公开(公告)号：US20240117121A1

公开(公告)日：2024-04-11

申请号：US18489223

申请日：2023-10-18

Applicant: Boston Scientific Scimed Inc.

Inventor： Joseph T. Delaney, JR. ,  Paul V. Grosso ,  John Kummailil ,  Tatyana Dyndikova ,  Carey Rehder

IPC: C08G77/04 ,  C08F283/12

CPC classification number: C08G77/045 ,  C08F283/12 ,  A61L27/52

Abstract: In some aspects, the present disclosure pertains to multi-arm polymers that comprise a core and a plurality of polymer segments having a first end that is covalently attached to the core and (a) a second end comprising a moiety that comprises a reactive end group, wherein the polymer segments comprise one or more hydrophilic aprotic NMP-polymerizable monomers, and wherein the reactive multi-arm polymer comprises nitroxide radicals or (b) a second end comprising a moiety that comprises an alkoxyamine group, wherein the core is a polyol residue, and wherein the polymer segments comprise one or more NMP-polymerizable monomers. In some aspects, the present disclosure pertains to a multifunctional alkoxyamine molecule comprising a core and a plurality of alkoxyamine groups covalently attached to the core, wherein the core is a polyol residue.

公开(公告)号：US20210060183A1

公开(公告)日：2021-03-04

申请号：US16999871

申请日：2020-08-21

Applicant: Boston Scientific Scimed Inc.

Inventor： Joseph T. Delaney, JR. ,  Kolbein K. Kolste ,  Tatyana Dyndikova

IPC: A61K49/04 ,  A61L27/52 ,  A61L27/58 ,  C08J3/24 ,  C08L101/00

Abstract: In some aspects, the present disclosure pertains to a polymer that comprises a plurality of polymer arms, wherein a first portion of the polymer arms comprise a reactive end group and wherein a second portion of the polymer arms comprise a branched end group that comprise a plurality of covalently attached diagnostic and/or therapeutic groups, which may be, for example, radiocontrast groups or radioactive groups. Other aspects pertain to a system that comprises (a) a first composition comprising such a polymer and (b) a second composition comprising a multifunctional compound that comprises reactive functional groups that are reactive with the reactive end group of the multi-arm polymer. Still other aspects pertain to a crosslinked reaction product of (a) such a polymer and (b) a multifunctional compound that comprises functional groups that are reactive with the reactive end group of the multi-arm polymer.

公开(公告)号：US20220204655A1

公开(公告)日：2022-06-30

申请号：US17556408

申请日：2021-12-20

Applicant: Boston Scientific Scimed, Inc.

Inventor： Joseph T. Delaney, JR. ,  Kolbein Kolste ,  Tatyana Dyndikova

IPC: C08B37/08 ,  A61K49/04

Abstract: The present disclosure pertains to iodinated polysaccharide compounds that comprise a polysaccharide backbone that comprises a plurality of carboxyl groups and a plurality of iodinated side groups. The present disclosure also pertains iodinated polysaccharide compounds in which at least a portion of carboxyl groups that are present in a carboxyl-containing polysaccharide chain are functionalized with a plurality of iodinated side groups. Other aspects of the present disclosure pertain to methods of forming iodinated polysaccharide compounds, medical compositions comprising iodinated polysaccharide compounds, medical procedures comprising introducing such medical compositions into or between tissue of a patient, and medical kits that comprise such medical compositions.

公开(公告)号：US20240307588A1

公开(公告)日：2024-09-19

申请号：US18675481

申请日：2024-05-28

Applicant: Boston Scientific Scimed, Inc.

Inventor： Joseph T. Delaney, JR. ,  Mark W. Boden ,  John Murphy ,  Viktoria Molnar ,  Tatyana Dyndikova ,  Allison Zipp ,  Kolbein K Kolste

IPC: A61L27/16 ,  A61L27/18 ,  A61L27/38 ,  A61L27/50

CPC classification number: A61L27/16 ,  A61L27/18 ,  A61L27/3839 ,  A61L27/50

Abstract: Described herein are injectable in vivo crosslinking materials for use as soft tissue filler comprising (a) a reactive multi-arm polymer that comprises a plurality of hydrophilic polymeric arms, at least a portion of the hydrophilic polymeric arms comprising one or more reactive end groups and (b) a multifunctional compound that comprises functional groups that are reactive with the reactive end groups of the reactive multi-arm polymer. Also described herein are systems and methods that are based on such materials.

公开(公告)号：US20240139097A1

公开(公告)日：2024-05-02

申请号：US18405864

申请日：2024-01-05

Applicant: Boston Scientific Scimed, Inc.

Inventor： Joseph T. Delaney, JR. ,  Samuel Raybin ,  John Kummailil ,  Matthew B. Hollyer

IPC: A61K9/00 ,  A61K47/02 ,  A61K47/36

CPC classification number: A61K9/0019 ,  A61K47/02 ,  A61K47/36 ,  A61B5/6871

Abstract: The present disclosure relates to injectable compositions sterile injectable fluid compositions comprising a polysaccharide having a color in the visible spectrum, methods of forming the same, kits containing the same, and methods for performing agent-assisted procedures in a patient using the same.

公开(公告)号：US20240026081A1

公开(公告)日：2024-01-25

申请号：US18475397

申请日：2023-09-27

Applicant: Boston Scientific Scimed Inc.

Inventor： Joseph T. Delaney, JR. ,  Paul V. Grosso ,  John Kummailil ,  Tatyana Dyndikova ,  Carey Rehder

IPC: C08G73/02 ,  C08J3/24

CPC classification number: C08G73/0233 ,  C08J3/24 ,  A61L27/52

Abstract: In some aspects, the present disclosure pertains to a multi-arm polymer comprising a core and a plurality of polyoxazoline segments (or arms) having a first end that is covalently attached to the core and a second end comprising a moiety that comprises a reactive group. In some aspects, systems are provided that comprise a first composition comprising such a multi-arm polymer and a second composition comprising a multifunctional compound that comprises functional groups that are reactive with the reactive groups of the multi-arm polymer. In some aspects, systems are provided that comprise crosslinked reaction products of such a multi-arm polymer and such a multifunctional compound.

公开(公告)号：US20210062004A1

公开(公告)日：2021-03-04

申请号：US16999841

申请日：2020-08-21

Applicant: Boston Scientific Scimed Inc.

Inventor： Joseph T. Delaney, JR. ,  Kolbein K. Kolste ,  Tatyana Dyndikova

IPC: C08L101/00 ,  C08J3/24

Abstract: In some aspects, the present disclosure pertains to a polymer that comprises a plurality of polymeric arms, wherein a first portion of the polymeric arms each comprises a reactive end group and wherein a second portion of the polymeric arms each comprises a radiopaque aromatic moiety comprising a monocyclic or multicyclic aromatic structure having a plurality of radiopaque functional groups and a plurality of hydrophilic functional groups. In some aspects, the present disclosure pertains to systems comprising (a) a first composition comprising such a radiopaque polymer and (b) a second composition comprising a multifunctional compound that comprises reactive functional groups that are reactive with the reactive end group. In some aspects, the present disclosure pertains to crosslinked reaction products of (a) such a radiopaque polymer and (b) a multifunctional compound that comprises reactive functional groups that are reactive with the reactive end group.

公开(公告)号：US20230127824A1

公开(公告)日：2023-04-27

申请号：US17972007

申请日：2022-10-24

Applicant: Boston Scientific Scimed Inc.

Inventor： Joseph T. Delaney, JR. ,  Kolbein Kolste ,  Tatyana Dyndikova ,  Yen-Hao Hsu

IPC: A61K49/04 ,  A61M5/19 ,  A61M5/00

Abstract: In some embodiments, the present disclosure pertains to systems for forming a hydrogel that comprise (a) a first composition that comprises a polyiodinated polyamino compound and (b) a second composition that comprises a reactive multi-arm polymer that comprises a plurality of hydrophilic polymer arms having reactive end groups that are reactive with the amino groups of the polyiodinated polyamino compound. In some embodiments, the present disclosure pertains to medical hydrogels that are formed by reacting a polyiodinated polyamino compound and a reactive multi-arm polymer that comprises a plurality of hydrophilic polymer arms having reactive end groups that are reactive with the amino groups of the polyiodinated polyamino compound. In some embodiments, the present disclosure pertains to methods of making polyiodinated polyamino compounds.

公开(公告)号：US20210061957A1

公开(公告)日：2021-03-04

申请号：US16999822

申请日：2020-08-21

Applicant: Boston Scientific Scimed Inc.

Inventor： Joseph T. Delaney, JR. ,  Paul V. Grosso ,  John Kummailil ,  Tatyana Dyndikova ,  Carey Rehder

IPC: C08G77/04 ,  C08F283/12

Abstract: In some aspects, the present disclosure pertains to multi-arm polymers that comprise a core and a plurality of polymer segments having a first end that is covalently attached to the core and (a) a second end comprising a moiety that comprises a reactive end group, wherein the polymer segments comprise one or more hydrophilic aprotic NMP-polymerizable monomers, and wherein the reactive multi-arm polymer comprises nitroxide radicals or (b) a second end comprising a moiety that comprises an alkoxyamine group, wherein the core is a polyol residue, and wherein the polymer segments comprise one or more NMP-polymerizable monomers. In some aspects, the present disclosure pertains to a multifunctional alkoxyamine molecule comprising a core and a plurality of alkoxyamine groups covalently attached to the core, wherein the core is a polyol residue.