公开(公告)号：US07740089B2

公开(公告)日：2010-06-22

申请号：US10589317

申请日：2005-08-04

申请人： Bernhard Moser ,  Rainer Widmann

发明人： Bernhard Moser ,  Rainer Widmann

IPC分类号： E21B10/58

CPC分类号： E21B10/58 ,  B23B51/02 ,  B23B2226/75 ,  B23B2251/14 ,  B23B2251/50 ,  Y10T408/909

摘要： The invention relates to a drilling tool, especially for percussion drilling, which comprises a cutting element (3) that is configured as a plate (3) or head and that has at least one cutting edge (11) defined by a cutting face (6) and a free face (10). The cutting edge (11) is associated with a first free face section (10a) which is limited in a cutting plane at a right angle to the cutting edge (11) and parallel to the longitudinal axis (L) of the drilling tool (1) by a convex bulge (13) or a convex polygon outline. The vertical height of a rib (14) defined by the first free face section (10a) and an associated first cutting face section (6a) ranges from 0.1 mm to 1.0 mm.

摘要翻译： 本发明涉及一种特别用于冲击钻孔的钻具，其包括构造为板（3）或头部的切割元件（3），并且具有由切割面（6）限定的至少一个切割刃（11） ）和自由面（10）。 刀刃（11）与第一自由面部分（10a）相关联，第一自由面部分（10a）在与切削刃（11）成直角并且平行于钻具（1）的纵向轴线（L）的切割平面中被限制 ）通过凸凸起（13）或凸多边形轮廓。 由第一自由面部分（10a）和相关联的第一切割面部分（6a）限定的肋（14）的垂直高度为0.1mm至1.0mm。

公开(公告)号：US20100061983A1

公开(公告)日：2010-03-11

申请号：US11903330

申请日：2007-09-21

申请人： Marcel Loetscher ,  Bernhard Moser ,  Shixin Qin ,  Charles R. Mackay

发明人： Marcel Loetscher ,  Bernhard Moser ,  Shixin Qin ,  Charles R. Mackay

IPC分类号： A61K39/395 ,  C07H21/02 ,  G01N33/53

CPC分类号： C07K14/7158 ,  A61K38/00 ,  A61K47/642

摘要： The present invention relates to proteins or polypeptides, referred to herein as isolated and/Or recombinant mammalian (e.g., human) IP-10/Mig receptor proteins designated CXC Chemokine Receptor 3 (CXCR3) and variants thereof, including those characterized by selective binding of one or more chemokines (e.g., IP-10 and/or Mig), and/or the ability to induce a cellular response (e.g., chemotaxis, exocytosis). Antibodies reactive with CXCR3 receptors can be produced using the proteins or variants thereof or host cells comprising same as immunogen.

摘要翻译： 本发明涉及称为CXC趋化因子受体3（CXCR3）及其变体的分离和/或重组哺乳动物（例如人）IP-10 / Mig受体蛋白质的蛋白质或多肽，包括特征在于选择性结合 一种或多种趋化因子（例如，IP-10和/或Mig）和/或诱导细胞反应的能力（例如，趋化性，胞吐作用）。 可以使用蛋白质或其变体或包含免疫原的宿主细胞产生与CXCR3受体反应的抗体。

公开(公告)号：US20090130074A1

公开(公告)日：2009-05-21

申请号：US12271576

申请日：2008-11-14

申请人： Bernhard Moser ,  Marlene Brandes Kuchen

发明人： Bernhard Moser ,  Marlene Brandes Kuchen

IPC分类号： A61K35/12 ,  C12N5/08 ,  A61P35/00 ,  A61P31/00

CPC分类号： A61K39/04 ,  A61K35/17 ,  A61K39/0011 ,  A61K2035/124 ,  A61K2039/5154 ,  C12N5/0636 ,  C12N2501/999 ,  C12N2502/11

摘要： Cytotoxic αβ T cells form an essential component in immunity to infections and tumors, and are also implicated in host defense against these challenges. The present disclosure demonstrates the ability of activated γδ T cells to cross-present exogenous antigens to CD8+ αβ T cells, a process previously thought to be mediated best by dendritic cells. In particular, the present disclosure provides a method for cross-presentation of antigen derived from tumor cell or microbial organisms such as viruses, bacteria, yeasts, parasites, and the like, or from cells infected with such organisms, to a CD8+ αβ T cell. Still further, the present disclosure provides a method for treatment of a tumor or a chronic or recurrent infectious disease, comprising delivering an antigen-presenting autologous γδ T cell population above into a patient requiring such treatment. Still yet further, a method is described for preparing a peptide-specific effector T cell.

摘要翻译： 细胞毒性字母表T细胞是免疫感染和肿瘤的重要组成部分，也与宿主防御这些挑战有关。 本公开内容显示了激活的Gammadelta T细胞将外源抗原交叉到CD8 +字母T细胞的能力，这是以前被认为是由树突细胞介导的过程。 特别地，本公开提供了将衍生自肿瘤细胞或微生物生物例如病毒，细菌，酵母，寄生虫等的抗原或从这些生物感染的细胞的抗原交叉呈递到CD8 +字母表T细胞的方法 。 此外，本公开提供了治疗肿瘤或慢性或复发性传染病的方法，包括将上述抗原呈递自体Gammadelta T细胞群输送到需要这种治疗的患者中。 更进一步地，描述了制备肽特异性效应T细胞的方法。

公开(公告)号：US5482124A

公开(公告)日：1996-01-09

申请号：US336649

申请日：1994-11-04

申请人： August Haussmann ,  Bernhard Moser

发明人： August Haussmann ,  Bernhard Moser

IPC分类号： E21B10/44 ,  E21B10/58 ,  E21B10/36

CPC分类号： E21B10/445 ,  E21B10/58

摘要： A rock drill for hammer drilling machines is proposed, which has a helical shank and a drill head which is connected thereto and on whose end face are arranged a main cutting tip inclined in the shape of a roof and also auxiliary cutting tips disposed transversely thereto. The drill head has two laterally opposite flats for the formation of drilling dust grooves. In plan view the drill head has a very largely rectangular shape in cross section, an acute angle .beta..sub.1 being enclosed between the main cutting tip and the trailing auxiliary cutting tips.

摘要翻译： 提出了一种用于锤钻机的凿岩机，其具有连接到其上的螺旋柄和钻头，并且其端面上设置有倾斜为屋顶形状的主切割尖端以及横向设置的辅助切割尖端。 钻头具有两个横向相对的平面，用于形成钻孔灰尘槽。 在俯视图中，钻头的横截面具有非常大的矩形形状，锐角β1被封闭在主切削刀片和后辅助切削刀片之间。

公开(公告)号：US4883135A

公开(公告)日：1989-11-28

申请号：US235936

申请日：1988-08-24

申请人： Bernhard Moser ,  Wolfang Peetz ,  Hermann Hugger

发明人： Bernhard Moser ,  Wolfang Peetz ,  Hermann Hugger

IPC分类号： E21B10/44 ,  E21B10/56 ,  E21B10/58

CPC分类号： E21B10/445 ,  E21B10/56 ,  E21B10/58 ,  Y10T408/9097

摘要： A rock drill for rotary and percussive stressing exhibits equally good or improved transport characteristics of driling dust for a smaller transport groove as compared with prior rock drills. In order to achieve this, a main transport groove having longitudinal profiles is formed, with an interrupted secondary transport groove integrated in the main transport groove, the transport ribs of which exhibit a greater angle of twist than the angle of twist of the main transport groove.

摘要翻译： 用于旋转和冲击应力的凿岩机与以前的凿岩机相比，表现出与较小输送槽相同的良好或改善的输送特性。 为了实现这一点，形成具有纵向轮廓的主输送槽，其中一个中间的二次输送槽整体集成在主输送槽中，其输送肋的扭转角度大于主输送槽的扭转角度 。

公开(公告)号：US08153426B2

公开(公告)日：2012-04-10

申请号：US11573912

申请日：2005-08-11

申请人： Bernhard Moser ,  Marlene Brandes Kuchen

发明人： Bernhard Moser ,  Marlene Brandes Kuchen

IPC分类号： C12N5/071 ,  C12N5/0783 ,  C12N15/00

CPC分类号： C12N5/0636 ,  A61K2039/5154 ,  A61K2039/5158 ,  C12N2501/05 ,  C12N2501/23 ,  C12N2501/999

摘要： The invention relates to a method for the preparation of efficient antigen-presenting human γδ T cells, to the γδ T cells prepared by such a method, and to their use in immunotherapy, vaccination, vaccine development and diagnostics. Similar to dendritic cells (DCs) in potency and efficacy, these human γδ T cells process antigens and present antigenic peptides to αβ T cells and induce antigen-specific responses (proliferation and differentiation) in naïve αβ T cells. γδ T cells are easily purified from peripheral blood, acquire “maturation” status (expression of essential adhesion, co-stimulatory and major histocompatibility complex molecules) within 1 day of in vitro culture under stimulation and induce strong primary and secondary T helper cell and cytotoxic T cell responses. The γδ T cells may be used in a method of treatment of tumors or chronic or recurrent infectious diseases, in identification of novel tumor or pathogen-derived antigens, and in the diagnosis of the immune competence of a patient.

摘要翻译： 本发明涉及一种制备有效的抗原呈递人γδT细胞的方法，涉及通过这种方法制备的γδT细胞，以及它们在免疫治疗，疫苗接种，疫苗开发和诊断中的应用。 这些人γδT细胞与效能和效力方面的树突状细胞（DC）类似，可以处理抗原并将抗原肽存在于α和bgr中。 T细胞，并在初始α和bgr中诱导抗原特异性应答（增殖和分化） T细胞。 γδT细胞从外周血中容易地纯化，在刺激的1天内获得“成熟”状态（必需粘附，共刺激和主要组织相容性复合物分子的表达），并诱导强的初级和辅助性T辅助细胞和细胞毒性 T细胞反应。 γδT细胞可用于治疗肿瘤或慢性或复发性感染性疾病，鉴定新型肿瘤或病原体衍生的抗原以及诊断患者免疫能力的方法。

公开(公告)号：US06260637B1

公开(公告)日：2001-07-17

申请号：US09297890

申请日：1999-05-11

申请人： August Haussmann ,  Mathias Fuss ,  Bernhard Moser ,  Thomas Wagegg

发明人： August Haussmann ,  Mathias Fuss ,  Bernhard Moser ,  Thomas Wagegg

IPC分类号： E21B1058

CPC分类号： E21B10/445

摘要： A rock drill which has a cutting tip of roof-shaped design at its front end is proposed. In order to achieve a reduction in the loading of the carbide cutting tip or an increased drilling capacity in particular in concrete, the flanks are subdivided into flank sections in order to achieve a slimmer embodiment of the drill head.

摘要翻译： 提出了一种在其前端具有屋顶形设计的切割尖端的凿岩机。 为了实现碳化物切削刀片的加载减小或特别是在混凝土中增加的钻孔能力，将侧翼细分为侧面部分，以实现钻头的较细的实施例。

公开(公告)号：US6140064A

公开(公告)日：2000-10-31

申请号：US709838

申请日：1996-09-10

申请人： Marcel Loetscher ,  Bernhard Moser

发明人： Marcel Loetscher ,  Bernhard Moser

IPC分类号： A61K38/00 ,  A61K47/48 ,  C07K14/715 ,  C12N15/12 ,  G01N33/53 ,  C07K14/00 ,  C07K16/00 ,  C12N5/00

CPC分类号： C07K14/7158 ,  A61K47/48269 ,  A61K38/00

摘要： The present invention relates to methods of identifying ligands, and inhibitors (e.g., antagonists) or promoters (e.g., agonists) of receptor function, including methods in which host cells comprising a nucleic acid encoding a CXCR3 or variant thereof are used in an assay to identify and assess the efficacy of ligands, inhibitors or promoters. Inhibitors and promoters of receptor function can be used to modulate receptor activity, permitting selective inhibition of lymphocyte function, particularly of effector cells such as activated T lymphocytes and NK cells for therapeutic purposes.

摘要翻译： 本发明涉及识别受体功能的配体和抑制剂（例如拮抗剂）或启动子（例如激动剂）的方法，包括其中将包含编码CXCR3或其变体的核酸的宿主细胞用于测定中的方法， 鉴定和评估配体，抑制剂或启动子的功效。 受体功能的抑制剂和启动子可用于调节受体活性，允许选择性抑制淋巴细胞功能，特别是效应细胞例如活化的T淋巴细胞和NK细胞用于治疗目的。

公开(公告)号：US6116827A

公开(公告)日：2000-09-12

申请号：US152513

申请日：1998-09-14

申请人： Bernhard Moser ,  Mathias Fuss

发明人： Bernhard Moser ,  Mathias Fuss

IPC分类号： E21B10/36 ,  B23B51/04 ,  B28D1/14 ,  E21B10/26 ,  B23B51/00

CPC分类号： E21B10/26 ,  B23B51/0473 ,  Y10T408/895 ,  Y10T408/8957 ,  Y10T408/906 ,  Y10T408/907

摘要： A drilling tool, in particular for rotary percussion drilling preferably of rock, is proposed, with a drill body preferably equipped with cutting tips toward the drilling side and with an axially arranged bore for receiving an exchangeable center drill. In order to carry out easy mounting and demounting of the center drill, the drilling tool is designed in two parts, the center drill being capable of being introduced into the drilling tool on the clamping side.

摘要翻译： 提出了一种钻孔工具，特别是用于岩石的旋转冲击钻孔，其中钻体优选地配备有朝向钻孔侧的切割尖端以及用于接收可更换的中心钻的轴向布置的孔。 为了实现中心钻的轻松安装和拆卸，钻具分为两部分设计，中心钻可以在夹紧侧被引入到钻具中。

公开(公告)号：US5791424A

公开(公告)日：1998-08-11

申请号：US610404

申请日：1996-03-04

申请人： Bernhard Moser ,  Hans Peter Meyen

发明人： Bernhard Moser ,  Hans Peter Meyen

IPC分类号： E21B10/02 ,  B28D1/04 ,  B28D1/14 ,  E21B7/24 ,  E21B10/04 ,  E21B10/44 ,  E21B10/48

CPC分类号： B28D1/041 ,  E21B10/04 ,  E21B10/445 ,  E21B10/485 ,  E21B7/24

摘要： A drill bit is proposed, in particular for the rotary-percussive drilling of preferably rock, concrete or the like, which includes a thin-walled cylindrical drilling body (106) open to the drilling side and a drill-bit base (20) extending essentially radially and having an axially arranged drill-bit shank (101) for fastening the drill bit. The drill-bit base (20) has an outer contour in the radial direction, which outer contour follows a curve shape which has at least one inflection point. Furthermore, a drill bit is proposed whose drill-bit base (20) has an outer contour which passes through a minimum in the radial direction, the drill-bit base being connected in the rising radially outer curve section of its outer contour to the cylindrical drilling body. Further independent features of the drill bit according to the invention are at least one prominence (19) on the inside of the drill-bit base for crushing the material to be drilled, which prominence (19) projects from the contour of the inside, or a cuttings-discharge flute (109) having a variable helix angle on the outer contour of the drilling body (106).

摘要翻译： 提出了一种钻头，特别是用于优选岩石，混凝土等的旋转冲击式钻孔，其包括向钻孔侧开口的薄壁圆柱形钻体（106）和钻头底座（20），所述钻头底座延伸 基本上径向地具有用于紧固钻头的轴向布置的钻头柄（101）。 钻头基座（20）在径向上具有外轮廓，该外轮廓遵循具有至少一个拐点的曲线形状。 此外，提出了一种钻头，其钻头基座（20）具有沿径向方向通过最小的外轮廓，钻头基座在其外轮廓的上升径向外弯曲部分中连接到圆柱形 钻体。 根据本发明的钻头的其它独立特征是在钻头基座的内侧上的至少一个突出部（19），用于破碎待钻孔的材料，该突起（19）从内部的轮廓突出，或 在所述钻孔体（106）的外轮廓上具有可变螺旋角的切屑排出槽（109）。