping Xie ,  Thomas J. Kempa ,  Charles M. Lieber ,  Itzhaq Cohen-Karni ,  Quan Qing ,  Xiaojie Duan

发明人： Bozhi Tian ,  Ping Xie ,  Thomas J. Kempa ,  Charles M. Lieber ,  Itzhaq Cohen-Karni ,  Quan Qing ,  Xiaojie Duan

IPC分类号： B82Y99/00 ,  H01L29/06 ,  H01L21/20 ,  G01N33/487 ,  B82Y10/00 ,  B82Y15/00 ,  H01L29/04

CPC分类号： G01N27/4146 ,  B82Y10/00 ,  B82Y15/00 ,  G01N33/48728 ,  H01L21/02603 ,  H01L29/045 ,  H01L29/0665 ,  H01L29/0669 ,  H01L51/0048

摘要： Kinked nanowires are used for measuring electrical potentials inside simple cells. An improved intracellular entrance is achieved by modifying the kinked nanowires with phospholipids.

摘要翻译： 扭曲的纳米线用于测量简单电池内的电位。 改进的细胞内入口通过用磷脂修饰扭结的纳米线来实现。

公开(公告)号：US20120267604A1

公开(公告)日：2012-10-25

申请号：US13497852

申请日：2010-09-24

申请人： Bozhi Tian ,  Ping Xie ,  Thomas J. Kempa ,  Charles M. Lieber ,  Itzhaq Cohen-Karni ,  Quan Qing ,  Xiaojie Duan

发明人： Bozhi Tian ,  Ping Xie ,  Thomas J. Kempa ,  Charles M. Lieber ,  Itzhaq Cohen-Karni ,  Quan Qing ,  Xiaojie Duan

IPC分类号： H01L29/06 ,  H01L21/20 ,  B82Y99/00

CPC分类号： G01N27/4146 ,  B82Y10/00 ,  B82Y15/00 ,  G01N33/48728 ,  H01L21/02603 ,  H01L29/045 ,  H01L29/0665 ,  H01L29/0669 ,  H01L51/0048

摘要： Kinked nanowires are used for measuring electrical potentials inside simple cells. An improved intracellular entrance is achieved by modifying the kinked nanowires with phospholipids.

摘要翻译： 扭曲的纳米线用于测量简单电池内的电位。 改进的细胞内入口通过用磷脂修饰扭结的纳米线来实现。

公开(公告)号：US20180280968A1

公开(公告)日：2018-10-04

申请号：US15945717

申请日：2018-04-04

申请人： Quan Qing ,  Yuan Wang ,  Joshua Sadar

发明人： Quan Qing ,  Yuan Wang ,  Joshua Sadar

IPC分类号： B01L3/00 ,  C12Q1/6869 ,  G01N27/327

摘要： The present disclosure provides chips, devices and methods for sequencing a biomolecule. The biomolecule may be DNA, RNA. a protein, or a peptide. The chip comprises a substrate; a first and second fluid chamber; fluid channels connecting the first and second fluid chamber; a first and second electrode disposed on opposing sides of the central fluid channel and having a nanogap therebetween, wherein the width of the nanogap is modulated by confined electrochemical deposition; and a passivation layer disposed on top of the first and second electrodes and the fluid channel.