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公开(公告)号：US20190154688A1
公开(公告)日：2019-05-23
申请号：US16184018
申请日：2018-11-08
Applicant: Boehringer Ingelheim Vetmedica, Inc.
Inventor： Arun V. Iyer , Joseph Ralph Hermann , Michael B. Roof , Eric Martin Vaughn , Merrill Lynn Schaeffer
IPC: G01N33/569 , G01N33/68 , G01N33/50 , A61K39/12 , C12Q1/70 , C12P21/00 , A61K39/145 , C12N7/00 , C07K14/005
CPC classification number: G01N33/56983 , A61K39/12 , A61K39/145 , A61K2039/5252 , C07K14/005 , C07K2319/21 , C07K2319/50 , C12N7/00 , C12N2710/14021 , C12N2710/14022 , C12N2710/14043 , C12N2710/14051 , C12N2710/14143 , C12N2750/10034 , C12N2750/10051 , C12N2760/16134 , C12N2760/16151 , C12N2760/20022 , C12N2760/20034 , C12N2760/20051 , C12P21/00 , C12Q1/701 , G01N33/5091 , G01N33/6854 , G01N2333/01
Abstract: The present invention belongs to the field of compliance markers and marker vaccines which allow for the differentiation between infected and vaccinated individuals. In particular, it relates to a method of determining whether an individual has received an immunogenic composition comprising a recombinant protein produced by a baculovirus expression system in cultured insect cells.
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公开(公告)号：US10168330B2
公开(公告)日：2019-01-01
申请号：US15061690
申请日：2016-03-04
Applicant: Boehringer Ingelheim Vetmedica, Inc.
Inventor： Arun V. Iyer , Joseph Ralph Hermann , Michael B. Roof , Eric Martin Vaughn , Merrill Lynn Schaeffer
IPC: G01N33/569 , C12N7/00 , C12P21/00 , A61K39/145 , C12Q1/70 , G01N33/68 , C07K14/005 , A61K39/12 , G01N33/50 , A61K39/00
Abstract: The present invention belongs to the field of compliance markers and marker vaccines which allow for the differentiation between infected and vaccinated individuals. In particular, it relates to a method of determining whether an individual has received an immunogenic composition comprising a recombinant protein produced by a baculovirus expression system in cultured insect cells.
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公开(公告)号：US09950061B2
公开(公告)日：2018-04-24
申请号：US14672631
申请日：2015-03-30
Applicant: Boehringer Ingelheim Vetmedica, Inc.
Inventor： Luis Alejandro Hernandez , Arun V. Iyer , Dianna M. Murphy Jordan , Abby Rae Patterson , Michael B. Roof , Eric Martin Vaughn , Joseph Gilbert Victoria
IPC: A61K39/215 , A61K45/06 , C07K14/005 , C07K16/10 , C12N7/00 , A61K39/00
CPC classification number: A61K39/215 , A61K45/06 , A61K2039/5252 , A61K2039/552 , C07K14/005 , C07K16/10 , C07K2317/76 , C12N7/00 , C12N2710/14043 , C12N2710/14143 , C12N2770/20021 , C12N2770/20022 , C12N2770/20034 , C12N2770/20063
Abstract: The present invention relates to a vaccine for protecting a pig against diseases associated with porcine epidemic diarrhea virus. The vaccine commonly includes inactivated/killed PEDV (e.g., chemically inactivated PED virus), and/or recombinant PEDV antigen and an adjuvant. Methods for protecting pigs against diseases associated with PEDV and methods of producing the porcine epidemic diarrhea virus vaccine are also provided.
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公开(公告)号：US20180236057A1
公开(公告)日：2018-08-23
申请号：US15957663
申请日：2018-04-19
Applicant: Boehringer Ingelheim Vetmedica, Inc.
Inventor： Michael B. Roof , Phillip Wayne Hayes , Marc Allan Eichmeyer , Gregory Paul Nitzel , Merrill Lynn Schaeffer
Abstract: The present invention relates to the use of an immunogenic composition that comprises a porcine circovirus type 2 (PCV2) antigen for treatment of several clinical manifestations (diseases). Preferably, the clinical manifestations are associated with a PCV2 infection. Preferably, they include lymphadenopathy, lymphoid depletion and/or multinucleated/giant histiocytes. Moreover, the clinical symptoms include lymphadenopathy in combination with one or a multiple of the following symptoms in pigs: (1) interstitial pneumonia with interlobular edema, (2) cutaneous pallor or icterus, (3) mottled atrophic livers, (4) gastric ulcers, (5) nephritis and (6) reproductive disorders, e.g. abortion, stillbirths, mummies, etc. Furthermore the clinical symptoms include Pia like lesions, normally known to be associated with Lawsonia intracellularis infections.
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5.发明申请MULTIVALENT PCV2 IMMUNOGENIC COMPOSITIONS AND METHODS OF PRODUCING SUCH COMPOSITIONS 审中-公开多功能PCV2免疫组合物及其制备方法公开(公告)号：US20150297708A1
公开(公告)日：2015-10-22
申请号：US14755972
申请日：2015-06-30
Applicant: Boehringer Ingelheim Vetmedica, Inc.
Inventor： Michael B. Roof , Phillip Wayne Hayes , Marc Allan Eichmeyer , Gregory Paul Nitzel
CPC classification number: A61K39/12 , A61K38/00 , A61K39/04 , A61K49/0004 , A61K2039/545 , A61K2039/552 , A61K2039/55566 , A61K2039/70 , C07K14/005 , C12N2750/10034 , C12N2750/14043 , C12N2770/10034
Abstract: An improved method for recovering the protein expressed by open reading frame 2 from porcine circovirus type 2 is provided. Also provided is recombinant PCV2 ORF2 protein, and immunogenic compositions comprising PCV2 ORF2 protein. Moreover, multivalent combination vaccines are provided which include an immunological agent effective for reducing the incidence of or lessening the severity of PCV2 infection, preferably PCV2 ORF2 protein, or an immunogenic composition comprising PCV2 ORF2 protein, and at least one immunogenic active component of another disease-causing organism in swine.
Abstract translation: 提供了一种用于从猪圆环病毒2型开放阅读框架2回收蛋白质的改进方法。 还提供重组PCV2 ORF2蛋白和包含PCV2 ORF2蛋白的免疫原性组合物。 此外，提供了多价组合疫苗，其包括有效降低PCV2感染的严重性（优选PCV2 ORF2蛋白）或包含PCV2 ORF2蛋白的免疫原性组合物的发生率或降低的免疫学试剂，以及至少一种其它疾病的免疫原性活性成分 在猪中有机体。
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Patent Agency Ranking
公开(公告)号：US09925256B2
公开(公告)日：2018-03-27
申请号：US14755972
申请日：2015-06-30
Applicant: Boehringer Ingelheim Vetmedica, Inc.
Inventor： Michael B. Roof , Phillip Wayne Hayes , Marc Allan Eichmeyer , Gregory Paul Nitzel
CPC classification number: A61K39/12 , A61K38/00 , A61K39/04 , A61K49/0004 , A61K2039/545 , A61K2039/552 , A61K2039/55566 , A61K2039/70 , C07K14/005 , C12N2750/10034 , C12N2750/14043 , C12N2770/10034
Abstract: An improved method for recovering the protein expressed by open reading frame 2 from porcine circovirus type 2 is provided. Also provided is recombinant PCV2 ORF2 protein, and immunogenic compositions comprising PCV2 ORF2 protein. Moreover, multivalent combination vaccines are provided which include an immunological agent effective for reducing the incidence of or lessening the severity of PCV2 infection, preferably PCV2 ORF2 protein, or an immunogenic composition comprising PCV2 ORF2 protein, and at least one immunogenic active component of another disease-causing organism in swine.
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公开(公告)号：US09925255B2
公开(公告)日：2018-03-27
申请号：US14755771
申请日：2015-06-30
Applicant: Boehringer Ingelheim Vetmedica, Inc.
Inventor： Michael B. Roof , Phillip Wayne Hayes , Marc Allan Eichmeyer , Gregory Paul Nitzel
CPC classification number: A61K39/12 , A61K38/00 , A61K39/04 , A61K49/0004 , A61K2039/545 , A61K2039/552 , A61K2039/55566 , A61K2039/70 , C07K14/005 , C12N2750/10034 , C12N2750/14043 , C12N2770/10034
Abstract: An improved method for recovering the protein expressed by open reading frame 2 from porcine circovirus type 2 is provided. Also provided is recombinant PCV2 ORF2 protein, and immunogenic compositions comprising PCV2 ORF2 protein. Moreover, multivalent combination vaccines are provided which include an immunological agent effective for reducing the incidence of or lessening the severity of PCV2 infection, preferably PCV2 ORF2 protein, or an immunogenic composition comprising PCV2 ORF2 protein, and at least one immunogenic active component of another disease-causing organism in swine.
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公开(公告)号：US09833507B2
公开(公告)日：2017-12-05
申请号：US14713700
申请日：2015-05-15
Applicant: Boehringer Ingelheim Vetmedica, Inc.
Inventor： Arun V. Iyer , Dianna M. Murphy Jordan , Abby Rae Patterson , Michael B. Roof , Eric Martin Vaughn , Joseph Gilbert Victoria , Callie Ann Visek
IPC: A61K39/23 , G01N33/68 , C07K14/005 , C12N7/00 , A61K39/00
CPC classification number: A61K39/23 , A61K2039/5252 , A61K2039/5254 , A61K2039/552 , C07K14/005 , C12N7/00 , C12N2750/14021 , C12N2750/14022 , C12N2750/14034 , G01N33/6893
Abstract: The present invention provides novel nucleotides sequences, protein sequences, immunogenic compositions, vaccines, and methods that relate to making and using new porcine parvovirus 5A (PPV5A) that infects, inter alia, domestic swine. The compositions and methods provide for the detection of infections by said new virus, monitoring genetic changes in the viral sequences in wild and domestic animals and herds, and making and using novel vaccines for protecting animals from infection by the virus.
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公开(公告)号：US20170253908A1
公开(公告)日：2017-09-07
申请号：US15456013
申请日：2017-03-10
Applicant: Boehringer Ingelheim Vetmedica, Inc.
Inventor： Marc Allan Eichmeyer , Michael B. Roof , Merrill Lynn Schaeffer , Eric Martin Vaughn , Kun Yang , Jeremy Richard Rush , Daniel John Murfin
IPC: C12Q1/37 , G01N33/569 , C07K7/06 , C07K14/00 , C07K7/08 , G01N33/68 , C07K14/005
Abstract: The invention provides methods and mass-labeled peptides for use in said methods for quantifying the presence of a one or more viral proteins in a sample of a preparation containing agents which bind to said viral protein, using mass-spectroscopic analyses of the sample and standards containing known amounts of labeled and unlabeled signature peptides, in particular wherein said viral proteins are antigens in a vaccine for porcine circovirus.
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公开(公告)号：US20150297707A1
公开(公告)日：2015-10-22
申请号：US14755771
申请日：2015-06-30
Applicant: Boehringer Ingelheim Vetmedica, Inc.
Inventor： Michael B. Roof , Phillip Wayne Hayes , Marc Allan Eichmeyer , Gregory Paul Nitzel
CPC classification number: A61K39/12 , A61K38/00 , A61K39/04 , A61K49/0004 , A61K2039/545 , A61K2039/552 , A61K2039/55566 , A61K2039/70 , C07K14/005 , C12N2750/10034 , C12N2750/14043 , C12N2770/10034
Abstract: An improved method for recovering the protein expressed by open reading frame 2 from porcine circovirus type 2 is provided. Also provided is recombinant PCV2 ORF2 protein, and immunogenic compositions comprising PCV2 ORF2 protein. Moreover, multivalent combination vaccines are provided which include an immunological agent effective for reducing the incidence of or lessening the severity of PCV2 infection, preferably PCV2 ORF2 protein, or an immunogenic composition comprising PCV2 ORF2 protein, and at least one immunogenic active component of another disease-causing organism in swine,
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