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公开(公告)号：US20150191505A1
公开(公告)日：2015-07-09
申请号：US14598719
申请日：2015-01-16
Applicant: Bio-Rad Laboratories, Inc.
Inventor： Larry J. Cummings , Mark A. Snyder
CPC classification number: C07K1/14 , B01D15/3847 , B01D15/424 , B01J20/048 , B01J20/281 , B01J20/282 , C07K16/00
Abstract: The present invention discloses methods of neutralizing apatite surfaces, for example during chromatography and before protein elution.
Abstract translation: 本发明公开了中和磷灰石表面的方法，例如在色谱法和蛋白质洗脱之前。
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公开(公告)号：US20170312653A1
公开(公告)日：2017-11-02
申请号：US15654275
申请日：2017-07-19
Applicant: Bio-Rad Laboratories, Inc.
Inventor： Larry J. Cummings
CPC classification number: B01D15/203 , B01J20/3475 , B08B3/08
Abstract: The present invention discloses methods of neutralizing apatite surfaces, for example after a flow-through collection of a target and prior to cleaning the chromatography solid support.
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公开(公告)号：US09737829B2
公开(公告)日：2017-08-22
申请号：US15432755
申请日：2017-02-14
Applicant: Bio-Rad Laboratories, Inc.
Inventor： Larry J. Cummings
CPC classification number: B01D15/203 , B01J20/3475 , B08B3/08
Abstract: The present invention discloses methods of neutralizing apatite surfaces, for example after a flow-through collection of a target and prior to cleaning the chromatography solid support.
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公开(公告)号：US09212203B2
公开(公告)日：2015-12-15
申请号：US14598719
申请日：2015-01-16
Applicant: Bio-Rad Laboratories, Inc.
Inventor： Larry J. Cummings , Mark A. Snyder
IPC: C07K1/14 , G01N33/538 , B01D15/38 , B01D15/42 , B01J20/04 , B01J20/281 , B01J20/282 , C07K16/00
CPC classification number: C07K1/14 , B01D15/3847 , B01D15/424 , B01J20/048 , B01J20/281 , B01J20/282 , C07K16/00
Abstract: The present invention discloses methods of neutralizing apatite surfaces, for example during chromatography and before protein elution.
Abstract translation: 本发明公开了中和磷灰石表面的方法，例如在色谱法和蛋白质洗脱之前。
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公开(公告)号：US10676502B2
公开(公告)日：2020-06-09
申请号：US15879239
申请日：2018-01-24
Applicant: Bio-Rad Laboratories, Inc.
Inventor： Larry J. Cummings , Mark A. Snyder
IPC: C07K16/00 , B01J20/04 , B01J20/281 , B01J20/282 , C07K1/14 , B01D15/42 , B01D15/38 , B01D15/34
Abstract: The present invention discloses methods of neutralizing apatite surfaces, for example during chromatography and before protein elution.
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Patent Agency Ranking
公开(公告)号：US10589996B2
公开(公告)日：2020-03-17
申请号：US15725473
申请日：2017-10-05
Applicant: Bio-Rad Laboratories, Inc.
Inventor： Larry J. Cummings , Jie He
IPC: C01B25/32 , B01D15/20 , B01J20/04 , B01J20/34 , C07K1/18 , C01B25/455 , B01J20/282 , C07K1/20 , C07K1/22
Abstract: Methods and compositions are provided for treatment of an apatite-based resin from which retained solutes have been eluted by an elution buffer that contains an alkali metal salt with solutions of calcium ion, phosphate ion, and hydroxide separately from any sample loading and elution buffers. The treatment solutions restore the resin, reversing the deterioration that is caused by the alkali metal salt in the elution buffer.
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公开(公告)号：US20180086638A1
公开(公告)日：2018-03-29
申请号：US15725473
申请日：2017-10-05
Applicant: Bio-Rad Laboratories, Inc.
Inventor： Larry J. Cummings , Jie HE
IPC: C01B25/32 , C01B25/455 , B01D15/20 , B01J20/04 , B01J20/282 , B01J20/34 , C07K1/20 , C07K1/18 , C07K1/22
CPC classification number: C01B25/327 , B01D15/203 , B01J20/048 , B01J20/282 , B01J20/3433 , B01J20/3475 , C01B25/455 , C07K1/18 , C07K1/20 , C07K1/22
Abstract: Methods and compositions are provided for treatment of an apatite-based resin from which retained solutes have been eluted by an elution buffer that contains an alkali metal salt with solutions of calcium ion, phosphate ion, and hydroxide separately from any sample loading and elution buffers. The treatment solutions restore the resin, reversing the deterioration that is caused by the alkali metal salt in the elution buffer.
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公开(公告)号：US09815695B2
公开(公告)日：2017-11-14
申请号：US13891502
申请日：2013-05-10
Applicant: Bio-Rad Laboratories, Inc.
Inventor： Larry J. Cummings , Jie He
IPC: C01B25/32 , C01B25/455 , B01D15/20 , C07K1/18 , B01J20/04 , B01J20/282 , B01J20/34 , C07K1/20 , C07K1/22
CPC classification number: C01B25/327 , B01D15/203 , B01J20/048 , B01J20/282 , B01J20/3433 , B01J20/3475 , C01B25/455 , C07K1/18 , C07K1/20 , C07K1/22
Abstract: Methods and compositions are provided for treatment of an apatite-based resin from which retained solutes have been eluted by an elution buffer that contains an alkali metal salt with solutions of calcium ion, phosphate ion, and hydroxide separately from any sample loading and elution buffers. The treatment solutions restore the resin, reversing the deterioration that is caused by the alkali metal salt in the elution buffer.
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公开(公告)号：US20130323812A1
公开(公告)日：2013-12-05
申请号：US13891502
申请日：2013-05-10
Applicant: BIO-RAD LABORATORIES, INC.
Inventor： Larry J. Cummings , Jie He
IPC: C01B25/32 , C01B25/455
CPC classification number: C01B25/327 , B01D15/203 , B01J20/048 , B01J20/282 , B01J20/3433 , B01J20/3475 , C01B25/455 , C07K1/18 , C07K1/20 , C07K1/22
Abstract: Methods and compositions are provided for treatment of an apatite-based resin from which retained solutes have been eluted by an elution buffer that contains an alkali metal salt with solutions of calcium ion, phosphate ion, and hydroxide separately from any sample loading and elution buffers. The treatment solutions restore the resin, reversing the deterioration that is caused by the alkali metal salt in the elution buffer.
Abstract translation: 提供了用于处理磷灰石基树脂的方法和组合物，其中保留的溶质已经由含有碱金属盐的洗脱缓冲液与钙离子，磷酸根离子和氢氧化物的溶液分离地从任何样品加载和洗脱缓冲液中洗脱出。 处理液还原树脂，逆转洗脱缓冲液中碱金属盐引起的劣化。
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公开(公告)号：US20180155390A1
公开(公告)日：2018-06-07
申请号：US15879239
申请日：2018-01-24
Applicant: Bio-Rad Laboratories, Inc.
Inventor： Larry J. Cummings , Mark A. Snyder
IPC: C07K1/14 , C07K16/00 , B01J20/282 , B01D15/38 , B01J20/04 , B01D15/42 , B01J20/281
CPC classification number: C07K1/14 , B01D15/3847 , B01D15/424 , B01J20/048 , B01J20/281 , B01J20/282 , C07K16/00
Abstract: The present invention discloses methods of neutralizing apatite surfaces, for example during chromatography and before protein elution.
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