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公开(公告)号：US20240053138A1
公开(公告)日：2024-02-15
申请号：US18486815
申请日：2023-10-13
Applicant: Bioaxial SAS
Inventor： Gabriel Y. Sirat
CPC classification number: G01B11/14 , G01N21/6458 , G01N21/6428 , G02B21/0056 , G02B21/0072 , G02B21/0076 , G01N21/64 , G02B21/16 , G01B11/25
Abstract: A method of optical measurement for determining a spatial position of at least one luminous object in a sample includes: projecting onto the sample a dynamically optimized sequence of compact luminous distributions of different topological families; wherein the dynamically optimized sequence is determined based on data selected from the group consisting of a positioning hypothesis and a first set of measures; for each compact luminous distribution in the optimized sequence, generating an image of the at least one luminous object as illuminated thereby; and algorithmically analyzing the generated images to obtain spatial position information of the at least one luminous object.
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公开(公告)号：US20230168199A1
公开(公告)日：2023-06-01
申请号：US18102333
申请日：2023-01-27
Applicant: Bioaxial SAS
Inventor： Gabriel Y. Sirat
CPC classification number: G01N21/6458 , G02B21/365 , G01N2201/066
Abstract: A super resolution technique, intended mainly for fluorescence microscopy, acquires the three-dimensional position of an emitter, through a hybrid method, including a number of steps.
In a first step the two-dimensional position of an emitter is acquired, using a technique, named in this application as an Abbe’s loophole technique., In this technique a doughnut, or a combination of distributions, having a zero intensity at the combined center of the distributions, is projected onto the sample containing the emitter, under conditions wherein the doughnut null is moved towards the emitter to reach a position in which the emitter does not emit light.
In a second step, an axial measurement is obtained using a 3D shaping method, characterized by the fact that the emitted light is shaped by an additional optical module creating a shape of the light emitted by the emitter, this shape being dependent of the axial position and means to retrieve the axial position from the shape.-
公开(公告)号：US10247931B2
公开(公告)日：2019-04-02
申请号：US15649067
申请日：2017-07-13
Applicant: Bioaxial SAS
Inventor： Gabriel Y. Sirat
Abstract: An optical measurement method and an optical measurement device for determining the spatial or spatiotemporal distribution of a sample, the sample comprising at least one retransmission source retransmitting light depending on light projected onto the sample according to a predetermined law. The method has steps of projection onto the sample of at least two compact light distributions belonging to different topological families, which propagate along the same optical path; detection of the light retransmitted by said at least one retransmission source of the sample; generation of at least one optical image from the detected light; and algorithmic analysis of the optical images for obtaining location data on said at least one retransmission source.
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公开(公告)号：US20170336326A1
公开(公告)日：2017-11-23
申请号：US15533725
申请日：2015-12-09
Applicant: Bioaxial SAS
Inventor： Gabriel Y. Sirat , Lionel Moisan , Clément Fallet , Julien Caron , Maxime Dubois
CPC classification number: G01N21/6456 , G01N21/636 , G01N21/6458 , G02B21/00 , G02B21/0056 , G02B21/0072 , G02B21/0076 , G02B21/008
Abstract: An achromatic 3D STED measuring optical process and optical method, based on a conical diffraction effect or an effect of propagation of light in uniaxial crystals, including a cascade of at least two uniaxial or conical diffraction crystals creating, from a laser source, all of the light propagating along substantially the same optical path, from the output of an optical bank to the objective of a microscope. A spatial position of at least one luminous nano-emitter, structured object or a continuous distribution in a sample is determined.Reconstruction of the sample and its spatial and/or temporal and/or spectral properties is treated as an inverse Bayesian problem leading to the definition of an a posteriori distribution, and a posteriori relationship combining, by virtue of the Bayes law, the probabilistic formulation of a noise model, and possible priors on a distribution of light created in the sample by projection.
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公开(公告)号：US20150212308A1
公开(公告)日：2015-07-30
申请号：US14391828
申请日：2013-04-11
Applicant: Bioaxial SAS
Inventor： Gabriel Y. Sirat , Louis Philippe Braitbart
CPC classification number: G02B21/16 , G01N21/6458 , G01N21/6486 , G01N2201/06113 , G01N2201/12 , G02B21/0072 , G02B21/0076 , G02B21/361
Abstract: The invention relates to an optical measurement method and to an optical measurement device for determining the spatial or spatiotemporal distribution of a sample, the sample comprising at least one retransmission source, said at least one retransmission source retransmitting light depending on the projected light, according to a predetermined law, onto the sample, the method comprising: the projection onto the sample of at least two compact light distributions belonging to different topological families, which propagate along the same optical path, the detection of the light retransmitted by said at least one retransmission source of the sample; the generation of at least one optical image from the detected light; and the algorithmic analysis of the optical images for obtaining location data on said at least one retransmission source.
Abstract translation: 本发明涉及一种光学测量方法和一种用于确定样本的空间或时空分布的光学测量装置，所述样本包括至少一个重传源，所述至少一个重发源根据投射光重传光，根据 所述方法包括：将属于不同拓扑族的至少两个紧凑的光分布投射到所述样本上，所述至少两个紧凑的光分布沿着相同的光路传播，所述至少一个重传中重发的光的检测 样品来源; 从检测到的光产生至少一个光学图像; 以及用于在所述至少一个重传源上获得位置数据的光学图像的算法分析。
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Patent Agency Ranking
公开(公告)号：US11236992B2
公开(公告)日：2022-02-01
申请号：US17087238
申请日：2020-11-02
Applicant: Bioaxial SAS
Inventor： Gabriel Y. Sirat
Abstract: An optical method of measurement and an optical apparatus for determining the spatial position of at least one luminous object on a sample. A sequence of at least two compact luminous distributions of different topological families is projected onto the sample, and light re-emitted by the at least one luminous object is detected. At least one optical image is generated for each luminous distribution on the basis of the light detected. The optical images are analyzed to obtain spatiotemporal information regarding the light re-emitted by the at least one luminous object, or location of the at least one luminous object.
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公开(公告)号：US20210190691A1
公开(公告)日：2021-06-24
申请号：US17110018
申请日：2020-12-02
Applicant: Bioaxial SAS
Inventor： Gabriel Y. Sirat
IPC: G01N21/64
Abstract: A super resolution technique, intended mainly for fluorescence microscopy, acquires the three-dimensional position of an emitter, through a hybrid method, including a number of steps.
In a first step the two-dimensional position of an emitter is acquired, using a technique, named in this application as an Abbe's loophole technique. In this technique a doughnut, or a combination of distributions, having a zero intensity at the combined center of the distributions, is projected onto the sample containing the emitter, under conditions wherein the doughnut null is moved towards the emitter to reach a position in which the emitter does not emit light.
In a second step, an axial measurement is obtained using a 3D shaping method, characterized by the fact that the emitted light is shaped by an additional optical module creating a shape of the light emitted by the emitter, this shape being dependent of the axial position and means to retrieve the axial position from the shape.-
公开(公告)号：US20180073862A1
公开(公告)日：2018-03-15
申请号：US15812016
申请日：2017-11-14
Applicant: Bioaxial SAS
Inventor： Gabriel Y. Sirat
CPC classification number: G01B11/14 , G01B11/25 , G01N21/64 , G01N21/6428 , G01N21/6458 , G01N2201/06113 , G01N2201/12 , G02B21/0056 , G02B21/0072 , G02B21/0076 , G02B21/16
Abstract: An optical method of measurement and an optical apparatus for determining the spatial position of at least one luminous object on a sample. A sequence of at least two compact luminous distributions of different topological families is projected onto the sample, and light re-emitted by the luminous object is detected. At least one optical image is generated for each luminous distribution on the basis of the light detected. The optical images are analyzed to obtain spatiotemporal information regarding the light re-emitted by the luminous object, or location of the luminous object.
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公开(公告)号：US20170322406A1
公开(公告)日：2017-11-09
申请号：US15649067
申请日：2017-07-13
Applicant: Bioaxial SAS
Inventor： Gabriel Y. Sirat
CPC classification number: G02B21/16 , G01N21/6458 , G01N21/6486 , G01N2201/06113 , G01N2201/12 , G02B21/0056 , G02B21/0072 , G02B21/0076 , G02B21/361
Abstract: An optical measurement method and an optical measurement device for determining the spatial or spatiotemporal distribution of a sample, the sample comprising at least one retransmission source retransmitting light depending on light projected onto the sample according to a predetermined law. The method has steps of projection onto the sample of at least two compact light distributions belonging to different topological families, which propagate along the same optical path; detection of the light retransmitted by said at least one retransmission source of the sample; generation of at least one optical image from the detected light; and algorithmic analysis of the optical images for obtaining location data on said at least one retransmission source.
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公开(公告)号：US11598630B2
公开(公告)日：2023-03-07
申请号：US17589265
申请日：2022-01-31
Applicant: Bioaxial SAS
Inventor： Gabriel Y. Sirat
Abstract: An optical method of measurement and an optical apparatus for determining the spatial position of at least one luminous object on a sample. A sequence of at least two compact luminous distributions of different topological families is projected onto the sample, and light re-emitted by the at least one luminous object is detected. At least one optical image is generated for each luminous distribution on the basis of the light detected. The optical images are analyzed to obtain spatiotemporal information regarding the light re-emitted by the at least one luminous object, or location of the at least one luminous object.
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