公开(公告)号：US20210213039A1

公开(公告)日：2021-07-15

申请号：US17218814

申请日：2021-03-31

Applicant: Bitop AG

Inventor： Andreas Bilstein ,  Olaf Scherner ,  Georg Lentzen

IPC: A61K31/7032 ,  A61L26/00 ,  A61K31/505 ,  A61K45/06 ,  C07D239/06 ,  C07H15/04

Abstract: The invention relates to a composition containing as active agent ectoine, hydroxyectoine, glucosylglycerol and/or salts, esters or amides of these compounds for promoting the regeneration of injured body tissue. The invention has special significance for the treatment of chronic wounds or ulcers.

公开(公告)号：US20150104781A1

公开(公告)日：2015-04-16

申请号：US14385391

申请日：2013-03-15

Applicant: bitop AG

Inventor： Andreas Bilstein ,  Georg Lentzen ,  Rene Tolba ,  Fabian Bernal Quesnel

IPC: A01N1/02

CPC classification number: A01N1/0226

Abstract: The invention relates to a storage solution for the preservation of organs, tissue or organ systems to be transplanted, said solution being based on the known HTK, UW or Celsior solutions. In accordance with the invention it has been determined that ischemia and reperfusion injury could be reduced through the addition of ectoine or hydroxyectoine.

Abstract translation: 本发明涉及用于保存要移植的器官，组织或器官系统的储存溶液，所述溶液基于已知的HTK，UW或Celsior溶液。 根据本发明，已经确定可以通过加入ectoine或hydroxyectoine来减少缺血和再灌注损伤。

公开(公告)号：US20160106747A1

公开(公告)日：2016-04-21

申请号：US14980374

申请日：2015-12-28

Applicant: Bitop AG

Inventor： Rene Tolba ,  Gerhild van Echten-Deckert ,  Georg Lentzen ,  Andreas Bilstein

IPC: A61K31/505 ,  A61K9/00 ,  A61K9/08

CPC classification number: A61K31/505 ,  A61K9/0048 ,  A61K9/08

Abstract: A method of treatment of a patient suffering from postoperative inflammatory stress and pain caused by mechanical impact exerted on portions of the body of the patient that causes damaged tissue wherein the inflammatory stress and pain of the operation outlast the healing of damaged tissue and which is not related to, or caused by, uncontrolled proteolysis. The treatment comprises administering a tetrahydropyrimidine selected from ectoine and/or hydroxyectoine to the patient.

Abstract translation: 一种治疗患有术后炎症应激和疼痛的患者的方法，所述患者由造成受损组织的患者体内的部分机械冲击引起，其中所述炎症应激和所述手术的疼痛超过受损组织的愈合，而不是 与不受控制的蛋白水解相关或由其引起。 该治疗包括向患者施用选自ectoine和/或hydroxyectoine的四氢嘧啶。

公开(公告)号：US20170189435A1

公开(公告)日：2017-07-06

申请号：US15469055

申请日：2017-03-24

Applicant: bitop AG

Inventor： Andreas Bilstein ,  Olaf Scherner ,  Georg Lentzen

IPC: A61K31/7032 ,  A61K45/06 ,  A61K31/505

Abstract: The invention relates to a composition containing as active agent ectoine, hydroxyectoine, glucosylglycerol and/or salts, esters or amides of these compounds for promoting the regeneration of injured body tissue. The invention has special significance for the treatment of chronic wounds or ulcers.