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公开(公告)号：US20210061954A1
公开(公告)日：2021-03-04
申请号：US16999787
申请日：2020-08-21
Applicant: Boston Scientific Scimed Inc.
Inventor： Joseph T. Delaney, Jr. , Paul V. Grosso , John Kummailil , Tatyana Dyndikova , Carey Rehder
Abstract: In some aspects, the present disclosure pertains to a multi-arm polymer comprising a core and a plurality of polyoxazoline segments (or arms) having a first end that is covalently attached to the core and a second end comprising a moiety that comprises a reactive group. In some aspects, systems are provided that comprise a first composition comprising such a multi-arm polymer and a second composition comprising a multifunctional compound that comprises functional groups that are reactive with the reactive groups of the multi-arm polymer. In some aspects, systems are provided that comprise crosslinked reaction products of such a multi-arm polymer and such a multifunctional compound.
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公开(公告)号：US12090509B2
公开(公告)日：2024-09-17
申请号：US18054188
申请日：2022-11-10
Applicant: Boston Scientific Scimed, Inc.
Inventor： Joseph T. Delaney, Jr. , John Kummailil , Paul V. Grosso , Yen-Hao Hsu
CPC classification number: B05D1/18 , B05D1/02 , B05D2202/00
Abstract: Methods of treating a substrate, e.g., forming a coating on the substrate, are described. The method may include applying a solution comprising a multifunctional molecule or a multifunctional-polymer molecule to at least a portion of a surface of the substrate. The surface may comprise a metal or metal alloy and the multifunctional molecule or a multifunctional-polymer molecule may bond to the surface via at least one sulfur group of a plurality of sulfur groups of the multifunctional molecule. The method may include combining the multifunctional molecule with a polymer molecule to form the multifunctional polymer molecule before or after applying the solution. The polymer molecule may bond to an internal carbon group or a terminal sulfur group of the multifunctional molecule.
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公开(公告)号：US11938216B2
公开(公告)日：2024-03-26
申请号：US15655320
申请日：2017-07-20
Applicant: Boston Scientific Scimed, Inc.
Inventor： Joseph T. Delaney, Jr. , Samuel Raybin , John Kummailil , Matthew B. Hollyer
CPC classification number: A61K9/0019 , A61K47/02 , A61K47/36 , A61B5/055 , A61B5/6842 , A61B5/687 , A61B5/6871 , A61B5/6873 , A61B2017/00269 , A61B2017/00898 , A61B2017/00942 , A61B17/3478 , A61B2090/3908 , A61B2090/3933 , A61B2090/3937
Abstract: The present disclosure relates to injectable compositions sterile injectable fluid compositions comprising a polysaccharide having a color in the visible spectrum, methods of forming the same, kits containing the same, and methods for performing agent-assisted procedures in a patient using the same.
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公开(公告)号：US11820868B2
公开(公告)日：2023-11-21
申请号：US16999822
申请日：2020-08-21
Applicant: Boston Scientific Scimed Inc.
Inventor： Joseph T. Delaney, Jr. , Paul V. Grosso , John Kummailil , Tatyana Dyndikova , Carey Rehder
IPC: C08F283/12 , C08G77/04 , A61L27/52 , A61L27/58
CPC classification number: C08G77/045 , C08F283/12 , A61L27/52 , A61L27/58
Abstract: In some aspects, the present disclosure pertains to multi-arm polymers that comprise a core and a plurality of polymer segments having a first end that is covalently attached to the core and (a) a second end comprising a moiety that comprises a reactive end group, wherein the polymer segments comprise one or more hydrophilic aprotic NMP-polymerizable monomers, and wherein the reactive multi-arm polymer comprises nitroxide radicals or (b) a second end comprising a moiety that comprises an alkoxyamine group, wherein the core is a polyol residue, and wherein the polymer segments comprise one or more NMP-polymerizable monomers. In some aspects, the present disclosure pertains to a multifunctional alkoxyamine molecule comprising a core and a plurality of alkoxyamine groups covalently attached to the core, wherein the core is a polyol residue.
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公开(公告)号：US11326022B2
公开(公告)日：2022-05-10
申请号：US16999809
申请日：2020-08-21
Applicant: Boston Scientific Scimed Inc.
Inventor： Joseph T. Delaney, Jr. , Carey Rehder , Tatyana Dyndikova , John Kummailil
Abstract: In some aspects, the present disclosure pertains to multi-arm polymers that comprise a core, a plurality of polymer segments having a first end that is covalently attached to the core and a second end comprising a moiety that comprises a reactive group, wherein the polymer segments comprise one or more free-radical-polymerizable monomers. In some aspects, systems are provided that comprise a first composition comprising such a multi-arm polymer and a second composition comprising a multifunctional compound that comprises functional groups that are reactive with the reactive groups of the multi-arm polymer. In some aspects, systems are provided that comprise crosslinked reaction products of such a multi-arm polymer and such a multifunctional compound.
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Patent Agency Ranking
公开(公告)号：US12178888B2
公开(公告)日：2024-12-31
申请号：US16999871
申请日：2020-08-21
Applicant: Boston Scientific Scimed Inc.
Inventor： Joseph T. Delaney, Jr. , Kolbein K. Kolste , Tatyana Dyndikova
Abstract: In some aspects, the present disclosure pertains to a polymer that comprises a plurality of polymer arms, wherein a first portion of the polymer arms comprise a reactive end group and wherein a second portion of the polymer arms comprise a branched end group that comprise a plurality of covalently attached diagnostic and/or therapeutic groups, which may be, for example, radiocontrast groups or radioactive groups. Other aspects pertain to a system that comprises (a) a first composition comprising such a polymer and (b) a second composition comprising a multifunctional compound that comprises reactive functional groups that are reactive with the reactive end group of the multi-arm polymer. Still other aspects pertain to a crosslinked reaction product of (a) such a polymer and (b) a multifunctional compound that comprises functional groups that are reactive with the reactive end group of the multi-arm polymer.
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公开(公告)号：US12016969B2
公开(公告)日：2024-06-25
申请号：US17165485
申请日：2021-02-02
Applicant: Boston Scientific Scimed, Inc.
Inventor： Joseph T. Delaney, Jr. , Mark W. Boden , John Murphy , Viktoria Molnar , Tatyana Dyndikova , Allison Zipp , Kolbein K Kolste
CPC classification number: A61L27/16 , A61L27/18 , A61L27/3839 , A61L27/50
Abstract: Described herein are injectable in vivo crosslinking materials for use as soft tissue filler comprising (a) a reactive multi-arm polymer that comprises a plurality of hydrophilic polymeric arms, at least a portion of the hydrophilic polymeric arms comprising one or more reactive end groups and (b) a multifunctional compound that comprises functional groups that are reactive with the reactive end groups of the reactive multi-arm polymer. Also described herein are systems and methods that are based on such materials.
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公开(公告)号：US11807720B2
公开(公告)日：2023-11-07
申请号：US16999787
申请日：2020-08-21
Applicant: Boston Scientific Scimed Inc.
Inventor： Joseph T. Delaney, Jr. , Paul V. Grosso , John Kummailil , Tatyana Dyndikova , Carey Rehder
CPC classification number: C08G73/0233 , C08J3/24 , A61L27/52
Abstract: In some aspects, the present disclosure pertains to a multi-arm polymer comprising a core and a plurality of polyoxazoline segments (or arms) having a first end that is covalently attached to the core and a second end comprising a moiety that comprises a reactive group. In some aspects, systems are provided that comprise a first composition comprising such a multi-arm polymer and a second composition comprising a multifunctional compound that comprises functional groups that are reactive with the reactive groups of the multi-arm polymer. In some aspects, systems are provided that comprise crosslinked reaction products of such a multi-arm polymer and such a multifunctional compound.
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公开(公告)号：US20210236690A1
公开(公告)日：2021-08-05
申请号：US17165485
申请日：2021-02-02
Applicant: Boston Scientific Scimed, Inc.
Inventor： Joseph T. Delaney, Jr. , Mark W. Boden , John Murphy , Viktoria Molnar , Tatyana Dyndikova , Allison Zipp , Kolbein K Kolste
Abstract: Described herein are injectable in vivo crosslinking materials for use as soft tissue filler comprising (a) a reactive multi-arm polymer that comprises a plurality of hydrophilic polymeric arms, at least a portion of the hydrophilic polymeric arms comprising one or more reactive end groups and (b) a multifunctional compound that comprises functional groups that are reactive with the reactive end groups of the reactive multi-arm polymer. Also described herein are systems and methods that are based on such materials.
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公开(公告)号：US20210061950A1
公开(公告)日：2021-03-04
申请号：US16999809
申请日：2020-08-21
Applicant: Boston Scientific Scimed Inc.
Inventor： Joseph T. Delaney, Jr. , Carey Rehder , Tatyana Dyndikova , John Kummailil
Abstract: In some aspects, the present disclosure pertains to multi-arm polymers that comprise a core, a plurality of polymer segments having a first end that is covalently attached to the core and a second end comprising a moiety that comprises a reactive group, wherein the polymer segments comprise one or more free-radical-polymerizable monomers. In some aspects, systems are provided that comprise a first composition comprising such a multi-arm polymer and a second composition comprising a multifunctional compound that comprises functional groups that are reactive with the reactive groups of the multi-arm polymer. In some aspects, systems are provided that comprise crosslinked reaction products of such a multi-arm polymer and such a multifunctional compound.
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