公开(公告)号：US10772950B2

公开(公告)日：2020-09-15

申请号：US16015512

申请日：2018-06-22

Applicant: Boehringer Ingelheim Vetmedica, Inc.

Inventor： Marc Allan Eichmeyer ,  Wesley Scott Johnson ,  Eric Martin Vaughn ,  Michelle L. Walz

IPC: A61K39/145 ,  A61K39/00 ,  A61K39/12 ,  C12N7/00 ,  C07K14/005

Abstract: The present invention relates to an immunogenic composition comprising: a) a modified live H3 virus of swine influenza, and b) a modified live H1 virus of swine influenza. Furthermore, the present invention relates to methods for immunizing a subject comprising administering to such subject the immunogenic composition of the present invention. Moreover, the present invention relates to methods of treating or preventing clinical signs caused by swine influenza virus in a subject of need, the method comprising administering to the subject a therapeutically effective amount of an immunogenic composition according to the present invention.

公开(公告)号：US20190154688A1

公开(公告)日：2019-05-23

申请号：US16184018

申请日：2018-11-08

Applicant: Boehringer Ingelheim Vetmedica, Inc.

Inventor： Arun V. Iyer ,  Joseph Ralph Hermann ,  Michael B. Roof ,  Eric Martin Vaughn ,  Merrill Lynn Schaeffer

IPC: G01N33/569 ,  G01N33/68 ,  G01N33/50 ,  A61K39/12 ,  C12Q1/70 ,  C12P21/00 ,  A61K39/145 ,  C12N7/00 ,  C07K14/005

CPC classification number: G01N33/56983 ,  A61K39/12 ,  A61K39/145 ,  A61K2039/5252 ,  C07K14/005 ,  C07K2319/21 ,  C07K2319/50 ,  C12N7/00 ,  C12N2710/14021 ,  C12N2710/14022 ,  C12N2710/14043 ,  C12N2710/14051 ,  C12N2710/14143 ,  C12N2750/10034 ,  C12N2750/10051 ,  C12N2760/16134 ,  C12N2760/16151 ,  C12N2760/20022 ,  C12N2760/20034 ,  C12N2760/20051 ,  C12P21/00 ,  C12Q1/701 ,  G01N33/5091 ,  G01N33/6854 ,  G01N2333/01

Abstract: The present invention belongs to the field of compliance markers and marker vaccines which allow for the differentiation between infected and vaccinated individuals. In particular, it relates to a method of determining whether an individual has received an immunogenic composition comprising a recombinant protein produced by a baculovirus expression system in cultured insect cells.

公开(公告)号：US20190023747A1

公开(公告)日：2019-01-24

申请号：US16154294

申请日：2018-10-08

Applicant: Boehringer Ingelheim Vetmedica, Inc.

Inventor： Luis Alejandro Hernandez ,  Christine Margaret Muehlenthaler ,  Eric Martin Vaughn ,  Gregory Haiwick

IPC: C07K14/005 ,  A61K39/12 ,  C12P21/02 ,  C12N7/00 ,  A61K39/00

Abstract: Vaccination methods to control PCV2 infection with different PCV2 subtypes are disclosed. Specifically, a PCV2 subtype b (PCV2b) ORF2 proteins or immunogenic compositions comprising a PCV2b ORF2 protein are used in a method for the treatment or prevention of an infection with PCV2 of the same PCV2b and/or different subtype; the reduction, prevention or treatment of clinical signs caused by an infection with PCV2 of the same PCV2b or a different subtype; and/or the prevention or treatment of a disease caused by an infection with PCV2 of the same PCV2b and/or a different subtype. The present invention in particular relates to PCV2 subtype b (PCV2b) ORF2 proteins characterized in that they contain at least one mutation in the BC loop that such that the expressed protein is preferably expressed in a higher amount compared to a PCV2 ORF2 protein that does not contain such mutation.

公开(公告)号：US10168330B2

公开(公告)日：2019-01-01

申请号：US15061690

申请日：2016-03-04

Applicant: Boehringer Ingelheim Vetmedica, Inc.

Inventor： Arun V. Iyer ,  Joseph Ralph Hermann ,  Michael B. Roof ,  Eric Martin Vaughn ,  Merrill Lynn Schaeffer

IPC: G01N33/569 ,  C12N7/00 ,  C12P21/00 ,  A61K39/145 ,  C12Q1/70 ,  G01N33/68 ,  C07K14/005 ,  A61K39/12 ,  G01N33/50 ,  A61K39/00

Abstract: The present invention belongs to the field of compliance markers and marker vaccines which allow for the differentiation between infected and vaccinated individuals. In particular, it relates to a method of determining whether an individual has received an immunogenic composition comprising a recombinant protein produced by a baculovirus expression system in cultured insect cells.

公开(公告)号：US09950061B2

公开(公告)日：2018-04-24

申请号：US14672631

申请日：2015-03-30

Applicant: Boehringer Ingelheim Vetmedica, Inc.

Inventor： Luis Alejandro Hernandez ,  Arun V. Iyer ,  Dianna M. Murphy Jordan ,  Abby Rae Patterson ,  Michael B. Roof ,  Eric Martin Vaughn ,  Joseph Gilbert Victoria

IPC: A61K39/215 ,  A61K45/06 ,  C07K14/005 ,  C07K16/10 ,  C12N7/00 ,  A61K39/00

CPC classification number: A61K39/215 ,  A61K45/06 ,  A61K2039/5252 ,  A61K2039/552 ,  C07K14/005 ,  C07K16/10 ,  C07K2317/76 ,  C12N7/00 ,  C12N2710/14043 ,  C12N2710/14143 ,  C12N2770/20021 ,  C12N2770/20022 ,  C12N2770/20034 ,  C12N2770/20063

Abstract: The present invention relates to a vaccine for protecting a pig against diseases associated with porcine epidemic diarrhea virus. The vaccine commonly includes inactivated/killed PEDV (e.g., chemically inactivated PED virus), and/or recombinant PEDV antigen and an adjuvant. Methods for protecting pigs against diseases associated with PEDV and methods of producing the porcine epidemic diarrhea virus vaccine are also provided.

公开(公告)号：US10131696B2

公开(公告)日：2018-11-20

申请号：US15295053

申请日：2016-10-17

Applicant: Boehringer Ingelheim Vetmedica, Inc.

Inventor： Luis Alejandro Hernandez ,  Christine Margaret Muehlenthaler ,  Eric Martin Vaughn ,  Gregory Haiwick

IPC: C07K14/005 ,  A61K39/12 ,  C12P21/02 ,  C12N7/00 ,  A61K39/00

Abstract: Vaccination methods to control PCV2 infection with different PCV2 subtypes are disclosed. Specifically, a PCV2 subtype b (PCV2b) ORF2 proteins or immunogenic compositions comprising a PCV2b ORF2 protein are used in a method for the treatment or prevention of an infection with PCV2 of the same PCV2b and/or different subtype; the reduction, prevention or treatment of clinical signs caused by an infection with PCV2 of the same PCV2b or a different subtype; and/or the prevention or treatment of a disease caused by an infection with PCV2 of the same PCV2b and/or a different subtype. The present invention in particular relates to PCV2 subtype b (PCV2b) ORF2 proteins characterized in that they contain at least one mutation in the BC loop that such that the expressed protein is preferably expressed in a higher amount compared to a PCV2 ORF2 protein that does not contain such mutation.

公开(公告)号：US09827306B2

公开(公告)日：2017-11-28

申请号：US14721490

申请日：2015-05-26

Applicant: Boehringer Ingelheim Vetmedica, Inc.

Inventor： Arun V. Iyer ,  Dianna M. Murphy Jordan ,  Abby Rae Patterson ,  Michael B. Roof ,  Eric Martin Vaughn ,  Joseph Gilbert Victoria ,  Callie Ann Visek

IPC: A61K39/23 ,  C12N7/00 ,  C07K14/005 ,  G01N33/569 ,  A61K39/00

CPC classification number: A61K39/23 ,  A61K2039/53 ,  C07K14/005 ,  C12N7/00 ,  C12N2750/14321 ,  C12N2750/14322 ,  C12N2750/14334 ,  G01N33/56983 ,  G01N2333/015 ,  G01N2469/10

Abstract: The present invention provides novel nucleotides sequences, protein sequences, immunogenic compositions, vaccines, and methods that relate to making and using new porcine parvovirus 5B (PPV5B) that infects, inter alia, domestic swine. The compositions and methods provide for the detection of infections by said new virus, monitoring genetic changes in the viral sequences in wild and domestic animals and herds, and making and using novel vaccines for protecting animals from infection by the virus.

公开(公告)号：US09833507B2

公开(公告)日：2017-12-05

申请号：US14713700

申请日：2015-05-15

Applicant: Boehringer Ingelheim Vetmedica, Inc.

Inventor： Arun V. Iyer ,  Dianna M. Murphy Jordan ,  Abby Rae Patterson ,  Michael B. Roof ,  Eric Martin Vaughn ,  Joseph Gilbert Victoria ,  Callie Ann Visek

IPC: A61K39/23 ,  G01N33/68 ,  C07K14/005 ,  C12N7/00 ,  A61K39/00

CPC classification number: A61K39/23 ,  A61K2039/5252 ,  A61K2039/5254 ,  A61K2039/552 ,  C07K14/005 ,  C12N7/00 ,  C12N2750/14021 ,  C12N2750/14022 ,  C12N2750/14034 ,  G01N33/6893

Abstract: The present invention provides novel nucleotides sequences, protein sequences, immunogenic compositions, vaccines, and methods that relate to making and using new porcine parvovirus 5A (PPV5A) that infects, inter alia, domestic swine. The compositions and methods provide for the detection of infections by said new virus, monitoring genetic changes in the viral sequences in wild and domestic animals and herds, and making and using novel vaccines for protecting animals from infection by the virus.

公开(公告)号：US20170253908A1

公开(公告)日：2017-09-07

申请号：US15456013

申请日：2017-03-10

Applicant: Boehringer Ingelheim Vetmedica, Inc.

Inventor： Marc Allan Eichmeyer ,  Michael B. Roof ,  Merrill Lynn Schaeffer ,  Eric Martin Vaughn ,  Kun Yang ,  Jeremy Richard Rush ,  Daniel John Murfin

IPC: C12Q1/37 ,  G01N33/569 ,  C07K7/06 ,  C07K14/00 ,  C07K7/08 ,  G01N33/68 ,  C07K14/005

Abstract: The invention provides methods and mass-labeled peptides for use in said methods for quantifying the presence of a one or more viral proteins in a sample of a preparation containing agents which bind to said viral protein, using mass-spectroscopic analyses of the sample and standards containing known amounts of labeled and unlabeled signature peptides, in particular wherein said viral proteins are antigens in a vaccine for porcine circovirus.