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    Detection and signal processing system for particle assays
    2.
    发明授权
    Detection and signal processing system for particle assays 有权

    公开(公告)号：US10060847B2

    公开(公告)日：2018-08-28

    申请号：US15394624

    申请日：2016-12-29

    Applicant: Bio-Rad Laboratories, Inc.

    Inventor： Yunfeng Ling ,  David P. Stumbo ,  George Carman ,  Denis Pristinski

    IPC: G01N15/14

    CPC classification number: G01N15/1429 ,  G01N15/1404 ,  G01N15/1434 ,  G01N15/1459 ,  G01N2015/1461 ,  G01N2015/1488 ,  G01N2021/4707 ,  G01N2021/4728

    Abstract: Systems and methods for detecting and processing signals from particles. In an exemplary method, particles may be passed through a zone of a channel, while the zone is irradiated with light. Interaction of the light with the particles may deflect light and induce photoluminescence. A deflection signal and a photoluminescence signal may be detected from the zone. Particle waveforms may be identified in the deflection signal. At least a subset of the particle waveforms may be double-peak waveforms including a pair of peaks corresponding to a particle entering and exiting the zone. Amplitudes may be obtained from the photoluminescence signal. The amplitudes may correspond to respective particles and their particle waveforms, and at least a subset of the amplitudes may correspond to the double-peak waveforms. Individual particles may be assigned as positive or as negative for an analyte based on the corresponding amplitudes.

    OPTICAL DETECTION SYSTEM FOR PARTICLES
    3.
    发明申请
    OPTICAL DETECTION SYSTEM FOR PARTICLES 有权

    公开(公告)号：US20170191924A1

    公开(公告)日：2017-07-06

    申请号：US15394605

    申请日：2016-12-29

    Applicant: Bio-Rad Laboratories, Inc.

    Inventor： Denis Pristinski

    IPC: G01N15/14 ,  G01N21/64

    CPC classification number: G01N15/1434 ,  G01N15/1404 ,  G01N15/1459 ,  G01N21/6428 ,  G01N2015/1409

    Abstract: Optical detection system and method for particles. In exemplary embodiments, the system may comprise a channel, a light source configured to generate light, and one or more optical elements configured to focus a beam of the light on an irradiation zone within the channel. The system also may comprise a mask operatively disposed in an optical path between the light source and the channel. The mask may be configured to block a portion of the beam, thereby producing a shadow region. The system further may comprise a detector configured to detect light deflected from the beam into the shadow region by interaction with a particle passing through the irradiation zone.

    Optical detection system for particles
    6.
    发明授权
    Optical detection system for particles 有权

    公开(公告)号：US09846111B2

    公开(公告)日：2017-12-19

    申请号：US15394605

    申请日：2016-12-29

    Applicant: Bio-Rad Laboratories, Inc.

    Inventor： Denis Pristinski

    IPC: G01N21/64 ,  G01N15/14

    CPC classification number: G01N15/1434 ,  G01N15/1404 ,  G01N15/1459 ,  G01N21/6428 ,  G01N2015/1409

    Abstract: Optical detection system and method for particles. In exemplary embodiments, the system may comprise a channel, a light source configured to generate light, and one or more optical elements configured to focus a beam of the light on an irradiation zone within the channel. The system also may comprise a mask operatively disposed in an optical path between the light source and the channel. The mask may be configured to block a portion of the beam, thereby producing a shadow region. The system further may comprise a detector configured to detect light deflected from the beam into the shadow region by interaction with a particle passing through the irradiation zone.

    OPTICAL DETECTION SYSTEM WITH LIGHT SAMPLING
    7.
    发明申请
    OPTICAL DETECTION SYSTEM WITH LIGHT SAMPLING 审中-公开

    公开(公告)号：US20170184448A1

    公开(公告)日：2017-06-29

    申请号：US15394515

    申请日：2016-12-29

    Applicant: Bio-Rad Laboratories, Inc.

    Inventor： Denis Pristinski

    IPC: G01J1/04

    CPC classification number: G01J1/0455 ,  G01J1/0407 ,  G01J1/0414 ,  G01J1/0425 ,  G01J1/4257

    Abstract: System, including methods and apparatus, for optical detection. The system may comprise a light source to generate a beam of light, an optical element, and a detector. The optical element may include a light guide having a shaft and a tip, with the tip forming a beveled end of the light guide. The optical element may extend into the beam, such that the tip and at least a portion of the shaft are located inside the beam, and a window of the optical element is located outside the beam. Light of the beam incident on the tip may be transmitted longitudinally through the light guide and out the window, while light of the beam incident on the shaft may be transmitted transversely through the shaft and remains in the beam downstream. The detector may be configured to detect light received from the window.

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